Spleen R2 and R2* in iron-overloaded patients with sickle cell disease and thalassemia major

Journal of Magnetic Resonance Imaging

Volumn 29, Issue 2, 2009, Pages 357-364

  Brewer, Casey J ^a,b   Coates, Thomas D ^a   Wood, John C ^a,b,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CHLA   (United States)

Author keywords

Iron; MRI; Sickle cell; Spleen; Thalassemia

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; FEMALE; HEART; HUMAN; IRON OVERLOAD; KIDNEY; LIVER; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SICKLE CELL ANEMIA; SPLEEN; THALASSEMIA MAJOR;

ADOLESCENT; ADULT; ANEMIA, SICKLE CELL; BETA-THALASSEMIA; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INFANT; IRON OVERLOAD; KIDNEY; LIVER; MAGNETIC RESONANCE IMAGING; MALE; MYOCARDIUM; PANCREAS; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; SPLEEN;

EID: 60549109901     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.21666     Document Type: Article

References (40)

1. Pippard MJ. Iron overload and iron chelation therapy in thalas-saemia and sickle cell haemoglobinopathies. Acta Haematol 1987; 78:206-211.
2. Vichinsky EP. Current issues with blood transfusions in sickle cell disease. Semin Hematol 2001;38:14-22.
3. Zurlo MG, De Stefano P, Borgna-Pignatti C, et al. Survival and causes of death in thalassaemia major. Lancet 1989;2:27-30.
4. Au WY, Lam WW, Chu W, et al. A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major. Haemato-logica 2008;93:116-119.
5. Schein A, Enriquez C, Coates TD, Wood JC. Magnetic resonance detection ofkidney iron deposition in sickle cell disease: a marker of chronic hemolysis. J Magn Reson Imaging 2008;28:698-704.
6. St Pierre TG, Clark PR, Chua-anusorn W, et al. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 2005;105:855-861.
7. Wood JC, Enriquez C, Ghugre N, et al. MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 2005;106:1460-1465.
8. Wood JC, Tyszka JM, Ghugre N, Carson S, Nelson MD, Coates TD. Myocardial iron loading in transfusion-dependent thalassemia and sickle-cell disease. Blood 2004;103:1934-1936.
9. Fischer R, Tiemann CD, Engelhardt R, et al. Assessment of iron stores in children with transfusion siderosis by biomagnetic liver susceptometry. Am J Hematol 1999;60:289-299.
10. Chua-anusorn W, Macey DJ, Webb J, de la Motte Hall P, St Pierre TG. Effects of prolonged iron loading in the rat using both paren-teral and dietary routes. Biometals 1999;12:103-113.
11. Tanimoto A, Oshio K, Suematsu M, Pouliquen D, Stark DD. Relaxation effects of clustered particles. J Magn Reson Imaging 2001;14: 72-77.
12. Tanimoto A, Pouliquen D, Kreft BP, Stark DD. Effects of spatial distribution on proton relaxation enhancement by particulate iron oxide. J Magn Reson Imaging 1994;4:653-657.
13. Siegelman ES, Mitchell DG, Rubin R, et al. Parenchymal versus reticuloendothelial iron overload in the liver: distinction with MR imaging [see Comments]. Radiology 1991;179:361-366.
14. Siegelman ES, Outwater E, Hanau CA, et al. Abdominal iron distribution in sickle cell disease: MR findings in transfusion and nontransfusion dependent patients. J Comput Assist Tomogr 1994;18:63-67.
15. Ghugre NR, Enriquez CM, Coates TD, Nelson MD Jr, Wood JC. Improved R2* measurements in myocardial iron overload. J Magn Reson Imaging 2006;23:9-16.
16. Zuyderhoudt FM, Hengeveld P, van Gool J, Jorning GG. A method for measurement of liver iron fractions in needle biopsy specimens and some results in acute liver disease. Clin Chim Acta 1978;86:313-321.
17. Nowak D, Pietras T, Antczak A, Krol M, Piasecka G. Effect of bacterial lipopolysaccharide on the content of lipid peroxidation products in lungs and other organs of mice. Antonie Van Leeuwenhoek 1993;63:77-83.
18. Wood J, Aguilar M, Otto-Duessel M, Nick H, Nelson M, Moats R. Influence of iron chelation therapy on R1 and R2 calibration curves in gerbil liver and heart. Magn Reson Med 2008;60:82-89.
19. Wood JC, Fassler J, Meade T. Mimicking liver iron overload using liposomal ferritin preparations. Magn Reson Med 2004;51:607-611.
20. Borgna-Pignatti C, De Stefano P, Bongo IG, Avato F, Cazzola M. Spleen iron content is low in thalassemia. Am J Pediatr Hematol Oncol 1984;6:340-343.
21. Weisskoff RM, Zuo CS, Boxerman JL, Rosen BR. Microscopic susceptibility variation and transverse relaxation: theory and experiment. Magn Reson Med 1994;31:601-610.
22. Ghugre NR, Coates TD, Nelson MD, Wood JC. Mechanisms oftissueiron relaxivity: nuclear magnetic resonance studies of human liver biopsy specimens. Magn Reson Med 2005;54:1185-1193.
23. Harmatz P, Butensky E, Quirolo K, et al. Severity of iron overload in patients with sickle cell disease receiving chronic red blood cell transfusion therapy. Blood 2000;96:76-79.
24. Papanikolaou G, Tzilianos M, Christakis JI, et al. Hepcidin in iron overload disorders. Blood 2005;105:4103-4105.
25. Walter PB, Fung EB, Killilea DW, et al. Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease. Br J Haematol 2006;135:254-263.
26. Schlesinger AE, Edgar KA, Boxer LA. Volume of the spleen in children as measured on CTscans: normal standards as a function of body weight. AJR Am J Roentgenol 1993;160:1107-1109.
27. Kaneko J, Sugawara Y, Matsui Y, Makuuchi M. Spleen size of live donors for liver transplantation. Surg Radiol Anat 2008;30:515-518.
28. Yoshizumi T, Taketomi A, Kayashima H, et al. Estimation of standard liver volume for Japanese adults. Transplant Proc 2008;40: 1456-1460.
29. Emy P, Levin T, Sheth S, Ruzal-Shapiro C, Grarvin J, Berdon W. Iron overload in reticuloendothelial systems of pediatric oncology patients who have undergone transfusions: MR observations. AJR Am J Roentgenol 1997;168:1011-1016.
30. Yoon DY, Choi BI, Han JK, Han MC, Park MO, Suh SJ. MR findings of secondary hemochromatosis: transfusional vs erythropoiectic. J Comput Assist Tomogr 1994;18:416-419.
31. Arrive L, Thurnher S, Hricak H, Price DC. Magnetic resonance imaging of splenic iron overload. Eur J Radiol 1990;10:98-104.
32. Papakonstantinou O, Drakonaki EE, Maris T, Vasiliadou A, Papadakis A, Gourtsoyiannis N. MR imaging ofspleen in beta-thalas-semia major. Abdom Imaging 2006 (in press).
33. Drakonaki EE, Maris TG, Papadakis A, Karantanas AH. Bone marrow changes in beta-thalassemia major: quantitative MR imaging findings and correlation with iron stores. Eur Radiol 2007;17:2079-2087.
34. Gossuin Y, Muller RN, Gillis P, Bartel L. Relaxivities of human liver and spleen ferritin. Magn Reson Imaging 2005;23:1001-1004.
35. Siegelman ES, Mitchell DG, Semelka RC. Abdominal iron deposition: metabolism, MR findings, and clinical importance. Radiology 1996;199:13-22.
36. Origa R, Galanello R, Ganz T, et al. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica 2007;92:583-588.
37. Gladwin MT, Schechter AN. Nitric oxide therapy in sickle cell disease. Semin Hematol 2001;38:333-342.
38. St Pierre TG, Dickson DP, Kirkwood JK, Ward RJ, Peters TJ. A Mossbauer spectroscopic study of the form of iron in iron overload. Biochim Biophys Acta 1987;924:447-451.
39. St Pierre TG, Chua-anusorn W, Webb J, Macey D, Pootrakul P. The form of iron oxide deposits in thalassemic tissues varies between different groups of patients: a comparison between Thai beta-thalassemia/hemoglobin E patients and Australian beta-thalassemia patients. Biochim Biophys Acta 1998;1407:51-60.
40. Phrommintikul A, Sukonthasarn A, Kanjanavanit R, Nawarawong W. Splenectomy: a strong risk factor for pulmonary hypertension in patients with thalassaemia. Heart 2006;92:1467-1472.