Efficacy and safety of lamotrigine monotherapy in children and adolescents with epilepsy

European Journal of Paediatric Neurology

Volumn 13, Issue 2, 2009, Pages 141-145

  Valencia, Ignacio ^a   Piñol Ripoll, Gerard ^a   Khurana, Divya S ^a   Hardison, Huntley H ^a   Kothare, Sanjeev V ^a   Melvin, Joseph J ^a   Marks, Harold G ^a   Legido, Agustín ^a  

^a ST CHRISTOPHER'S HOSPITAL FOR CHILDREN   (United States)

Author keywords

Adolescents; Antiepileptic drugs; Children; Epilepsy; Lamotrigine; Monotherapy

Indexed keywords

CARBAMAZEPINE; LAMOTRIGINE; PHENOBARBITAL; PHENYTOIN; TOPIRAMATE; VALPROIC ACID;

ADOLESCENT; ADULT; ARTICLE; BEHAVIOR CHANGE; CHILD; CONTROLLED STUDY; DROWSINESS; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAM; EPILEPSY; FATIGUE; FEMALE; HUMAN; INFANT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NEUTROPENIA; PRESCHOOL CHILD; PRIORITY JOURNAL; RASH; SCHOOL CHILD; SEIZURE; SIDE EFFECT; SOMNOLENCE; STEVENS JOHNSON SYNDROME; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADOLESCENT; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; ELECTROENCEPHALOGRAPHY; EPILEPSIES, PARTIAL; EPILEPSY; EPILEPSY, GENERALIZED; FEMALE; HUMANS; MALE; RETROSPECTIVE STUDIES; SEIZURES; STEVENS-JOHNSON SYNDROME; TREATMENT OUTCOME; TRIAZINES;

EID: 60749100431     PISSN: 10903798     EISSN: 15322130     Source Type: Journal    
DOI: 10.1016/j.ejpn.2008.03.002     Document Type: Article

References (42)

1. Allain H., Schuck S., Nachit-Ouinekh F., Plouin P., Brunon A.M., Boulliat J., et al. Improvement in quality of life after initiation of lamotrigine therapy in patients with epilepsy in a naturalistic treatment setting. Seizure 16 (2007) 173-184
2. Barron T.F., Hunt S.L., Hoban T.F., and Price M.L. Lamotrigine monotherapy in children. Pediatr Neurol 23 (2000) 160-163
3. Baulac M. Rational conversion from antiepileptic polytherapy to monotherapy. Epileptic Disord 5 (2003) 125-132
4. Betts T. Clinical use of lamotrigine. Seizure 1 (1992) 3-6
5. Biraben A., Allain H., Scarabin J.M., Schuck S., and Edan G. Exacerbation of juvenile myoclonic epilepsy with lamotrigine. Neurology 55 (2000) 1758
6. Buchanan N. The efficacy of lamotrigine on seizure control in 34 children, adolescents and young adults with intellectual and physical disability. Seizure 4 (1995) 233-236
7. Camfield P.R., Camfield C.S., Gordon K., and Dooley J.M. If a first antiepileptic drug fails to control a child's epilepsy, what are the chances of success with the next drug?. J Pediatr 131 (1997) 821-824
8. Chmielewska B., Kaminski M.L., and Kawka Z. Long-term monotherapy with lamotrigine in newly diagnosed epilepsy in adults. Ann Univ Mariae Curie Sklodowska [Med] 56 (2001) 43-51
9. Chuang E., Guerreiro M.M., Tsuchie S.Y., Santucci A., Guerreiro C.A., and Montenegro M.A. First, do no harm: the risks of overtreating children with epilepsy. Arq Neuropsiquiatr 65 (2007) 1-4
10. Coppola G., Licciardi F., Sciscio N., Russo F., Carotenuto M., and Pascotto A. Lamotrigine as first-line drug in childhood absence epilepsy: a clinical and neurophysiological study. Brain Dev 26 (2004) 26-29
11. Dooley J., Camfield P., Gordon K., Camfield C., Wirrell Z., and Smith E. Lamotrigine-induced rash in children. Neurology 46 (1996) 240-242
12. Duchowny M., Gilman J., Messenheimer J., Womble G., and Risner M. Long-term tolerability and efficacy of lamotrigine in pediatric patients with epilepsy. J Child Neurol 17 (2002) 278-285
13. Duchowny M., Pellock J.M., Graf W.D., Billard C., Gilman J., Casale E., et al. A placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children. Lamictal pediatric partial seizure study group. Neurology 53 (1999) 1724-1731
14. Engel Jr. J. A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE task force on classification and terminology. Epilepsia 42 (2001) 796-803
15. Frank L.M., Enlow T., Holmes G.L., Manasco P., Concannon S., Chen C., Womble G., and Casale E.J. Lamictal (lamotrigine) monotherapy for typical absence seizures in children. Epilepsia 40 (1990) 973-979
16. French J.A., and Schachter S. A workshop on antiepileptic drug monotherapy indications. Epilepsia 43 Suppl. 10 (2002) 3-27
17. Gamble C.L., Williamson P.R., and Marson A.G. Lamotrigine versus carbamazepine monotherapy for epilepsy. Cochrane Database Syst Rev (2006) CD001031
18. Glauser T.A., Dlugos D.J., Dodson W.E., Grinspan A., Wang S., and Wu S.C. Topiramate monotherapy in newly diagnosed epilepsy in children and adolescents. J Child Neurol 22 (2007) 693-699
19. Goa K.L., Ross S.R., and Chrisp P. Lamotrigine. A review of its pharmacological properties and clinical efficacy in epilepsy. Drugs 46 (1993) 152-176
20. Guberman A.H., Besag F.M., Brodie M.J., Dooley J.M., Duchowny M.S., Pellock J.M., Richens A., et al. Lamotrigine-associated rash: risk/benefit considerations in adults and children. Epilepsia 40 (1999) 985-991
21. Guerrini R., Dravet C., Genton P., Belmonte A., Kaminska A., and Dulac O. Lamotrigine and seizure aggravation in severe myoclonic epilepsy. Epilepsia 39 (1998) 508-512
22. Hahn J.S., Humberg-Roether S., Crowley T., and Low C. Incidence of rash in children treated with lamotrigine (abstract). Epilepsia 38 (1997) S193
23. Hirsch L.J., Weintraub D.B., Buchsbaum R., Spencer H.T., Straka T., Hager M., et al. Predictors of lamotrigine-associated rash. Epilepsia 47 (2006) 318-322
24. Kanner A.M., and Balabanov A.J. The use of monotherapy in patients with epilepsy: an appraisal of the new antiepileptic drugs. Curr Neurol Neurosci Rep 5 (2005) 322-328
25. Karceski S., Morrell M.J., and Carpenter D. Treatment of epilepsy in adults: expert opinion, 2005. Epilepsy Behav 7 Suppl. 1 (2005) S1-S64 [quiz S65-S67]
26. Khurana D.S., Kothare S.V., Valencia I., Melvin J.J., and Legido A. Levetiracetam monotherapy in children with epilepsy. Pediatr Neurol 36 (2007) 227-230
27. Kothare S.V., Kaleyias J., Mostofi N., Valencia I., Melvin J.J., Hobdell E., et al. Efficacy and safety of zonisamide monotherapy in a cohort of children with epilepsy. Pediatr Neurol 34 (2006) 351-354
28. Kothare S.V., Khurana D.S., Mostofi N., Melvin J.J., Marks H.G., Valencia I., et al. Oxcarbazepine monotherapy in children and adolescents: a single-center clinical experience. Pediatr Neurol 35 (2006) 235-239
29. Messenheimer J.A., Giorgi L., and Risner M.E. The tolerability of lamotrigine in children. Drug Saf 22 (2001) 303-312
30. Mikati M.A., and Holmes G.L. Lamotrigine in absence and primary generalized epilepsies. J Child Neurol 12 Suppl. 1 (1997) S29-S37
31. Nieto-Barrera M., Brozmanova M., Capovilla G., Christe W., Pedersen B., Kane K., and O'Neill F. A comparison of monotherapy with lamotrigine or carbamazepine in patients with newly diagnosed partial epilepsy. Epilepsy Res 46 (2001) 145-155
32. Prasad A., Kuzniecky R.I., Knowlton R.C., Welty T.E., Martin R.C., Mendez M., et al. Evolving antiepileptic drug treatment in juvenile myoclonic epilepsy. Arch Neurol 60 (2003) 1100-1105
33. Richens A., and Yuen A.W. Overview of the clinical efficacy of lamotrigine. Epilepsia 32 Suppl. 2 (1991) S13-S16
34. Sander J.W., Hart Y.M., Patsalos P.N., Duncan J.S., and Shorvon S.D. Lamotrigine and generalized seizures (abstract). Epilepsia 32 (1991) S59
35. Schlumberger E., Chavez F., Palacios L., Rey E., Pajot N., and Dulac O. Lamotrigine in treatment of 120 children with epilepsy. Epilepsia 35 (1994) 359-367
36. Shechter T., Shorer Z., Kramer U., Lerman-Sagie T., Ronen E., Rotem R., and Gorodischer R. Adverse reactions of topiramate and lamotrigine in children. Pharmacoepidemiol Drug Saf 14 (2005) 187-192
37. Steinhoff B.J., Ueberall M.A., Siemes H., Kurlemann G., Schmitz B., and Bergmann L. The LAM-SAFE study: lamotrigine versus carbamazepine or valproic acid in newly diagnosed focal and generalised epilepsies in adolescents and adults. Seizure 14 (2005) 597-605
38. Trevathan E., Kerls S.P., Hammer A.E., Vuong A., and Messenheimer J.A. Lamotrigine adjunctive therapy among children and adolescents with primary generalized tonic-clonic seizures. Pediatrics 118 (2006) e371-e378
39. Vazquez B. Monotherapy in epilepsy: role of the newer antiepileptic drugs. Arch Neurol 61 (2004) 1361-1365
40. von Wegerer J., Hesslinger B., Berger M., and Walden J. A calcium antagonistic effect of the new antiepileptic drug lamotrigine. Eur Neuropsychopharmacol 7 (1997) 77-81
41. Wheless J.W., Neto W., and Wang S. Topiramate, carbamazepine, and valproate monotherapy: double-blind comparison in children with newly diagnosed epilepsy. J Child Neurol 19 (2004) 135-141
42. Xie X., Lancaster B., Peakman T., and Garthwaite J. Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones. Pflugers Arch 430 (1995) 437-446