메뉴 건너뛰기




Volumn 203, Issue 1, 2009, Pages 75-81

Newly developed PPAR-α agonist (R)-K-13675 inhibits the secretion of inflammatory markers without affecting cell proliferation or tube formation

Author keywords

Cell proliferation; Inflammatory markers; PPAR agonist; Subtype selectivity; Tube formation

Indexed keywords

AUTACOID; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; K 13675; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; RANTES; UNCLASSIFIED DRUG;

EID: 60649100215     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.05.055     Document Type: Article
Times cited : (17)

References (24)
  • 1
    • 10044241682 scopus 로고    scopus 로고
    • A potent activator of PPARalpha and gamma reduces the vascular cell recruitment and inhibits the intimal thickening in hypercholesterolemic rabbits
    • Seki N., Bujo H., Jiang M., et al. A potent activator of PPARalpha and gamma reduces the vascular cell recruitment and inhibits the intimal thickening in hypercholesterolemic rabbits. Atherosclerosis 178 (2005) 1-7
    • (2005) Atherosclerosis , vol.178 , pp. 1-7
    • Seki, N.1    Bujo, H.2    Jiang, M.3
  • 2
    • 0035528852 scopus 로고    scopus 로고
    • PPARgamma and atherosclerosis: effects on cell growth and movement
    • Hsueh W.A., and Law R.E. PPARgamma and atherosclerosis: effects on cell growth and movement. Arterioscler Thromb Vasc Biol 21 (2001) 1891-1895
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1891-1895
    • Hsueh, W.A.1    Law, R.E.2
  • 3
    • 34547597709 scopus 로고    scopus 로고
    • PPARalpha in atherosclerosis and inflammation
    • Zandbergen F., and Plutzky J. PPARalpha in atherosclerosis and inflammation. Biochim Biophys Acta 1771 (2007) 972-982
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 972-982
    • Zandbergen, F.1    Plutzky, J.2
  • 4
    • 23644456172 scopus 로고    scopus 로고
    • Therapeutic roles of peroxisome proliferator-activated receptor agonists
    • Staels B., and Fruchart J.C. Therapeutic roles of peroxisome proliferator-activated receptor agonists. Diabetes 54 (2005) 2460-2470
    • (2005) Diabetes , vol.54 , pp. 2460-2470
    • Staels, B.1    Fruchart, J.C.2
  • 5
    • 33746066382 scopus 로고    scopus 로고
    • Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors
    • Ichihara S., Obata K., Yamada Y., et al. Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors. J Mol Cell Cardiol 41 (2006) 318-329
    • (2006) J Mol Cell Cardiol , vol.41 , pp. 318-329
    • Ichihara, S.1    Obata, K.2    Yamada, Y.3
  • 6
    • 0033990516 scopus 로고    scopus 로고
    • Platelets induce alterations of chemotactic and adhesive properties of endothelial cells mediated through an interleukin-1-dependent mechanism. Implications for atherogenesis
    • Gawaz M., Brand K., Dickfeld T., et al. Platelets induce alterations of chemotactic and adhesive properties of endothelial cells mediated through an interleukin-1-dependent mechanism. Implications for atherogenesis. Atherosclerosis 148 (2000) 75-85
    • (2000) Atherosclerosis , vol.148 , pp. 75-85
    • Gawaz, M.1    Brand, K.2    Dickfeld, T.3
  • 7
    • 1942505215 scopus 로고    scopus 로고
    • Chemokines and atherosclerosis
    • Sheikine Y., and Hansson G.K. Chemokines and atherosclerosis. Ann Med 36 (2004) 98-118
    • (2004) Ann Med , vol.36 , pp. 98-118
    • Sheikine, Y.1    Hansson, G.K.2
  • 8
    • 0242661399 scopus 로고    scopus 로고
    • IL-6, TNF-alpha and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort
    • Haddy N., Sass C., Droesch S., et al. IL-6, TNF-alpha and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort. Atherosclerosis 170 (2003) 277-283
    • (2003) Atherosclerosis , vol.170 , pp. 277-283
    • Haddy, N.1    Sass, C.2    Droesch, S.3
  • 9
    • 20444381299 scopus 로고    scopus 로고
    • Interferon-gamma and atherosclerosis: pro- or anti-atherogenic?
    • Harvey E.J., and Ramji D.P. Interferon-gamma and atherosclerosis: pro- or anti-atherogenic?. Cardiovasc Res 67 (2005) 11-20
    • (2005) Cardiovasc Res , vol.67 , pp. 11-20
    • Harvey, E.J.1    Ramji, D.P.2
  • 11
    • 31044456529 scopus 로고    scopus 로고
    • CCR2 modulates inflammatory and metabolic effects of high-fat feeding
    • Weisberg S.P., Hunter D., Huber R., et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116 (2006) 115-124
    • (2006) J Clin Invest , vol.116 , pp. 115-124
    • Weisberg, S.P.1    Hunter, D.2    Huber, R.3
  • 12
    • 0037195465 scopus 로고    scopus 로고
    • PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4
    • Kintscher U., Lyon C., Wakino S., et al. PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4. Circ Res 91 (2002) e35-44
    • (2002) Circ Res , vol.91
    • Kintscher, U.1    Lyon, C.2    Wakino, S.3
  • 13
    • 0037423555 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages
    • Chinetti G., Lestavel S., Fruchart J.C., et al. Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages. Circ Res 92 (2003) 212-217
    • (2003) Circ Res , vol.92 , pp. 212-217
    • Chinetti, G.1    Lestavel, S.2    Fruchart, J.C.3
  • 14
    • 0038137626 scopus 로고    scopus 로고
    • High density lipoprotein-induced angiogenesis requires the activation of Ras/MAP kinase in human coronary artery endothelial cells
    • Miura S., Fujino M., Matsuo Y., et al. High density lipoprotein-induced angiogenesis requires the activation of Ras/MAP kinase in human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol 23 (2003) 802-808
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 802-808
    • Miura, S.1    Fujino, M.2    Matsuo, Y.3
  • 15
    • 0037738524 scopus 로고    scopus 로고
    • Transactivation of KDR/Flk-1 by the B2 receptor induces tube formation in human coronary endothelial cells
    • Miura S., Matsuo Y., and Saku K. Transactivation of KDR/Flk-1 by the B2 receptor induces tube formation in human coronary endothelial cells. Hypertension 41 (2003) 1118-1123
    • (2003) Hypertension , vol.41 , pp. 1118-1123
    • Miura, S.1    Matsuo, Y.2    Saku, K.3
  • 16
    • 0022499236 scopus 로고
    • Basement membrane complexes with biological activity
    • Kleinman H.K., McGarvey M.L., Hassell J.R., et al. Basement membrane complexes with biological activity. Biochemistry 25 (1986) 312-318
    • (1986) Biochemistry , vol.25 , pp. 312-318
    • Kleinman, H.K.1    McGarvey, M.L.2    Hassell, J.R.3
  • 17
    • 33847021451 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level
    • Hiuge A., Tenenbaum A., Maeda N., et al. Effects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level. Arterioscler Thromb Vasc Biol 27 (2007) 635-641
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 635-641
    • Hiuge, A.1    Tenenbaum, A.2    Maeda, N.3
  • 18
    • 33947728699 scopus 로고    scopus 로고
    • Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials
    • Nissen S.E., Nicholls S.J., Wolski K., et al. Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials. JAMA 297 (2007) 1362-1373
    • (2007) JAMA , vol.297 , pp. 1362-1373
    • Nissen, S.E.1    Nicholls, S.J.2    Wolski, K.3
  • 19
    • 35248816864 scopus 로고    scopus 로고
    • Tesaglitazar, a dual peroxisome proliferator-activated receptor alpha/gamma agonist, reduces atherosclerosis in female low density lipoprotein receptor deficient mice
    • Chira E.C., McMillen T.S., Wang S., et al. Tesaglitazar, a dual peroxisome proliferator-activated receptor alpha/gamma agonist, reduces atherosclerosis in female low density lipoprotein receptor deficient mice. Atherosclerosis (2007)
    • (2007) Atherosclerosis
    • Chira, E.C.1    McMillen, T.S.2    Wang, S.3
  • 20
    • 0032484123 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging
    • Poynter M.E., and Daynes R.A. Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem 273 (1998) 32833-32841
    • (1998) J Biol Chem , vol.273 , pp. 32833-32841
    • Poynter, M.E.1    Daynes, R.A.2
  • 21
    • 0036727448 scopus 로고    scopus 로고
    • The role of PPARs in atherosclerosis
    • Duval C., Chinetti G., Trottein F., et al. The role of PPARs in atherosclerosis. Trends Mol Med 8 (2002) 422-430
    • (2002) Trends Mol Med , vol.8 , pp. 422-430
    • Duval, C.1    Chinetti, G.2    Trottein, F.3
  • 22
    • 21644436821 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future
    • van Raalte D.H., Li M., Pritchard P.H., et al. Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future. Pharm Res 21 (2004) 1531-1538
    • (2004) Pharm Res , vol.21 , pp. 1531-1538
    • van Raalte, D.H.1    Li, M.2    Pritchard, P.H.3
  • 23
    • 33847366561 scopus 로고    scopus 로고
    • Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents
    • Sierra M.L., Beneton V., Boullay A.B., et al. Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. J Med Chem 50 (2007) 685-695
    • (2007) J Med Chem , vol.50 , pp. 685-695
    • Sierra, M.L.1    Beneton, V.2    Boullay, A.B.3
  • 24
    • 34249012461 scopus 로고    scopus 로고
    • Gypenoside XLIX, a naturally occurring PPAR-alpha activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells
    • Huang T.H., Tran V.H., Roufogalis B.D., et al. Gypenoside XLIX, a naturally occurring PPAR-alpha activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells. Eur J Pharmacol 565 (2007) 158-165
    • (2007) Eur J Pharmacol , vol.565 , pp. 158-165
    • Huang, T.H.1    Tran, V.H.2    Roufogalis, B.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.