Pronounced up-regulation of the PA28α/β proteasome regulator but little increase in the steady-state content of immunoproteasome during dendritic cell maturation

European Journal of Immunology

Volumn 31, Issue 11, 2001, Pages 3271-3280

  Macagno, Annalisa ^a   Kuehn, Lothar ^a   De Giuli, Rita ^b   Groettrup, Marcus ^a  

^a CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^b LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

Author keywords

Antigen processing; Dendritic cell; MHC class I; PA28; Proteasome

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; PEPTIDE; PROTEASOME;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBUNIT; ENZYME SYNTHESIS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRECIPITATION; PRECURSOR; PRIORITY JOURNAL; PROTEIN ASSEMBLY; REGULATORY MECHANISM; STEADY STATE; T LYMPHOCYTE ACTIVATION;

BINDING SITES; CYSTEINE ENDOPEPTIDASES; DENDRITIC CELLS; HUMANS; INTERFERON TYPE II; MULTIENZYME COMPLEXES; MUSCLE PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BIOSYNTHESIS; PROTEIN SUBUNITS; RNA, MESSENGER; UP-REGULATION;

EID: 0035179929     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200111)31:11<3271::AID-IMMU3271>3.0.CO;2-2     Document Type: Article

References (39)

1. Dendritic cells and the control of immunity
2. Cross-presentation, dendritic cells, tolerance and immunity
3. Structure and functions of the 20 S and 26 S proteasomes
4. Purification of an 11S regulator of the multicatalytic proteinase
5. Identification, purification and characterization of a protein activator (PA28) of the 20S Proteasome (Macropain)
6. Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein
7. MHC class I antigen processing of an Adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells
8. Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1 but not PA28α/β enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope
9. Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28
10. The proteasome regulator PA28α/β can enhance antigen presentation without affecting 20S proteasome subunit composition
11. Dendritic cells upregulate immunoproteasomes and the proteasome regulator PA28 during maturation
12. 20S proteasomes are assembled via distinct precursor complexes. Processing of LMP2 and LMP7 proproteins takes place in 13-16 S preproteasome complexes
13. Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly
14. Identification and characterization of a mammalian protein interacting with 20S proteasome precursors
15. Characterization of the newly identified human Ump1 homologue POMP and analysis of LMP7(Beta 5i) incorporation into 20 S proteasomes
16. Identification of proteassemblin, a mammalian homologue of the yeast protein UMP1p that is required for normal proteasome assembly
17. -/- mice
18. Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells
19. Half-life of proteasomes (multiprotease complexes) in rat liver
20. Interferon-γ induces different subunit organizations and functional diversity of proteasomes
21. Maturation of epidermal Langerhans cells: Increased expression of beta- and gamma-actin isoforms as a basis of specialized cell functions
22. Expression of the actin-bundling protein fascin in cultured human dendritic cells correlates with dendritic morphology and cell differentiation
23. Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes
24. Type I IFNs enhance the terminal differentiation of dendritic cells
25. Differential regulation of human blood dendritic cell subsets by IFNs
26. Final maturation of dendritic cells is associated with impaired responsiveness to IFN-γ and to bacterial IL-12 inducers: Decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells
27. The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome
28. Immunoproteasome assembly: Cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits
29. Human lymphoblast and erythrocyte multicatalytic proteases: Differential peptidase activities and responses to the 11S regulator
30. Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28
31. Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome
32. + T cells
33. Antigen-specific T lymphocytes regulate lipopolysaccharide-induced apoptosis of dendritic cells in vivo
34. CD8+ T cell-dependent elimination of dendritic cells in vivo limits the induction of antitumor immunity
35. The interferon-γ-inducible 11S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20S proteasome in vitro
36. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
37. Human proteasomes analyzed with monoclonal antibodies
38. Proteasome activator PA28 and its interaction with 20S proteasomes
39. T cell receptor (TCR) β chain homodimers on the surface of immature but not mature α, γ, δ chain deficient T cell lines