Study of the mechanism of insulin encapsulation in poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization

Journal of Biomedical Materials Research

Volumn 47, Issue 4, 1997, Pages 568-576

  Aboubakar, Malam ^a   Puisieux, Francis ^a   Couvreur, Patrick ^a   Deyme, Michel ^a   Vauthier, Christine ^a  

^a UNIV PARIS SUD   (France)

Author keywords

Insulin; Isobutylcyanoacrylate; Nanocapsules; Poly(isobutylcyanoacrylate); Polyme rization initiation

Indexed keywords

BIODEGRADATION; BLOOD; ENCAPSULATION; ENZYMES; ETHANOL; GASTROENTEROLOGY; GLUCOSE; MOLECULES; ORGANIC POLYMERS; PATIENT TREATMENT; POLYMERIZATION; POLYPEPTIDES;

DIABETES; GASTROINTESTINAL TRACT; GLYCEMIA; NANOCAPSULES; POLYISOBUTYLCYANOACRYLATE;

INSULIN;

ALCOHOL; BUCRILATE; INSULIN; POLYMER;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENCAPSULATION; INSULIN TREATMENT; POLYMERIZATION;

EID: 0031573490     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4636(19991215)47:4<568::AID-JBM14>3.0.CO;2-X     Document Type: Article

References (17)

1. Chien YW. Human insulin: Basic sciences to therapeutic uses. Drug Dev Indus Pharm 1996;22:753-789.
2. Zhou XH, Li Wan Po A. Peptide and protein drugs. II. Non-parenteral routes of delivery. Int J Pharm 1991;72:117-130.
3. Woodley JF. Enzymatic barriers for GI peptide and protein delivery. Crit Rev Ther Drug Carrier Syst 1994;11:61-95.
4. Walker E, Kissel T, Amidon GL. The intestinal peptide carrier: A potential transport system for small peptide-derived drugs. Adv Drug Deliv Rev 1996;20:33-58.
5. Damgé C, Michel C, Aprahamian M, Couvreur P, Devissaguet JP. Nanocapsules as carriers for oral peptide delivery. J Controlled Release 1990;13:233-239.
6. Damgé C, Michel C, Aprahamian M, Couvreur P. New approaches for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as a drug carrier. Diabetes 1988;37: 246-251.
7. Aprahamian M, Michel C, Humbert W, Devissaguet JP, Damgé C. Transmucosal passage of polyalkylcyanoacrylate nanocapsules as a new drug carrier for small intestine. Biol Cell 1987; 61:69-76.
8. Damgé C, Hillaire-Buys D, Puech R, Hoeltzel A, Michel C, Ribes G. Effect of orally administered insulin nanocapsules in normal and diabetic dogs. Diab Nutr Metab 1995;8:3-9.
9. Al Khouri Fallouh N, Roblot Treupel L, Fessi H, Devissaguet JP, Puisieux F. Development of a new process for manufacture of polyisobutylcyanoacrylate nanocapsules. Int J Pharm 1986; 28:125-132.
10. Leonard F, Kulkarni RK, Brandes G, Nelson J, Cameron J. Synthesis and degradation of poly(alkyl-α-cyanoacrylates). J Appl Polym Sci 1966;10:259-272.
11. Pepper DC. Anionic and zwitterionic polymerization of α cyanoacrylate. J Polym Sci, Polym Symp 1978;62:65-77.
12. Gallardo MM, Roblot Treupel L, Mahuteau J, Genin I, Couvreur P, Plat M, Puisieux F. Nanocapsules et nanosphères d'alkylcyanoacrylates, interactions principe actif-polymère. Proc 5ième Cong Int de Technol Pharmaceutique APGI, Paris, France, Vol. IV; 1989. p 36-47.
13. Guise V, Drouin JY, Benoit J, Mahuteau J, Dumont P, Couvreur P. Vidarabine-loaded nanoparticles: A physico-chemical study. Pharm Res 1996;7:736-746.
14. Damgé C, Vranckx H, Balschmidt P, Couvreur P. Poly(alkylcyanoacrylate) nanospheres for oral administration of insulin. J Pharm Sci 1997;86(12):1403-1409.
15. Baszkin A, Couvreur P, Deyme M, Henry-Michelland S, Albrecht G. Monolayer studies on poly(isobutylcyanoacrylate)-ampicillin association. J Pharm Pharmacol 1987;39:973-977.
16. Gallardo MM, Couarraze G, Denizot D, Treupel L, Couvreur P, Puisieux F. Study of the formation of nanoparticles and nanocapsules of poly(isobutyl-2-cyanoacrylate). Int J Pharm 1993; 100:55-64.
17. Damgé C, Vonderscher J, Marbach P, Pinguet M. Poly(alkylcyanoacrylate) nanocapsules as a delivery system in the rat for octreotide, a long-acting somatostatin analogue. J Pharm Pharmacol 1997;49:949-954.