Age-associated difference in gene expression of paediatric acute myelomonocytic lineage leukaemia (FAB M4 and M5 subtypes) and its correlation with prognosis

British Journal of Haematology

Volumn 144, Issue 6, 2009, Pages 917-929

  Jo, Aoi ^a,b   Tsukimoto, Ichiro ^c   Ishii, Eiichi ^d   Asou, Norio ^e   Mitani, Sachiyo ^a   Shimada, Akira ^f   Igarashi, Takashi ^b   Hayashi, Yasuhide ^f   Ichikawa, Hitoshi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOHO UNIVERSITY   (Japan)

^d EHIME UNIVERSITY   (Japan)

^e KUMAMOTO UNIVERSITY   (Japan)

^f Gumna Children S Medical Center   (Japan)

Author keywords

Acute myeloid leukaemia; Gene expression profiling; Microarray; MLL; Prognostic factors

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE MYELOMONOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; CANCER SURVIVAL; CHILD; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GENE EXPRESSION; GENE REARRANGEMENT; HUMAN; INFANT; KARYOTYPE; MAJOR CLINICAL STUDY; MALE; MLL GENE; NEWBORN; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TUMOR GENE;

AGE FACTORS; CHILD; CHILD, PRESCHOOL; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE REARRANGEMENT; HUMANS; INFANT; LEUKEMIA, MYELOMONOCYTIC, ACUTE; MALE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 60649104272     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.07531.x     Document Type: Article

References (45)

1. Andersson, A., Olofsson, T., Lindgren, D., Nilsson, B., Ritz, C., Eden, P., Lassen, C., Rade, J., Fontes, M., Morse, H., Heldrup, J., Behrendtz, M., Mitelman, F., Hoglund, M., Johansson, B. Fioretos, T. (2005) Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations. Proceedings of the National Academy of Sciences of the United States of America, 102, 19069 19074.
2. Armstrong, S.A., Staunton, J.E., Silverman, L.B., Pieters, R., den Boer, M.L., Minden, M.D., Sallan, S.E., Lander, E.S., Golub, T.R. Korsmeyer, S.J. (2002) MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nature Genetics, 30, 41 47.
3. Ashman, L.K., Cambareri, A.C., To, L.B., Levinsky, R.J. Juttner, C.A. (1991) Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow. Blood, 78, 30 37.
4. Bond, H.M., Mesuraca, M., Carbone, E., Bonelli, P., Agosti, V., Amodio, N., De Rosa, G., Di Nicola, M., Gianni, A.M., Moore, M.S., Hata, A., Grieco, M., Morrone, G. Venuta, S. (2004) Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells. Blood, 103, 2062 2070.
5. Brown, P., McIntyre, E., Rau, R., Meshinchi, S., Lacayo, N., Dahl, G., Alonzo, T.A., Chang, M., Arececi, R.J. Small, D. (2007) The incidence and clinical significance of nucleophosmin mutations in childhood AML. Blood, 110, 979 985.
6. Bullinger, L., Dohner, K., Bair, E., Frohling, S., Schlenk, R.F., Tibshirani, R., Dohner, H. Pollack, J.R. (2004) Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. The New England Journal of Medicine, 350, 1605 1616.
7. Cazzaniga, G., Dell'Oro, M.G., Mecucci, C., Giarin, E., Masetti, R., Rossi, V., Locatelli, F., Martelli, M.F., Basso, G., Pession, A., Biondi, A. Falini, B. (2005) Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype. Blood, 106, 1419 1422.
8. Doorn-Khosrovani, S.B., Erpelinck, C., van Putten, W.L., Valk, P.J., Luytgaarde, S., Hack, R., Slater, R., Smit, E.M., Beverloo, B., Verhoef, G., Verdonck, L.F., Ossenkoppele, G.J., Sonneveld, P., de Greef, G.E., Lowenberg, B. Delwel, R. (2003) High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients. Blood, 101, 837 845.
9. Downing, J.R. Shannon, K.M. (2002) Acute leukemia: a pediatric perspective. Cancer Cell, 2, 437 445.
10. Elloul, S., Elstrand, M.K., Nesland, J.M., Trope, C.G., Kvalheim, G., Goldberg, I., Reich, R. Davidson, B. (2005) Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma. Cancer, 103, 1631 1643.
11. Falini, B., Mecucci, C., Tiacci, E., Alcalay, M., Rosati, R., Pasqualucci, L., La Starza, R., Diverio, D., Colombo, E., Santucci, A., Bigerna, B., Pacini, R., Pucciarini, A., Liso, A., Vignetti, M., Fazi, P., Meani, N., Pettirossi, V., Saglio, G., Mandelli, F., Lo-Coco, F., Pelicci, P.G. Martelli, M.F. (2005) Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. The New England Journal of Medicine, 352, 254 266.
12. Golub, T.R., Slonim, D.K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J.P., Coller, H., Loh, M.L., Downing, J.R., Caligiuri, M.A., Bloomfield, C.D. Lander, E.S. (1999) Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science, 286, 531 537.
13. Horibe, K., Tsukimoto, I. Ohno, R. (2001) Clinicopathologic characteristics of leukemia in Japanese children and young adults. Leukemia, 15, 1256 1261.
14. Inoue, K., Sugiyama, H., Ogawa, H., Nakagawa, M., Yamagami, T., Miwa, H., Kita, K., Hiraoka, A., Masaoka, T., Nasu, K., Kyo, T., Dohy, H., Nakauchi, H., Ishidate, T., Akiyama, T. Kishimoto, T. (1994) WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia. Blood, 84, 3071 3079.
15. Iwai, T., Yokota, S., Nakao, M., Okamoto, T., Taniwaki, M., Onodera, N., Watanabe, A., Kikuta, A., Tanaka, A., Asami, K., Sekine, I., Mugishima, H., Nishimura, Y., Koizumi, S., Horikoshi, Y., Mimaya, J., Ohta, S., Nishikawa, K., Iwai, A., Shimokawa, T., Nakayama, M., Kawakami, K., Gushiken, T., Hyakuna, N., Katano, N., Tsurusawa, M. Fujimoto, T. (1999) Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. Leukemia, 13, 38 43.
16. Kawasaki, H., Isoyama, K., Eguchi, M., Hibi, S., Kinukawa, N., Kosaka, Y., Oda, T., Oda, M., Nishimura, S., Imaizumi, M., Okamura, T., Hongo, T., Okawa, H., Mizutani, S., Hayashi, Y., Tsukimoto, I., Kamada, N. Ishii, E. (2001) Superior outcome of infant acute myeloid leukemia with intensive chemotherapy: results of the Japan Infant Leukemia Study Group. Blood, 98, 3589 3594.
17. Kohlmann, A., Schoch, C., Schnittger, S., Dugas, M., Hiddemann, W., Kern, W. Haferlach, T. (2004) Pediatric acute lymphoblastic leukemia (ALL) gene expression signatures classify an independent cohort of adult ALL patients. Leukemia, 18, 63 71.
18. Kohlmann, A., Schoch, C., Dugas, M., Schnittger, S., Hiddemann, W., Kern, W. Haferlach, T. (2005) New insights into MLL gene rearranged acute leukemias using gene expression profiling: shared pathways, lineage commitment, and partner genes. Leukemia, 19, 953 964.
19. Krishnamachary, B., Zagzag, D., Nagasawa, H., Rainey, K., Okuyama, H., Baek, J.H. Semenza, G.L. (2006) Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Research, 66, 2725 2731.
20. Martineau, M., Berger, R., Lillington, D.M., Moorman, A.V. Secker-Walker, L.M. (1998) The t(6;11)(q27;q23) translocation in acute leukemia: a laboratory and clinical study of 30 cases. Leukemia, 12, 788 791.
21. Meshinchi, S., Woods, W.G., Stirewalt, W.D., Sweetser, D.A., Buckley, J.D., Tjoa, T.K., Bernstein, I.D. Radich, J.P. (2001) Prevalence and prognostic significance of FLT3 internal tandem duplication in pediatric acute myeloid leukemia. Blood, 97, 89 94.
22. Miyoshi, A., Kitajima, Y., Sumi, K., Sato, K., Hagiwara, A., Koga, Y. Miyazaki, K. (2004) Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. British Journal of Cancer, 90, 1265 1273.
23. Mowat, D.R., Wilson, M.J. Goossens, M. (2003) Mowat-Wilson syndrome. Journal of Medical Genetics, 40, 305 310.
24. Mullighan, C.G., Goorha, S., Radtke, I., Miller, C.B., Coustan-Smith, E., Dalton, J.D., Girtman, K., Mathew, S., Ma, J., Pounds, S.B., Su, X., Pui, C.H., Relling, M.V., Evans, W.E., Shurtleff, S.A. Downing, J.R. (2007) Genome-wide analysis of genetic alterations in acute lymphoblastic leukemia. Nature, 446, 758 764.
25. Nagao, T. (1995) Footprints of the Children's Leukemia Study Group of Japan. The Japanese Journal of Pediatric Hematology, 9, 332 340.
26. Pallisgaard, N., Hokland, P., Riishoj, D.C., Pedersen, B. Jorgensen, P. (1998) Multiplex reverse transcription-polymerase chain reaction for simultaneous screening of 29 translocations and chromosomal aberrations in acute leukemia. Blood, 92, 574 588.
27. Paschka, P., Marucci, G., Ruppert, A.S., Mrozek, K., Chen, H., Kittles, R.A., Vukosavljevic, T., Perrotti, D., Vardiman, J.W., Carroll, A.J., Kolitz, J.E., Larson, R.A. Bloomfield, C.D. (2006) Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. Journal of Clinical Oncology, 24, 3904 3911.
28. Pui, C.H., Kane, J.R. Crist, W.M. (1995) Biology and treatment of infant leukemias. Leukemia, 9, 762 769.
29. Pui, C.H., Raimondi, S.C., Srivastava, D.K., Tong, X., Behm, F.G., Razzouk, B., Rubnitz, J.E., Sandlund, J.T., Evans, W.E. Ribeiro, R. (2000) Prognostic factors in infants with acute myeloid leukemia. Leukemia, 14, 684 687.
30. Pui, C.H., Gaynon, P.S., Boyett, J.M., Chessells, J.M., Baruchel, A., Kamps, W., Silverman, L.B., Biondi, A., Harms, D.O., Vilmer, E., Schrappe, M. Camitta, B. (2002) Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region. Lancet, 359, 1909 1915.
31. Ross, M.E., Mahfouz, R., Onciu, M., Liu, H., Zhou, X., Song, G., Shurtleff, S.A., Pounds, S., Cheng, C., Ma, J., Ribeiro, R.C., Rubnitz, J.E., Girtman, K., Williams, W.K., Raimondi, S.C., Liang, D.C., Shih, L.Y., Pui, C.H. Downing, J.R. (2004) Gene expression profiling of pediatric acute myelogeneous leukemia. Blood, 104, 3679 3687.
32. Salto-Tellez, M., Shelat, S.G., Benoit, B., Rennert, H., Carroll, M., Leonard, D.G., Nowell, P. Bagg, A. (2003) Multiplex RT-PCR for the detection of leukemia-associated translocations. Journal of Molecular Diagnostics, 5, 231 236.
33. Satake, N., Maseki, N., Nishiyama, M., Kobayashi, H., Sakurai, M., Inaba, H., Katano, N., Horikoshi, Y., Eguchi, H., Miyake, M., Seto, M. Kaneko, Y. (1999) Chromosome abnormalities and MLL rearrangements in acute myeloid leukemia of infants. Leukemia, 13, 1013 1017.
34. Schoch, C., Kohlmann, A., Schnittger, S., Brors, B., Dugas, M., Mergenthaler, S., Kern, W., Hiddemann, W., Eils, R. Haferlach, T. (2002) Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles. Proceedings of the National Academy of Sciences of the United States of America, 99, 10008 10013.
35. Shimada, A., Taki, T., Tabuchi, K., Tawa, A., Horibe, K., Tsuchida, M., Hanada, R., Tsukimoto, I. Hayashi, Y. (2006) KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group. Blood, 107, 1806 1809.
36. Taki, T., Ida, K., Bessho, F., Hanada, R., Kikuchi, A., Yamamoto, K., Sako, M., Tsuchida, M., Seto, M., Ueda, R. Hayashi, Y. (1996) Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia. Leukemia, 10, 1303 1307.
37. Tsukimoto, I., Tawa, A., Hanada, R., Tabuchi, K., Kigasawa, H., Tsuchiya, S., Tsuchida, M., Yabe, H., Nakayama, H., Kudo, K., Kobayashi, R., Hamamoto, K., Imaizumi, M., Morimoto, A. Horibe, K. (2005) Excellent outcome of risk stratified treatment for childhood acute myeloid leukemia-AML99 trial. For the Japanese Childhood AML Cooperative Study Group. Blood, 106 Abstract 889).
38. Tsutsumi, S., Taketani, T., Nishimura, K., Ge, X., Taki, T., Sugita, K., Ishii, E., Hanada, R., Ohki, M., Aburatani, H. Hayashi, Y. (2003) Two distinct gene expression signatures in pediatric acute lymphoblastic leukemia with MLL rearrangements. Cancer Research, 63, 4882 4887.
39. Tusher, V.G., Tibshirani, R. Chu, G. (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proceedings of the National Academy of Sciences of the United States of America, 98, 5116 5121.
40. Valk, P.J., Verhaak, R.G., Beijen, M.A., Erpelinck, C.A., Doorn-Khosrovani, S.B., Boer, J.M., Beverloo, H.B., Moorhouse, M.J., van der Spek, P.J., Lowenberg, B. Delwel, R. (2004) Prognostically useful gene-expression profiles in acute myeloid leukemia. The New England Journal of Medicine, 350, 1617 1628.
41. Wakamatsu, N., Yamada, Y., Yamada, K., Ono, T., Nomura, N., Taniguchi, H., Kitoh, H., Mutoh, N., Yamanaka, T., Mushiake, K., Kato, K., Sonta, S. Nagaya, M. (2001) Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease. Nature Genetics, 27, 369 370.
42. Weisser, M., Kern, W., Rauhut, S., Schoch, C., Hiddemann, W., Haferlach, T. Schnittger, S. (2005) Prognostic impact of RT-PCR-based quantification of WT1 gene expression during MRD monitoring of acute myeloid leukemia. Leukemia, 19, 1416 1423.
43. Welbron, J.L., Jenks, H.M. Hagemeijer, A. (1993) Unique clinical features and prognostic significance of the translocation (6;11) in acute leukemia. Cancer Genetics and Cytogenetics, 65, 125 129.
44. Yagi, T., Morimoto, A., Eguchi, M., Hibi, S., Sako, M., Ishii, E., Mizutani, S., Imashuku, S., Ohki, M. Ichikawa, H. (2003) Identification of a gene expression signature associated with pediatric AML prognosis. Blood, 102, 1849 1856.
45. Yeoh, E.J., Ross, M.E., Shurtleff, S.A., Williams, W.K., Patel, D., Mahfouz, R., Behm, F.G., Raimondi, S.C., Relling, M.V., Patel, A., Cheng, C., Campana, D., Wilkins, D., Zhou, X., Li, J., Liu, H., Pui, C.H., Evans, W.E., Naeve, C., Wong, L. Downing, J.R. (2002) Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell, 1, 133 143.