Urinary and serum concentrations of diclofenac after topical application to horses

Veterinary Therapeutics

Volumn 6, Issue 1, 2005, Pages 57-66

  Anderson, Danielle ^a,d   Kollias Baker, Cynthia ^a   Colahan, Pat ^b   Keene, Robert O ^c   Lynn, Randy C ^c   Hepler, Douglas I ^c  

^a UNIVERSITY OF FLORIDA   (United States)

^b University of Florida College of Veterinary Medicine   (United States)

^c Idexx Pharmaceuticals   (United States)

^d Pharmaceutical Product Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DICLOFENAC; LIPOSOME; SURPASS; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG FORMULATION; DRUG SCREENING; DRUG URINE LEVEL; HORSE; MALE; NONHUMAN; ANIMAL; AREA UNDER THE CURVE; BLOOD; CLINICAL TRIAL; DRUG ADMINISTRATION; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; URINE;

EQUIDAE; EQUUS CABALLUS;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; DICLOFENAC; DRUG ADMINISTRATION SCHEDULE; HORSES; MALE;

EID: 20344408322     PISSN: 15283593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Kallings P: Nonsteroidal anti-inflammatory drugs. Vet Clin North Am Equine Pract 9(3):523-541, 1993.
2. Heyneman CA, Lawless-Liday C, Wall GC: Oral versus topical NSAIDs in rheumatic diseases: A comparison. Drugs 60(3):555-574, 2000.
3. Roth SH, Shainhouse JZ: Efficacy and safety of a topical diclofenac solution (pennsaid) in the treatment of primary osteoarthritis of the knee: A randomized, double-blind, vehicle-controlled clinical trial. Arch Intern Med 164(18):2017-2023, 2004.
4. Scholer DW, Ku EC, Boettcher I, Schweizer A: Pharmacology of diclofenac sodium. Am J Med 80(4B): 34-38, 1986.
5. Brogden RN, Heel RC, Pakes GE, et al: Diclofenac sodium: A review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. Drugs 20(1):24-48, 1980.
6. Todd PA, Sorkin EM: Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 35(3):244-285, 1988.
7. Lynn RC, Hepler DI, Kelch WJ, et al: Double-blinded placebo-controlled clinical field trial to evaluate the safety and efficacy of topically applied 1% diclofenac liposomal cream for the relief of lameness in horses. Vet Ther 5(2):128-138, 2004.
8. Bertone JJ, Lynn RC, Vatistas NJ, et al: Clinical field trial to evaluate the efficacy of topically applied diclofenac liposomal cream for the relief of joint lameness in horses. Proc AAEP 48:190-193, 2002.
9. Grahame R: Transdermal non-steroidal anti-inflammatory agents. Br J Clin Pract 49(1):33-35, 1995.
10. Caldwell FJ, Mueller PO, Lynn RC, Budsberg SC: Effect of topical application of diclofenac liposomal suspension on experimentally induced subcutaneous inflammation in horses. Am J Vet Res 65(3):271-276, 2004.
11. Vemuri S, Rhodes CT: Preparation and characterization of liposomes as therapeutic delivery systems: A review. Pharm Acta Helv 70(2):95-111, 1995.
12. Romsing J, Ostergaard D, Senderovitz T, et al: Pharmacokinetics of oral diclofenac and acetaminophen in children after surgery. Paediatr Anaesth 11(2):205-213, 2001.
13. Gerring EL, Lees P, Taylor JB: Pharmacokinetics of phenylbutazone and its metabolites in the horse. Equine Vet J 13(3):152-157, 1981.
14. Lees P, Landoni MF: Pharmacodynamics and enantioselective pharmacokinetics of racemic carprofen in the horse. J Vet Pharmacol Ther 25(6):433-448, 2002.
15. Dyke TM, Sams RA, Thompson KG, Ashcraft SM: Pharmacokinetics of multiple-dose administration of eltenac in horses. Am J Vet Res 59(11):1447-1450, 1998.
16. United States Equestrian Foundation: 2005 United States Equestrian Foundation, Inc. Rule Book. Available at www.usef.org/content/rules/ruleBook/ 2005; accessed March 22, 2005.
17. United States Equestrian Foundation: Practical Advice Regarding The 2005 Equine Drugs & Medications Rule. Available at www.usef.org/content/ drugsMeds; accessed March 22, 2005.