Analysis of hMSH2 mismatch repair protein expression in dysplasia, carcinoma in situ and invasive squamous cell carcinoma of the vocal folds

Cancer Investigation

Volumn 27, Issue 1, 2009, Pages 38-46

  Hussein, Mahmoud Rezk A ^a   Aref, Essam Eldin M ^b   Yassen, Dalia G ^b   Ramadan, Mostafa O ^a  

^a Assiut University   (Egypt)

^b ASSIUT UNIVERSITY   (Egypt)

Author keywords

Mismatch repair; Proteins and vocal folds

Indexed keywords

MISMATCH REPAIR PROTEIN; PROTEIN MSH2;

ADULT; ARTICLE; CANCER INVASION; CARCINOMA IN SITU; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; EPITHELIUM DYSPLASIA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPEROXIDASE STAINING; IMMUNOREACTIVITY; LARYNGEAL BIOPSY; LARYNX CARCINOMA; MALE; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SCORING SYSTEM; SQUAMOUS CELL CARCINOMA; VOCAL CORD;

CARCINOMA IN SITU; CARCINOMA, SQUAMOUS CELL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPERPLASIA; IMMUNOENZYME TECHNIQUES; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; VOCAL CORDS;

EID: 60549111227     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.1080/07357900802139951     Document Type: Article

References (24)

1. Hussein, M.R. Alterations of p53 and Bcl-2 protein expression in the laryngeal intraepithelial neoplasia. Cancer Biol Ther 2005, 4(2), 213-217.
2. Ha, P.K.; Pilkington, T.A.; Westra, W.H.; Sciubba, J.; Sidransky, D.; Califano, J.A. Progression of microsatellite instability from premalignant lesions to tumors of the head and neck. Int J Cancer 2002, 102(6), 615-617.
3. Demokan, S.; Suoglu, Y.; Demir, D.; Gozeler, M.; Dalay, N. Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer. Ann Oncol 2006, 17(6), 995-999.
4. Hussein, M.R.; Wood, G.S. Building bridges in cancer: mismatch repair and microsatellite instability. Am J Dermatopathol 2002, 24(1), 76-81.
5. Hussein, M.R.; Haemel, A.K.; Albert, D.M.; Wood, G.S. Microsatellite instability and alterations of mismatch repair protein expression in choroidal melanomas. Arch Ophthalmol 2005, 123(12), 1705-1711.
6. Friedlander, P.L. Genomic instability in head and neck cancer patients. Head Neck 2001, 23(8), 683-691.
7. Nunn, J.; Nagini, S.; Risk, J.M.; Prime, W.; Maloney, P.; Liloglou, T.; et al. Allelic imbalance at the DNA mismatch repair loci, hMSH2, hMLH1, hPMS1, hPMS2, and hMSH3, in squamous cell carcinoma of the head and neck. Oral Oncol 2003, 39(2), 115-129.
8. Smigiel, R.; Stembalska-Kozlowska, A.; Mirghomizadeh, F.; Krecicki, T.; Zatonski, T.; Ramsey, D.; et al. Correlation among loss of heterozygosity, promoter methylation, and protein expression of MLH1 in larynx cancer. Oncol Rep 2004, 11(3), 707-710.
9. Wu, D.; Fu, W.; Jiang, L.; Zhang, X.; Li, F.; Guo, X.; et al. [Loss of heterozygosity and microsatellite instability in laryngeal carcinoma near p16 gene]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 1999, 16(2), 99-102.
10. Sanz-Ortega, J.; Valor, C.; Saez, M.C.; Ortega, L.; Sierra, E.; Poch, J.; et al. 3p21, 5q21, 9p21, and 17p13 allelic deletions accumulate in the dysplastic spectrum of laryngeal carcinogenesis and precede malignant transformation. Histol Histopathol 2003, 18(4), 1053-1057.
11. Hussein, M.R.; Sun, M.; Roggero, E.; Sudilovsky, E.C.; Tuthill, R.J.; Wood, G.S.; et al. Loss of heterozygosity, microsatellite instability, and mismatch repair protein alterations in the radial growth phase of cutaneous malignant melanomas. Mol Carcinog 2002, 34(1), 35-44.
12. Spitz, M.R.; Wei, Q.; Li, G.; Wu, X. Genetic susceptibility to tobacco carcinogenesis. Cancer Invest 1999, 17(8), 645-659.
13. Hoeijmakers, J.H. Human nucleotide excision repair syndromes: molecular clues to unexpected intricacies. Eur J Cancer 1994, 30A(13), 1912-1921.
14. Hussein, M.R.; Ismael, H.H. Alterations of p53, Bcl-2, and hMSH2 protein expression in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas in the upper Egypt. Cancer Biol Ther 2004, 3(10), 983-988.
15. Hussein, M.R. Genetic pathways to melanoma tumorigenesis. J Clin Pathol 2004, 57(8), 797-801.
16. Wei, Q.; Cheng, L.; Hong, W.K.; Spitz, M.R. Reduced DNA repair capacity in lung cancer patients. Cancer Res 1996, 56(18), 4103-4107.
17. Sheridan, T.B.; Fenton, H.; Lewin, M.R.; Burkart, A.L.; Iacobuzio-Donahue, C.A.; Frankel, W.L.; Montgomery, E. Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions "caught in the act." Am J Clin Pathol 2006, 126(4), 564-571.
18. Fogt, F.; Zimmerman, R.L.; Poremba, C.; Noffsinger, A.E.; Alsaigh, N.; Rueschoff, J. Immunohistochemical screening of mismatch repair genes hMLH1, hMSH2, and hMSH6 in dysplastic lesions of the colon. Appl Immunohistochem Mol Morphol 2002, 10(1), 57-61.
19. Handra-Luca, A.; Couvelard, A.; Degott, C.; Flejou, J.F. Correlation between patterns of DNA mismatch repair hMLH1 and hMSH2 protein expression and progression of dysplasia in intraductal papillary mucinous neoplasms of the pancreas. Virchows Arch 2004, 444(3), 235-238.
20. Kubo, N.; Yashiro, M.; Ohira, M.; Hori, T.; Fujiwara, I.; Hirakawa, K. Frequent microsatellite instability in primary esophageal carcinoma associated with extraesophageal primary carcinoma. Int J Cancer 2005, 114(2), 166-173.
21. El-Naggar, A.K.; Hurr, K.; Huff, V.; Clayman, G.L.; Luna, M.A.; Batsakis, J.G. Microsatellite instability in preinvasive and invasive head and neck squamous carcinoma. Am J Pathol 1996, 148(6), 2067-2072.
22. Hussein, M.R.; Roggero, E.; Sudilovsky, E.C.; Tuthill, R.J.; Wood, G.S.; Sudilovsky, O. Alterations of mismatch repair protein expression in benign melanocytic nevi, melanocytic dysplastic nevi, and cutaneous malignant melanomas. Am J Dermatopathol 2001, 23(4), 308-314.
23. Hussein, M.R.; Wood, G.S. hMLH1 and hMSH2 gene mutations are present in radial growth-phase cutaneous malignant melanoma cell lines and can be induced further by ultraviolet-B irradiation. Exp Dermatol 2003, 12(6), 872-75.
24. Hussein, M.R. Alterations of p53, Bcl-2, and hMSH2 protein expression in the cirrhotic, macroregenerative, dysplastic nodules, and hepatocellular carcinomas in Upper Egypt. Liver Int 2004, 24(6), 552-560.