Are patients with schizophrenia insensitive to pain? A reconsideration of the question

Clinical Journal of Pain

Volumn 25, Issue 3, 2009, Pages 244-252

  Bonnot, Olivier ^a   Anderson, George M ^a   Cohen, David ^a   Willer, Jean Claude ^b   Tordjman, Sylvie ^c  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Pain; Pain reactivity; Pain sensitivity; Schizophrenia

Indexed keywords

ANALGESIA (SENSORY DYSFUNCTION); BEHAVIOR; DATA BASE; HUMAN; NEUROPHYSIOLOGY; NOCICEPTION; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; PSYCHOSIS; REVIEW; SCHIZOPHRENIA; SELF REPORT; BIBLIOGRAPHIC DATABASE; FEMALE; MALE; PAIN ASSESSMENT; SOMATOSENSORY DISORDER; STATISTICS;

DATABASES, BIBLIOGRAPHIC; FEMALE; HUMANS; MALE; PAIN MEASUREMENT; SCHIZOPHRENIA; SOMATOSENSORY DISORDERS;

EID: 60649109675     PISSN: 07498047     EISSN: 15365409     Source Type: Journal    
DOI: 10.1097/AJP.0b013e318192be97     Document Type: Review

References (94)

1. IASP. IASP Pain Terminology [IASP Web site]. January 1, 2006. Available at: http://www.iasp-pain.org/terms-p.html. [Accessed December 11, 2006].
2. Tsuang MT, Stone WS, Faraone SV. Genes, environment and schizophrenia. Br J Psychiatry Suppl. 2001;40:s18-s24.
3. Van Os J, Driessen G, Gunther N, et al. Neighbourhood variation in incidence of schizophrenia. Evidence for personenvironment interaction. Br J Psychiatry. 2000;176:243-248.
4. Brewer WJ, Wood SJ, McGorry PD, et al. Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia. Am J Psychiatry. 2003;160:1790-1794.
5. Korn H. Schizophrenic vulnerability: a deficiency of the correlation between foveal perception and oculomotor proprioception? Med Hypotheses. 2000;55:245-252.
6. Moberg PJ, Arnold SE, Doty RL, et al. Impairment of odor hedonics in men with schizophrenia. Am J Psychiatry. 2003; 160:1784-1789.
7. Saoud M, Hueber T, Mandran H, et al. Olfactory identification deficiency and WCST performance in men with schizophrenia. Psychiatry Res. 1998;81:251-257.
8. Kraepelin E. Introduction á la clinique psychiatrique. Paris: Vigot, trad. fr. Devaux A, Merken P; 1907.
9. Kraepelin E. Dementia Praecox and Paraphrenia. Edinburgh, Scotland: VIGOT; 1919.
10. Bleuler E. Textbook of Psychiatry (trans. Brill H.A., 1951). New York: E and S Livingstone; 1911.
11. Bleuler E. Demence pre'coce ou le groupe des schizophre'nies. Paris: Centre d'Etude Psychiatrique, trad. fr. Ey H. (1926); 1964.
12. Singh MK, Giles LL, Nasrallah HA. Pain insensitivity in schizophrenia: trait or state marker? J Psychiatr Pract. 2006; 12:90-102.
13. Rohricht F, Priebe S. Disturbances of body experience in schizophrenic patients. Fortschr Neurol Psychiatr. 1997;65: 323-336.
14. Lautenbacher S, Krieg JC. Pain perception in psychiatric disorders: a review. J Psychiatr Res. 1994;28:109-122.
15. Jakubaschk J, Boker W. Disorders of pain perception in schizophrenia. Schweiz Arch Neurol Psychiatr. 1991;142:55-76.
16. Dworkin RH. Pain insensitivity in schizophrenia: a neglected phenomenon and its applications. Schizophr Bull. 1994;20: 235-248.
17. West BM, Hecker AO. Peptic ulcer; incidence and diagnosis in psychotic patients. Am J Psychiatry. 1952;109:35-37.
18. Lewis C. Diagnostic problems of acute surgical conditions of the abdoment in psychotic patients. Med Bull Vet Admin. 1937; 13:314-320.
19. Geschwind N. Insensitivity to pain in psychotic patients [Letter]. N Engl J Med. 1977;296:1480.
20. Apter JT. The ''silent'' acute abdomen in schizophrenia. J Med Soc NJ. 1981;78:679-680.
21. Fishbain DA. Pain insensitivity in psychosis. Ann Emerg Med. 1982;11:630-632.
22. Bickerstaff LK, Harris SC, Leggett RS, et al. Pain insensitivity in schizophrenic patients. A surgical dilemma. Arch Surg. 1988; 123:49-51.
23. Rosenthal SH, Porter KA, Coffey B. Pain insensitivity in schizophrenia. Case report and review of the literature. Gen Hosp Psychiatry. 1990;12:319-322.
24. Katz E, Kluger Y, Rabinovici R, et al. Acute surgical abdominal disease in chronic schizophrenic patients: a unique clinical problem. Isr J Med Sci. 1990;26:275-277.
25. Murthy BV, Narayan B, Nayagam S. Reduced perception of pain in schizophrenia: its relevance to the clinical diagnosis of compartment syndrome. Injury. 2004;35:1192-1193.
26. Merskey H. The characteristics of persistent pain in psychological illness. J Psychosom Res. 1965;9:291-298.
27. Philips C, Hunter M. Headache in a psychiatric population. J Nerv Ment Dis. 1982;34-40.
28. Reich J, Tupin JP, Abramowitz SI. Psychiatric diagnosis of chronic pain patients. Am J Psychiatry. 1983;140:1495-1498.
29. Spear FG. Pain in psychiatric patients. J Psychosom Res. 1967;187-193.
30. Maricq HR, Edelberg R. Electrodermal recovery rate in a schizophrenic population. Psychophysiology. 1975;12:630-633.
31. Sappington J. Thresholds of shock-induced discomfort in process and reactive schizophrenics. Percept Mot Skills. 1973; 37:489-490.
32. Davis GC, Buchsbaum MS, Van Kammen DP, et al. Analgesia to pain stimuli in schizophrenics and its reversal by naltrexone. Psychiatry Res. 1979;1:61-69.
33. Earle A, Earle BV. The blood pressure response to pain and emotion in schizophrenia. J Nerv Ment Dis. 1955;121:132-139.
34. Merskey H, Gillis A, Marszalek KS. A clinical investigation of reaction to pain. J Ment Sci. 1962;347-355.
35. Gittleson NL. Psychiatric headache. A clinical study. J Ment Sci. 1961;107:403-416.
36. Kuritzky A, Mazeh D, Levi A. Headache in schizophrenic patients: a controlled study. Cephalalgia. 1999;19:725-727.
37. Watson CG, Chandarana PC, Merskey H. Relationships between pain and schizophrenia. Br J Psychiatry. 1981;138: 33-36.
38. Hinterhuber H. Headache as initial symptom of schizophrenic. Minerva Med. 1976;67:2031-2033.
39. Torrey EF. Headache in schizophrenia and seasonality of births. Biol Psychiatry. 1989;26:852-853.
40. Varsamis J, Adamson JD. Somatic symptoms in schizophrenia. Can Psychiatr Assoc J. 1976;21:1-6.
41. Lieberman AL. Painless myocardial infarction in psychotic patients. Geriatrics. 1955;10:579-580.
42. Marchand WE. Occurence of painless myocardial infarction in psychotic patients. N Engl J Med. 1955;253:51-55.
43. Marchand WE, Sarota B, Marble HC, et al. Occurence of painless acute surgical disorders in psychotic patients. N Engl J Med. 1959;260:580-585.
44. Hussard AE. Coronary heart disease in chronic schizophrenic patients: a clinicopathologic study. Circulation. 1965;31:919-929.
45. Hussard AE. Leading causes of death in institutionalized chronic schizophrenic patients: a study of 1.275 autopsy protocols. J Nerv Ment Dis. 1966;142:45-57.
46. Ballenger JC, Post RM, Sternberg DE, et al. Headaches after lumbar puncture and insensitivity. N Engl J Med. 1979; 301:110.
47. Torrey EF. Headache after lumbar puncture and insensibility to pain in psychiatric patients. N Engl J Med. 1979;301:110.
48. Blumensohn R, Ringler D, Eli I. Pain perception in patients with schizophrenia. J Nerv Ment Dis. 2002;190:481-483.
49. Hall K, Stride E. The varying response to pain in psychiatric disorders: a study in abnormal psychology. Br J Abnorm Psychol. 1954;27:48-60.
50. Hermesh H, Shiloh R, Epstein Y, et al. Heat intolerance in patients with chronic schizophrenia maintained with antipsychotic drugs. Am J Psychiatry. 2000;157:1327-1329.
51. Kudoh A, Ishihara H, Matsuki A. Current perception thresholds and postoperative pain in schizophrenic patients. Reg Anesth Pain Med. 2000;25:475-479.
52. Collins LW, Stone LA. Pain, sensitivity, age, and activity level in chronic schizophrenics and in normal. Br J Psychiatry. 1966;112:33-35.
53. Dworkin RH, Clark WC, Lipsitz JD, et al. Affective deficit and pain insensivity in schizophrenia. Motiv Emotion. 1993;17: 247-276.
54. Guieu R, Samuelian JC, Coulouvrat H. Objective evaluation of pain perception in patients with schizophrenia. Br J Psychiatry. 1994;164:253-255.
55. Bender L, Schilder P. Unconditioned and conditioned reactions to pain in schizophrenia. Am J Psychiatry. 1930;10: 365-384.
56. May PRA. Pupillary abnomalities in schizophrenia and during muscular effort. J Ment Sci. 1948;94:89-98.
57. Malmo RB, Shagass C, Smith AA. Reponsiveness in chronic schizophrenia. J Pers. 1951;19:359-375.
58. Kane EM, Nutter RW, Weckowicz TE. Response to cutaneous pain in mental hospital patients. J Abnorm Psychol. 1971;7: 305-312.
59. Davis GC, Buchsbaum MS, Naber D, et al. Effects of opiates and opiates antagonists on somatosensory evoked potentials in patients with schizophrenia and normal adults. Adv Biol Psychiatr. 1980;4:73-80.
60. Davis GC, Buchsbaum MS. Pain sensitivity and endorphins in functional psychoses. Mod Probl Pharmacopsychiatry. 1981;17: 97-108.
61. Albus M, Ackenheil M, Engel RR, et al. Situational reactivity of autonomic functions in schizophrenic patients. Psychiatry Res. 1982;6:361-370.
62. Buchsbaum MS, DeLisi LE, Holcomb HH, et al. Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Arch Gen Psychiatry. 1984;41:1159-1166.
63. Bar KJ, Jochum T, Hager F, et al. Painful hallucinations and somatic delusions in a patient with the possible diagnosis of neuroborreliosis. Clin J Pain. 2005;21:362-363.
64. Shakibai SV, Johnson JP, Bourgeois JA. Paranoid delusions and cognitive impairment suggesting Fahr's disease. Psychosomatics. 2005;46:569-572.
65. Nader R, Oberlander TF, Chambers CT, et al. Expression of pain in children with autism. Clin J Pain. 2004;20:88-97.
66. Fanurik D, Koh JL, Schmitz ML, et al. Children with cognitive impairment: parent report of pain and coping. J Dev Behav Pediatr. 1999;20:228-234.
67. LaChapelle DL, Hadjistavropoulos T, Craig KD. Pain measurement in persons with intellectual disabilities. Clin J Pain. 1999;15:13-23.
68. McGrath PJ, Rosmus C, Canfield C, et al. Behaviours caregivers use to determine pain in non-verbal, cognitively impaired individuals. Dev Med Child Neurol. 1998;40:340-343.
69. Oberlander TF, O'Donnell ME, Montgomery CJ. Pain in children with significant neurological impairment. J Dev Behav Pediatr. 1999;20:235-243.
70. Fernandez E, Turk DC. Sensory and affective components of pain: separation and synthesis. Psychol Bull. 1992;112:205-217.
71. Chapman CR. Pain and perception: comparison of sensory decision theory and evoked potential methods. Res Publ Assoc Res Nerv Ment Dis. 1980;58:111-142.
72. Decina P, Mukherjee S, Caracci G, et al. Painful sensory symptoms in neuroleptic-induced extrapyramidal syndromes. Am J Psychiatry. 1992;149:1075-1080.
73. Asarnow RF, MacCrimmon DJ. Attention/information processing, neuropsychological functioning, and thought disorder during the acute and partial recovery phases of schizophrenia: a longitudinal study. Psychiatry Res. 1982;7:309-319.
74. Corrigan PW. The social perceptual deficits of schizophrenia. Psychiatry. 1997;60:309-326.
75. Koide R, Iizuka S, Fujihara K, et al. Body image, symptoms and insight in chronic schizophrenia. Psychiatry Clin Neurosci. 2002;56:9-15.
76. Heresco-Levy U, Javitt DC. The role of N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission in the pathophysiology and therapeutics of psychiatric syndromes. Eur Neuropsychopharmacol. 1998;8:141-152.
77. Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry. 1991;148: 1301-1308.
78. Buchsbaum MS, Davis GC, van Kammen D. Diagnostic classification and the endorphin hypothesis of schizophrenia. In: Baxter C, Melnechuk T, eds. Perspectives in Schizophrenia Research. New York, NY: Raven Press; 1980, pp. 177-191.
79. Pickar D, Naber D, Post RM, et al. Endorphins in the cerebrospinal fluid of psychiatric patients. Ann N Y Acad Sci. 1982;398:399-412.
80. Meltzer HY. Biological studies in psychiatrie. Schiz Bull. 1987;13:77-111.
81. Emrich HM, Hollt V, Kissling W, et al. Beta-Endorphin-like immunoreactivity in cerebrospinal fluid and plasma of patients with schizophrenia and other neuropsychiatric disorders. Pharmakopsychiatr Neuropsychopharmakol. 1979;12:269-276.
82. Lindstrom LH, Widerlov E, Gunne LM, et al. Endorphins in human cerebrospinal fluid: clinical correlations to some psychotic states. Acta Psychiatr Scand. 1978;57:153-164.
83. Rimon R, Terenius L, Kampman R. Cerebrospinal fluid endorphins in schizophrenia. Acta Psychiatr Scand. 1980;61: 395-403.
84. Ross M, Berger PA, Goldstein A. Plasma beta-endorphin immunoreactivity in schizophrenia. Science. 1979;205: 1163-1164.
85. Terenius L. Characteristics and Function of Opioids. Amsterdam: Elsevier/North Holland Biomedical Press;1968.
86. McGorry PD, Yung AR, Phillips LJ, et al. Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms. Arch Gen Psychiatry. 2002;59: 921-928.
87. Niemi LT, Suvisaari JM, Tuulio-Henriksson A, et al. Childhood developmental abnormalities in schizophrenia: evidence from high-risk studies. Schizophr Res. 2003;60:239-258.
88. Nuechterlein KH, Dawson ME, Ventura J, et al. The vulnerability/stress model of schizophrenic relapse: a longitudinal study. Acta Psychiatr Scand Suppl. 1994;382:58-64.
89. Weinberger DR. On the plausibility of ''the neurodevelopmental hypothesis'' of schizophrenia. Neuropsychopharmacology. 1996;14:1S-11S.
90. Zubin J, Spring B. Vulnerability-a new view of schizophrenia. J Abnorm Psychol. 1977;86:103-126.
91. Yung AR, Phillips LJ, Yuen HP, et al. Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. Schizophr Res. 2004;67:131-142.
92. Erlenmeyer-Kimling L, Rock D, Roberts SA, et al. Attention, memory, and motor skills as childhood predictors of schizophrenia- related psychoses: the New York High-Risk Project. Am J Psychiatry. 2000;157:1416-1422.
93. Tsuang MT, Stone WS, Faraone SV. Schizophrenia: a review of genetic studies. Harv Rev Psychiatry. 1999;7:185-207.
94. Hooley JM, Delgado ML. Pain insensitivity in the relatives of schizophrenia patients. Schizophr Res. 2001;47:265-273.