Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis

Molecular Microbiology

Volumn 71, Issue 5, 2009, Pages 1102-1116

  Sala, Claudia ^a   Haouz, Ahmed ^b   Saul, Frederick A ^b   Miras, Isabelle ^b   Rosenkrands, Ida ^c   Alzari, Pedro M ^b   Cole, Stewart T ^a  

^a EPFL   (Switzerland)

^b CNRS   (France)

^c STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMOXICILLIN; BETA LACTAMASE; MEMBRANE PROTEIN; PROTEIN BLAI; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CELL WALL; CRYSTAL STRUCTURE; ENZYME SYNTHESIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; REGULON; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; STAPHYLOCOCCUS AUREUS; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BETA-LACTAMASES; BETA-LACTAMS; CHROMATIN IMMUNOPRECIPITATION; DNA FOOTPRINTING; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; REGULON; RNA, BACTERIAL; SEQUENCE ALIGNMENT;

MYCOBACTERIUM TUBERCULOSIS; STAPHYLOCOCCUS AUREUS;

EID: 60649096132     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2008.06583.x     Document Type: Article

References (42)

1. Anonymous (2006) The Global Plan to Stop TB 2006-2015. Geneva : World Health Organization.
2. Boshoff, H.I., Myers, T.G., Copp, B.R., McNeil, M.R., Wilson, M.A. Barry, C.E., 3rd (2004) The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action. J Biol Chem 279 : 40174 40184.
3. Chambers, H.F., Moreau, D., Yajko, D., Miick, C., Wagner, C., Hackbarth, C., et al. (1995) Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis? Antimicrob Agents Chemother 39 : 2620 2624.
4. Chambers, H.F., Turner, J., Schecter, G.F., Kawamura, M. Hopewell, P.C. (2005) Imipenem for treatment of tuberculosis in mice and humans. Antimicrob Agents Chemother 49 : 2816 2821.
5. Cole, S.T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., et al. (1998) Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393 : 537 544.
6. Cole, S.T., Eiglmeier, K., Parkhill, J., James, K.D., Thomson, N.R., Wheeler, P.R. et al. (2001) Massive gene decay in the leprosy bacillus. Nature 409 : 1007 1011.
7. DeLano, W.L. (2002) The PyMol Molecular Graphics System. Palo Alto, CA : DeLano Scientific.
8. Emsley, P. Cowtan, K. (2004) Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 60 : 2126 2132.
9. Gandhi, N.R., Moll, A., Sturm, A.W., Pawinski, R., Govender, T., Lalloo, U., et al. (2006) Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 368 : 1575 1580.
10. Garcia-Castellanos, R., Mallorqui-Fernandez, G., Marrero, A., Potempa, J., Coll, M. Gomis-Ruth, F.X. (2004) On the transcriptional regulation of methicillin resistance: MecI repressor in complex with its operator. J Biol Chem 279 : 17888 17896.
11. Garcia-Castellanos, R., Marrero, A., Mallorqui-Fernandez, G., Potempa, J., Coll, M. Gomis-Ruth, F.X. (2003) Three-dimensional structure of MecI. Molecular basis for transcriptional regulation of staphylococcal methicillin resistance. J Biol Chem 278 : 39897 39905.
12. Godsey, M.H., Baranova, N.N., Neyfakh, A.A. Brennan, R.G. (2001) Crystal structure of MtaN, a global multidrug transporter gene activator. J Biol Chem 276 : 47178 47184.
13. Grainger, D.C., Hurd, D., Harrison, M., Holdstock, J. Busby, S.J. (2005) Studies of the distribution of Escherichia coli cAMP-receptor protein and RNA polymerase along the E. coli chromosome. Proc Natl Acad Sci USA 102 : 17693 17698.
14. Gregory, P.D., Lewis, R.A., Curnock, S.P. Dyke, K.G. (1997) Studies of the repressor (BlaI) of beta-lactamase synthesis in Staphylococcus aureus. Mol Microbiol 24 : 1025 1037.
15. Hugonnet, J.E. Blanchard, J.S. (2007) Irreversible inhibition of the Mycobacterium tuberculosis beta-lactamase by clavulanate. Biochemistry 46 : 11998 12004.
16. Jarlier, V. Nikaido, H. (1990) Permeability barrier to hydrophilic solutes in Mycobacterium chelonei. J Bacteriol 172 : 1418 1423.
17. Jarlier, V., Gutmann, L. Nikaido, H. (1991) Interplay of cell wall barrier and beta-lactamase activity determines high resistance to beta-lactam antibiotics in Mycobacterium chelonae. Antimicrob Agents Chemother 35 : 1937 1939.
18. Karls, R.K., Guarner, J., McMurray, D.N., Birkness, K.A. Quinn, F.D. (2006) Examination of Mycobacterium tuberculosis sigma factor mutants using low-dose aerosol infection of guinea pigs suggests a role for SigC in pathogenesis. Microbiology 152 : 1591 1600.
19. Lim, D., Poole, K. Strynadka, N.C. (2002) Crystal structure of the MexR repressor of the mexRAB-oprM multidrug efflux operon of Pseudomonas aeruginosa. J Biol Chem 277 : 29253 29259.
20. Maxam, A.M. Gilbert, W. (1977) A new method for sequencing DNA. Proc Natl Acad Sci USA 74 : 560 564.
21. Murshudov, G.N., Vagin, A.A. Dodson, E.J. (1997) Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr 53 : 240 255.
22. Navaza, J. (1994) AMoRe: an automated program for molecular replacement. Acta Crystallogr D Biol Crystallogr A 50 : 157 163.
23. Perrakis, A., Morris, R. Lamzin, V.S. (1999) Automated protein model building combined with iterative structure refinement. Nat Struct Biol 6 : 458 463.
24. Rengarajan, J., Bloom, B.R. Rubin, E.J. (2005) Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Natl Acad Sci USA 102 : 8327 8332.
25. Rutherford, K., Parkhill, J., Crook, J., Horsnell, T., Rice, P., Rajandream, M.A. Barrell, B. (2000) Artemis: sequence visualization and annotation. Bioinformatics 16 : 944 945.
26. Safo, M.K., Ko, T.P., Musayev, F.N., Zhao, Q., Wang, A.H. Archer, G.L. (2006) Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec. Acta Crystallogr Sect F Struct Biol Cryst Commun 62 : 320 324.
27. Safo, M.K., Zhao, Q., Ko, T.P., Musayev, F.N., Robinson, H., Scarsdale, N., et al. (2005) Crystal structures of the BlaI repressor from Staphylococcus aureus and its complex with DNA: insights into transcriptional regulation of the bla and mec operons. J Bacteriol 187 : 1833 1844.
28. Sassetti, C.M. Rubin, E.J. (2003) Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci USA 100 : 12989 12994.
29. Sassetti, C.M., Boyd, D.H. Rubin, E.J. (2003) Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48 : 77 84.
30. Sharma, V.K., Hackbarth, C.J., Dickinson, T.M. Archer, G.L. (1998) Interaction of native and mutant MecI repressors with sequences that regulate mecA, the gene encoding penicillin binding protein 2a in methicillin-resistant staphylococci. J Bacteriol 180 : 2160 2166.
31. Stinear, T.P., Seemann, T., Harrison, P.F., Jenkin, G.A., Davies, J.K., Johnson, P.D., et al. (2008) Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res 18 : 729 741.
32. Stinear, T.P., Seemann, T., Pidot, S., Frigui, W., Reysset, G., Garnier, T., et al. (2007) Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Genome Res 17 : 192 200.
33. Sun, R., Converse, P.J., Ko, C., Tyagi, S., Morrison, N.E. Bishai, W.R. (2004) Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol Microbiol 52 : 25 38.
34. Terwilliger, T.C. Berendzen, J. (1999) Automated MAD and MIR structure solution. Acta Crystallogr D Biol Crystallogr 55 : 849 861.
35. Wang, F., Cassidy, C. Sacchettini, J.C. (2006) Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics. Antimicrob Agents Chemother 50 : 2762 2771.
36. Wehenkel, A., Bellinzoni, M., Grana, M., Duran, R., Villarino, A., Fernandez, P., et al. (2008) Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential. Biochim Biophys Acta 1784 : 193 202.
37. Wilke, M.S., Hills, T.L., Zhang, H.Z., Chambers, H.F. Strynadka, N.C. (2004) Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus. J Biol Chem 279 : 47278 47287.
38. Wittman, V., Lin, H.C. Wong, H.C. (1993) Functional domains of the penicillinase repressor of Bacillus licheniformis. J Bacteriol 175 : 7383 7390.
39. Yeats, C., Finn, R.D. Bateman, A. (2002) The PASTA domain: a beta-lactam-binding domain. Trends Biochem Sci 27 : 438.
40. Zhang, H.Z., Hackbarth, C.J., Chansky, K.M. Chambers, H.F. (2001) A proteolytic transmembrane signaling pathway and resistance to beta-lactams in staphylococci. Science 291 : 1962 1965.
41. Zhu, Y., Englebert, S., Joris, B., Ghuysen, J.M., Kobayashi, T. Lampen, J.O. (1992) Structure, function, and fate of the BlaR signal transducer involved in induction of beta-lactamase in Bacillus licheniformis. J Bacteriol 174 : 6171 6178.
42. Zhu, Y.F., Curran, I.H., Joris, B., Ghuysen, J.M. Lampen, J.O. (1990) Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 beta-lactamase (class D) of Salmonella typhimurium. J Bacteriol 172 : 1137 1141.