Bullous pemphigoid followed by pustular psoriasis showing Th1, Th2, Treg and Th17 immunological changes

European Journal of Dermatology

Volumn 19, Issue 1, 2009, Pages 69-71

  Yasukawa, Shinsuke ^a   Dainichi, Teruki ^b   Kokuba, Hisashi ^a   Moroi, Yoichi ^a   Urabe, Kazunori ^a   Hashimoto, Takashi ^b   Furue, Masutaka ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bullous pemphigoid; Pustular psoriasis; Th1; Th17; Th2

Indexed keywords

AUTOANTIBODY; BETAMETHASONE; CYTOKINE; ETRETINATE; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 17; INTERLEUKIN 4; MONOCLONAL ANTIBODY; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIBODY DETECTION; ARTICLE; BLOOD SAMPLING; BULLOUS PEMPHIGOID; CASE REPORT; COMORBIDITY; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE EXACERBATION; DRUG DOSE REDUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HELPER CELL; HISTOPATHOLOGY; HOSPITAL ADMISSION; HUMAN; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; JAPANESE; MALE; PATHOGENESIS; PLASMAPHERESIS; PUSTULAR PSORIASIS; REGULATORY T LYMPHOCYTE; REMISSION; SKIN BIOPSY; TH1 CELL; TH17 CELL; TH2 CELL;

ADULT; BETAMETHASONE; GLUCOCORTICOIDS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; MALE; PEMPHIGOID, BULLOUS; PSORIASIS; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 60549111590     PISSN: 11671122     EISSN: None     Source Type: Journal    
DOI: 10.1684/ejd.2008.0572     Document Type: Article

References (16)

1. Koerber Jr. WA, Price NM, Watson W. Coexistent psoriasis and bullous pemphigoid: a report of six cases. Arch Dermatol 1978; 114: 1643-6.
2. Grunwald MH, David M, Feuerman EJ. Coexistence of psoriasis vulgaris and bullous diseases. J Am Acad Dermatol 1985; 13: 224-8.
3. Sugita K, Kabashima K, Nishio D, et al. Th2 cell fluctuation in association with reciprocal occurrence of bullous pemphigoid and psoriasis vulgaris. J Eur Acad Dermatol Venereol 2007; 21: 569-70.
4. Schlaak JF, Buslau M, Jochum W, et al. T cells involved in psoriasis vulgaris belong to the Th1 subset. J Invest Dermatol 1994; 102: 145-9.
5. Austin LM, Ozawa M, Kikuchi T, et al. The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients. J Invest Dermatol 1999; 113: 752-9.
6. Schmidt E, Bastian B, Dummer R, et al. Detection of elevated levels of IL-4, IL-6, and IL-10 in blister fluid of bullous pemphigoid. Arch Dermatol Res 1996; 288: 353-7.
7. De Pita O, Frezzolini A, Cianchini G, et al. T-helper 2 involvement in the pathogenesis of bullous pemphigoid: role of soluble CD30 (sCD30). Arch Dermatol Res 1997; 289: 667-70.
8. Coffman RL. Origins of the T(H)1-T(H)2 model: a personal perspective. Nat Immunol 2006; 7: 539-41.
9. Shevach EM. Regulatory T cells in autoimmmunity. Annu Rev Immunol 2000; 18: 423-49.
10. Mangan PR, Harrington LE, O'Quinn DB, et al. Transforming Kwth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441: 231-4.
11. Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441: 235-8.
12. Weaver CT, Harrington LE, Mangan PR, et al. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 2006; 24: 677-88.
13. Steinman L. A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cel-mediated tissue damage. Nat Med 2007; 13: 139-45.
14. Zheng Y, Danilenko DM, Valdez P, et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007; 445: 648-51.
15. Haider AS, Lowes MA, Suárez-Fariñas M, et al. Identification of Cellular Pathways of "Type 1," Th17 T Cells, and TNF- and Inducible Nitric Oxide Synthase-Producing Dendritic Cells in Autoimmune Inflammation through Pharmacogenomic Study of Cyclosporine A in Psoriasis. J Immunol 2008; 180: 1913-20.
16. Lowes MA, Kikuchi T, Fuentes-Duculan J, et al. Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells. J Invest Dermatol 2008; 128: 1207-11.