Effects of the CCR5-Δ32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia

Immunological Investigations

Volumn 38, Issue 1, 2009, Pages 1-13

  Ahlenstiel, Golo ^a   Woitas, Rainer P ^a   Iwan, Agathe ^a   Nattermann, Jacob ^a   Feldmann, Georg ^a   Rockstroh, Jürgen K ^a   Oldenburg, Johannes ^a   Kupfer, Bernd ^a   Sauerbruch, Tilman ^a   Spengler, Ulrich ^a,b  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

CCR5 32; Haemophilia; HCV

Indexed keywords

CHEMOKINE RECEPTOR CCR5; GAMMA INTERFERON; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4; NONSTRUCTURAL PROTEIN 5A; RANTES; VIRUS ANTIGEN; CHEMOKINE; HEPATITIS C ANTIGEN;

ADULT; AGED; ARTICLE; BASE PAIRING; CELL MIGRATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; GENE DELETION; GENE MUTATION; GENOTYPE; HEMOPHILIA; HEPATITIS C; HEPATITIS C VIRUS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS CARRIER; WILD TYPE; CELL MOTION; CELLULAR IMMUNITY; FEMALE; GENETICS; HEMOPHILIA A; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MIDDLE AGED; PATHOGENICITY; PATHOLOGY; SECRETION; VIRULENCE;

ADULT; AGED; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINES; FEMALE; HEMOPHILIA A; HEPACIVIRUS; HEPATITIS C; HEPATITIS C ANTIGENS; HUMANS; IMMUNITY, CELLULAR; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RECEPTORS, CCR5; SEQUENCE DELETION; T-LYMPHOCYTES; VIRULENCE;

EID: 60749093625     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.1080/08820130802307294     Document Type: Article

References (24)

1. Ahlenstiel, G., Berg, T., Woitas, R. P., et al. (2003). Effects of the CCR5-Delta32 mutation on antiviral treatment in chronic hepatitis C. J. Hepatol. 39(2):245-252.
2. Algood, H. M., Flynn, J. L. (2004). CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J. Immunol. 173(5):3287-3296.
3. Apolinario, A., Majano, P. L., Alvarez-Perez, E., et al. (2002). Increased expression of T cell chemokines and their receptors in chronic hepatitis C: relationship with the histological activity of liver disease. Amer. J. Gastroenterol. 97(11):2861-2870.
4. Belnoue, E., Kayibanda, M., Deschemin, J. C., et al. (2003). CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood 101(11):4253-4259.
5. Choo, Q. L., Kuo, G., Weiner, A. J., Overby, L. R., Bradley, D. W., Houghton, M. (1989). Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244(4902):359-362.
6. Cramp, M. E., Carucci, P., Rossol, S., et al. (1999). Hepatitis C virus (HCV) specific immune responses in anti-HCV positive patients without hepatitis C viraemia. Gut 44 (3):424-429.
7. Diepolder, H. M., Zachoval, R., Hoffmann, R. M., et al. (1995). Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346 (8981):1006-1007.
8. Fujihashi, K., McGhee, J. R., Beagley, K. W., et al. (1993). Cytokine-specific ELISPOT assay. Single cell analysis of IL-2, IL-4 and IL-6 producing cells. J. Immunol. Meth. 160 (2):181-189.
9. Glass, W. G., Liu, M. T., Kuziel, W. A., Lane, T. E. (2001). Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus. Virology 288(1):8-17.
10. Hellier, S., Frodsham, A. J., Hennig, B. J., et al. (2003). Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection. Hepatology 38(6):1468-1476.
11. Hoffmann, R. M., Diepolder, H. M., Zachoval, R., et al. (1995). Mapping of immunodominant CD4+ T lymphocyte epitopes of hepatitis C virus antigens and their relevance during the course of chronic infection. Hepatology 21(3):632-638.
12. Huang, Y., Paxton, W. A., Wolinsky, S. M., et al. (1996). The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat. Med. 2(11):1240-1243.
13. Imberti, L., Cariani, E., Bettinardi, A., et al. (1991). An immunoassay for specific amplified HCV sequences. J. Virol Meth. 34(3):233-43.
14. Machado, F. S., Koyama, N. S., Carregaro, V., et al.(2005). CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi. J. Infect. Dis. 191(4):627-636.
15. Mangia, A., Santoro, R., D'Agruma, L., Andriulli, A. (2003). HCV chronic infection and CCR5-delta32/delta32. Gastroenterology 124(3):868-869.
16. Mantovani, A. (1999). The chemokine system: redundancy for robust outputs. Immunol. Today 20(6):254-257.
17. Missale, G., Bertoni, R., Lamonaca, V., et al. (1996). Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the antiviral cell-mediated immune response. J. Clin. Invest. 98(3):706-714.
18. Nansen, A., Christensen, J. P., Andreasen, S. O., Bartholdy, C., Christensen, J. E., Thomsen, A. R. (2002). The role of CC chemokine receptor 5 in antiviral immunity. Blood 99(4):1237-1245.
19. Promrat, K., McDermott, D. H., Gonzalez, C. M., et al. (2003). Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Gastroenterology 124(2):352-360.
20. Samson, M., Libert, F., Doranz, B. J., et al. (1996). Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382(6593):722-725.
21. Wald, O., Pappo, O., Ari, Z. B., et al. (2004). The CCR5Delta32 allele is associated with reduced liver inflammation in hepatitis C virus infection. Eur. J. Immunogenet. 31(6):249-252.
22. Woitas, R. P., Ahlenstiel, G., Iwan, A., et al.(2002). Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C. Gastroenterology 122 (7):1721-1728.
23. Woitas, R. P., Ahlenstiel, G., Sauerbruch, T., Spengler, U. (2003). Reply. Gastroenterology 124(5):1560-1561.
24. Zhang, M., Goedert, J. J., O'Brien, T. R. (2003). High frequency of CCR5-delta32 homozygosity in HCV-infected, HIV-1-uninfected hemophiliacs results from resistance to HIV-1. Gastroenterology 124(3):867-868.