Evaluation of topically administered diclofenac liposomal cream for treatment of horses with experimentally induced osteoarthritis

American Journal of Veterinary Research

Volumn 70, Issue 2, 2009, Pages 210-215

  Frisbie, David D ^a   McIlwraith, C Wayne ^a   Kawcak, Chris E ^a   Werpy, Natasha M ^a   Pearce, Gregory L ^b  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b Innovative Data Resources   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DICLOFENAC; EQUI PHAR; LIPOSOME; PHENYLBUTAZONE; PROSTAGLANDIN E2; SURPASS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL LAMENESS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREAM; DRUG EFFICACY; DRUG SYNOVIAL FLUID LEVEL; HISTOPATHOLOGY; HORSE; JOINT RADIOGRAPHY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOARTHRITIS; OSTEOSCLEROSIS; STAINING; SYNOVIAL FLUID;

ADMINISTRATION, TOPICAL; ANIMALS; ARTHROGRAPHY; CARTILAGE, ARTICULAR; DICLOFENAC; HISTOCYTOCHEMISTRY; HORSE DISEASES; HORSES; OSTEOARTHRITIS; PHENYLBUTAZONE; SYNOVIAL FLUID;

ANIMALIA; EQUIDAE;

EID: 60749134793     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.70.2.210     Document Type: Article

References (21)

1. National Animal Health Monitoring System. Part 1: baseline reference of 1998 equine health and management. Fort Collins, Colo: USDA, APHIS, Veterinary Services - Centers for Epidemiology and Animal Health, 1998.
2. National Animal Health Monitoring System. Lameness and laminitis in US horses. Fort Collins, Colo: USDA, APHIS, Veterinary Services - Centers for Epidemiology and Animal Health, 2000.
3. Rossdale PD, Hopes R, Digby NJ, et al. Epidemiological study of wastage among racehorses 1982 and 1983. Vet Rec 1985;116:66-69.
4. Todhunter R, Lust G. Pathophysiology of synovitis: clinical signs and examination in horses. Compend Contin Educ Pract Vet 1990;12:980-992.
5. Carter J, Frisbie D, Carter GK, et al. Managing equine joint inflammation; a roundtable discussion on diagnostic and treatment options. Compend Contin Educ Equine Vet 2007;2(suppl):1-15.
6. Ross MW, Dyson SJ. Diagnosis and management of lameness in the horse. Philadelphia: WB Saunders Co, 2003.
7. McIlwraith CW. Diseases of joints, tendons, ligaments, & related structures. In: Adams OR, Stashak TS, eds. Adams' lameness in horses. 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2002;459-644.
8. Grahame R. Transdermal non-steroidal anti-inflammatory agents. Br J Clin Pract 1995;49:33-35.
9. Mezei M. Biodisposition studies of diclofenac applied topically in liposomal and gel forms on guinea pig skin. Halifax, NS, Canada: College of Pharmacy, Dalhousie University, 1995.
10. Lynn R, Hepler D, Kelch W, et al. Double-blinded placebo-controlled clinical field trial to evaluate the safety and efficacy of topically applied 1% diclofenac liposomal cream for the relief of lameness in horses. Vet Ther 2004;5:128-138.
11. Foland JW, McIlwraith CW, Trotter GW, et al. Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments. Vet Surg 1994;23:369-376.
12. Frisbie DD, Kawcak CE, McIlwraith CW. Evaluation of extra-corporeal shock wave therapy for osteoarthritis, in Proceedings. 50th Annu Conv Am Assoc Equine Pract 2004;261-263.
13. Frisbie DD, Kawcak CE, Baxter GG, et al. Effects of 6α-methylprednisolone acetate on an equine osteochondral fragment exercise model. Am J Vet Res 1998;59:1619-1628.
14. Frisbie DD, Kawcak CE, Trotter GW, et al. Effects of triamcinolone acteonide on an in vivo equine osteochondral fragment exercise model. Equine Vet J 1997;29:349-359.
15. Frisbie DD, Kawcak CE, Werpy NM, et al. Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis. Am J Vet Res 2007;68:290-296.
16. Kawcak CE, Frisbie DD, Trotter GW, et al. Effects of intravenous administration of sodium hyaluronate on carpal joints in exercising horses after arthroscopic surgery and osteochondral fragmentation. Am J Vet Res 1997;58:1132-1140.
17. Frisbie DD, Ghivizzani SC, Robbins PD, et al. Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther 2002;9:12-20.
18. Kester WO. Definition and classification of lameness. In: Practitioners AAEP, ed. Guide for veterinary services and judging veterinary events. 4th ed. Lexington, Ky: Am Assoc Equine Pract, 1991;19.
19. Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 1986;883:173-177.
20. Anderson D, Kollias-Baker C, Colahan P, et al. Urinary and serum concentration of diclofenac after topical application to horses. Vet Ther 2005;6:57-66.
21. Caldwell FJ, Mueller PO, Lynn RC, et al. Effect of topical application of diclofenac liposomal suspension on experimentally induced subcutaneous inflammation in horses. Am J Vet Res 2004;65:271-276.