Upregulation of the immunoproteasome in peripheral blood mononuclear cells of patients with IgA nephropathy

Kidney International

Volumn 75, Issue 5, 2009, Pages 536-541

  Coppo, Rosanna ^a   Camilla, Roberta ^a   Alfarano, Alda ^a   Balegno, Sabrina ^a   Mancuso, Domenico ^a   Peruzzi, Licia ^a   Amore, Alessandro ^a   Dal Canton, Antonio ^b   Sepe, Vincenzo ^b   Tovo, Pierangelo ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

IgA nephropathy; Immunoproteasome; NF B; Proteasome; Proteinuria; Transcription factors

Indexed keywords

CHYMOTRYPSIN; CLOPIDOGREL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; TRANSCRIPTION FACTOR RELA; TRYPSIN;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE DYSREGULATION; IMMUNOGLOBULIN A NEPHROPATHY; MAJOR CLINICAL STUDY; MALE; NEPHROTIC SYNDROME; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEINURIA; UPREGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ADOLESCENT; ADULT; ANTIGEN PRESENTATION; BLOOD CELLS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CHYMOTRYPSIN; FEMALE; GLOMERULONEPHRITIS, IGA; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MULTIENZYME COMPLEXES; NF-KAPPA B; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN SUBUNITS; PROTEINURIA; RNA, MESSENGER; UP-REGULATION; YOUNG ADULT;

EID: 60749098431     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.579     Document Type: Article

References (26)

1. Schena FP, Coppo R In: Davidson AM et al. (eds). Oxford Textbook of Clinical Nephrology, 3rd edn. Oxford University Press: Oxford, 2006; 1: 469-501.
2. Coppo R, Amore A. Aberrant glycosylation in IgA nephropathy (IgAN). Kidney Int 2004; 65: 1544-1547.
3. Chintalacharuvu SR, Nagy NU, Sigmund N et al. T cell cytokines determine the severity of experimental IgA nephropathy by regulating IgA glycosylation. Clin Exp Immunol 2001; 126: 326-333.
4. Ciechanover A. Intracellular protein degradation: from a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting (Nobel lecture). Angew Chem Int Ed Engl 2005; 44: 5944-5967.
5. Rock KL, York IA, Saric T et al. Protein degradation and the generation of MHC class I-presented peptides. Adv Immunol 2002; 80: 1-70.
6. Kloetzel PM, Soza A, Stohwasser R. The role of the proteasome system and the proteasome activator PA28 complex in the cellular immune response. Biol Chem 1999; 380: 293-297.
7. Hendil KB, Khan S, Tanaka K. Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes. Biochem J 1998; 332: 749-754.
8. Barton LF, Runnels HA, Schell TD et al. Immune defects in 28-kDa proteasome activator gamma-deficient mice. J Immunol 2004; 172: 3948-3954.
9. Sakai H. Cellular immunoregulatory aspects of IgA nephropathy. Am J Kidney Dis 1988; 12: 430-432.
10. Preston GA, Waga I, Alcorta DA et al. Gene expression profiles of circulating leukocytes correlate with renal disease activity in IgA nephropathy. Kidney Int 2004; 65: 420-430.
11. Macagno A, Kuehn L, de Giuli R et al. Pronounced up-regulation of the PA28alpha/beta proteasome regulator but little increase in the steady-state content of immunoproteasome during dendritic cell maturation. Eur J Immunol 2001; 31: 3271-3280.
12. Krause S, Kuckelkorn U, Dörner T et al. Immunoproteasome subunit LMP2 expression is deregulated in Sjogren's syndrome but not in other autoimmune disorders. Ann Rheum Dis 2006; 65: 1021-1027.
13. Jaitin DA, Schreiber G. Upregulation of a small subset of genes drives type I interferon-induced antiviral memory. J Interferon Cytokine Res 2007; 27: 653-664.
14. Shin EC, Seifert U, Kato T et al. Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection. J Clin Invest 2006; 116: 3006-3014.
15. Aki M, Shimbara N, Takashina M et al. Interferon-gamma induces different subunit organizations and functional diversity of proteasomes. J Biochem 1994; 115: 257-269.
16. Alfarano A, Versace A, Bertolotto G et al. The switch from the standard proteasome to the immuno proteasome in the mononuclear cells of children with vertically acquired HCV infection. Retrovirology 2008; 5(suppl I): P16.
17. Suzuki H, Suzuki Y, Aizawa M et al. Th1 polarization in murine IgA nephropathy directed by bone marrow-derived cells. Kidney Int 2007; 72: 319-327.
18. Yamashita M, Chintalacharuvu SR, Kobayashi N et al. Analysis of innate immune responses in a model of IgA nephropathy induced by Sendai virus. Contrib Nephrol 2007; 157: 159-163.
19. Amore A, Coppo R, Nedrud JG et al. The role of nasal tolerance in a model of IgA nephropathy induced in mice by Sendai virus. Clin Immunol 2004; 113: 101-108.
20. Chintalacharuvu SR, Emancipator SN. The glycosylation of IgA produced by murine B cells is altered by Th2 cytokines. J Immunol 1997; 159: 2327-2333.
21. Hussong SA, Reilly C, Feng X et al. Transformation of the proteasome with age-related macular degeneration. FEBS Lett 2007; 581: 885-890.
22. Descamps-Latscha B, Witko-Sarsat V, Nguyen-Khoa T et al. Early prediction of IgA nephropathy progression: proteinuria and AOPP are strong prognostic markers. Kidney Int 2004; 66: 1606-1612.
23. Coppo R, D'Amico G. Factors predicting progression of IgA nephropathies. J Nephrol 2005; 18: 503-512.
24. Zaza G, Cox S, Sallustio F et al. Specific genomic fingerprints are highly associated to the onset and development of idiopathic IgA nephropathy. Nephrol Dial Transplant 2008; 1: S2, ii5, SO007.
25. Manno C, Strippoli G, D'Altri C et al. A novel simpler histologic classification for renal survival in IgA nephropathy: a retrospective study. AJKD 2007; 49: 763-775.
26. Coppo R, Peruzzi L, Amore A et al. IgACE: a placebo-controlled, randomized trial of angiotensin-converting enzyme inhibitors in children and young people with IgA nephropathy and moderate proteinuria. J Am Soc Nephrol 2007; 18: 1880-1888.