Monotherapy in epilepsy: Role of the newer antiepileptic drugs

Archives of Neurology

Volumn 61, Issue 9, 2004, Pages 1361-1365

  Vazquez, Bianca ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETHOSUXIMIDE; ETIRACETAM; FELBAMATE; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PLACEBO; TIAGABINE; TOPIRAMATE; VALPROIC ACID; VIGABATRIN; ZONISAMIDE;

CLINICAL TRIAL; DATA ANALYSIS; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERABILITY; EPILEPSY; FOCAL EPILEPSY; GRAND MAL EPILEPSY; HUMAN; MEDLINE; META ANALYSIS; MONOTHERAPY; PRIORITY JOURNAL; REVIEW; SEIZURE; SIDE EFFECT; SYSTEMATIC REVIEW;

ANTICONVULSANTS; CARBAMAZEPINE; CLINICAL TRIALS; EPILEPSY; HUMANS; TRIAZINES;

EID: 4444232907     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.61.9.1361     Document Type: Review

References (43)

1. Guberman A. Monotherapy or polytherapy for epilepsy? Can J Neurol Sci. 1998;25:S3-S8.
2. Mattson RH, Cramer JA, Collins JF, et al. Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. N Engl J Med. 1985;313:145-151.
3. Beghi E, Tognoni G. Prognosis of epilepsy in newly referred patients: a multicenter prospective study. Epilepsia. 1988;29:236-243.
4. Schmidt D. Reduction of two-drug therapy in intractable epilepsy. Epilepsia. 1983;24:368-376.
5. Theodore WH, Porter RJ. Removal of sedative-hypnotic antiepileptic drugs from the regimens of patients with intractable epilepsy. Ann Neurol. 1983;13:320-324.
6. Brodie MJ. Monostars: an aid to choosing an antiepileptic drug as monotherapy. Epilepsia. 1999;40(suppl 76):S17-S22.
7. Schneiderman JH. Monotherapy versus polytherapy in epilepsy: a framework for patient management. Can J Neurol Sci. 1998;25:59-513.
8. Collaborative Group for the Study of Epilepsy. Prognosis of epilepsy in newly referred patients: a multicenter prospective study of the effects of monotherapy on the long-term course of epilepsy. Epilepsia. 1992;33:45-51.
9. Heller AJ, Chesterman P, Elwes RDC, et al. Phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed adult epilepsy: a randomised comparative monotherapy trial. J Neurol Neurosurg Psychiatry. 1995;58:44-50.
10. de Silva M, MacArdle B, McGowan M. Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy. Lancet. 1996;347:709-713.
11. Perucca E, Tomson T. Monotherapy trials with the new antiepileptic drugs: study designs, practical relevance and ethical implications. Epilepsy Res. 1999;33:247-262.
12. Theodore WH, Raubertas RF, Porter RJ, et al. Felbamate: a clinical trial for complex partial seizures. Epilepsia. 1991;32:392-397.
13. Faught E, Sachdeo RC, Remler MP, et al. Felbamate monotherapy for partial-onset seizures: an active-control trial. Neurology. 1993;43:688-692.
14. Glauser TA, Nigro M, Sachdeo R, et al; Oxcarbazepine Pediatric Study Group. Adjunctive therapy with oxcarbazepine in children with partial seizures. Neurology. 2000;54:2237-2244.
15. Schachter SC, Vazquez B, Fisher RS, et al. Oxcarbazepine: double-blind, randomized, placebo-control monotherapy trial for partial seizures. Neurology. 1999;52:732-737.
16. Pledger G. Monotherapy trials: presurgical studies. Epilepsy Res. 2001;45:67-71.
17. Kwan P, Brodie MJ. Clinical trials of antiepileptic medications in newly diagnosed patients with epilepsy. Neurology. 2003;60(suppl 4):S2-S12.
18. Beydoun A, Kutluay E. Conversion to monotherapy: clinical trials in patients with refractory partial seizures. Neurology. 2003;60(suppl 4):S13-S25.
19. Chadwick DW, Anhut H, Greiner MJ, et al. A double-blind trial of gabapentin monotherapy for newly diagnosed partial seizures. Neurology. 1998;51:1282-1288.
20. Brodie MJ, Chadwick DW, Anhut H, et al. Gabapentin versus lamotrigine monotherapy: a double-blind comparison in newly diagnosed epilepsy. Epilepsia. 2002;43:993-1000.
21. Brodie MJ, Overstall PW, Giorgi L; The UK Lamotrigine Elderly Study Group. Multicentre, double-blind, randomized comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. Epilepsy Res. 1999;37:81-87.
22. Brodie MJ, Richens A, Yuen AW. Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. Lancet. 1995;345:476-479.
23. Reunanen M, Dam M, Yuen AWC. A randomised open multicenter comparative trial of lamotrigine and carbamazepine as monotherapy in patients with newly diagnosed or recurrent epilepsy. Epilepsy Res. 1996;23:149-155.
24. Dam M, Ekberg R, Loyning Y, Waltimo O, Jakobsen K. A double-blind study comparing oxcarbazepine and carbamazepine in patients with newly diagnosed, previously untreated epilepsy. Epilepsy Res. 1989;3:70-76.
25. Christe W, Kramer G, Vigonius U, et al. A double-blind controlled clinical trial: oxcarbazepine versus sodium valproate in adults with newly diagnosed epilepsy. Epilepsy Res. 1997;26:451-460.
26. Bill PA, Vigonius U, Pohlmann H, et al. A double-blind controlled clinical trial of oxcarbazepine versus phenytoin in adults with previously untreated epilepsy. Epilepsy Res. 1997;27:195-204.
27. Guerreiro MM, Vigonius U, Pohlmann H, et al. A double-blind controlled clinical trial of oxcarbazepine versus phenytoin in children and adolescents with epilepsy. Epilepsy Res. 1997;27:205-213.
28. Kälviäinen R, Äikiä M, Saukkonen AM, Mervaala E, Riekkinen PJ Sr. Vigabatrin vs carbamazepine monotherapy in patients with newly diagnosed epilepsy: a randomized, controlled study. Arch Neurol. 1995;52:989-996.
29. Tanganelli P, Regesta G. Vigabatrin vs carbamazepine monotherapy in newly diagnosed focal epilepsy: a randomized response conditional cross-over study. Epilepsy Res. 1996;25:257-262.
30. Frank LM, Enlow T, Holmes GL, et al. Lamictal monotherapy for typical absence seizures in children. Epilepsia. 1999;40:973-979.
31. Sachdeo R, Kramer LD, Rosenberg A, Sachdeo S. Felbamate monotherapy: controlled trial in patients with partial onset seizures. Ann Neurol. 1992;32:386-392.
32. Gilliam F, Vazquez B, Sackellares JC, et al. An active-control trial of lamotrigine monotherapy for partial seizures. Neurology. 1998;51:1018-1025.
33. Brodie MJ, Yuen AW. Lamotrigine substitution study: evidence for synergism with sodium valproate? Epilepsy Res. 1997;26:423-432.
34. Jozwiak S, Terczynski A. Open study evaluating lamotrigine efficacy and safety in add-on treatment and consecutive monotherapy in patients with carbamazepine- or valproate-resistant epilepsy. Seizure. 2000;9:486-492.
35. Ben-Menachem E, Falter U; The European Levetiracetam Study Group. Efficacy and tolerability of levetiracetam 3000 mg/d in patients with refractory partial seizures: a multicenter, double-blind, responder-selected study evaluating monotherapy. Epilepsia. 2000;41:1276-1283.
36. Beydoun A, Sachdeo RC, Rosenfeld WE, et al. Oxcarbazepine monotherapy for partial-onset seizures, Neurology. 2000;54:2245-2251.
37. Schachter SC. Tiagabine monotherapy in the treatment of partial epilepsy. Epilepsia. 1995;36(suppl6):S2-S6.
38. Sachdeo RC, Reife RA, Lim P, Pledger G. Topiramate monotherapy for partial onset seizures. Epilepsia. 1997;38:294-300.
39. Devinsky O, Faught RE, Wilder BJ, et al. Efficacy of felbamate monotherapy in patients undergoing presurgical evaluation of partial seizures. Epilepsy Res. 1995;20:241-246.
40. Bergey GK, Morris HH, Rosenfeld W, et al. Gabapentin monotherapy: an 8-day, double-blind, dose-controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures. Neurology. 1997;49:739-745.
41. Crawford P. Interactions between antiepileptic drugs and hormonal contraception. CNS Drugs. 2002;16:263-272.
42. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med. 2000;342:314-319.
43. Karceski S, Morrell M, Carpenter D. The expert consensus guideline series: treatment of epilepsy. Epilepsy Behav. 2001;2(suppl 6):A1-A50.