Prolonged survival of microencapsulated neonatal porcine islet xenografts in immune-competent mice without antirejection therapy

Cell Transplantation

Volumn 17, Issue 10-11, 2008, Pages 1243-1256

  Kobayashi, Tsunehiro ^a,b   Arefanian, Hossein ^a,c   Harb, George ^a   Tredget, Eric B ^a   Rajotte, Ray V ^a   Korbutt, Gregory S ^a   Rayat, Gina R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NARA MEDICAL UNIVERSITY   (Japan)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Immune modulation; Islet transplantation; Maturation; Microencapsulation; Neonatal porcine islets; Type 1 diabetes

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; DNA CONTENT; INSULIN RELEASE; MICROENCAPSULATION; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; STREPTOZOCIN DIABETES; SURVIVAL RATE; SWINE; ANIMAL; BAGG ALBINO MOUSE; DRUG FORMULATION; EVALUATION; FEMALE; GENETICS; GRAFT SURVIVAL; IMMUNOCOMPETENCE; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; MALE; METHODOLOGY; MOUSE MUTANT; NEWBORN; PANCREAS ISLET; PHYSIOLOGY; TIME; TRANSGENIC MOUSE;

MUS; SUS;

LYST PROTEIN, MOUSE; PROTEIN;

ANIMALS; ANIMALS, NEWBORN; DRUG COMPOUNDING; FEMALE; GRAFT SURVIVAL; IMMUNOCOMPETENCE; IMMUNOSUPPRESSION; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, INBRED BALB C; MICE, SCID; MICE, TRANSGENIC; PROTEINS; SWINE; TIME FACTORS;

EID: 60549101092     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368908787236602     Document Type: Article

References (27)

1. Binette, T. M.; Dufour, J. M.; Korbutt, G. S. In vitro maturation of neonatal porcine islets: a novel model for the study of islet development and xenotransplantation. Ann. NY Acad. Sci. 944:47-61; 2001.
2. Cardona, K.; Korbutt, G. S.; Milas, Z.; Lyon, J.; Cano, J.; Jiang, W.; Bello-Laborn, H.; Hacquoil, B.; Strobert, E.; Gangappa, S.; Weber, C. J.; Pearson, T. C.; Rajotte, R. V.; Larsen, C. P. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat. Med. 12:304-306; 2006.
3. Cerilli, J.; Brasile, L.; Galouzis, T.; Lempert, N.; Clarke, J. The vascular endothelial cell antigen system. Transplantation 39:286-289; 1985.
4. Cooper, D. K. C.; Ye, Y.; Rolf, J. L. L.; Zuhdi, N. The pig as a potential organ donor for man. In: Cooper, D. K. C.; Kemp, E.; Reemtsma, K.; White, D. J. G., eds. Xenotransplantation: The transplantation of organs and tissues between species. Berlin: Springer-Verlag; 1995: 481-499.
5. Ferry, B.; Halttunen, J.; Leszczynski, D.; Schellekens, H.; vd Meide, P. H.; Hayry, P. Impact of class II major histocompatibility complex antigen expression on the immunogenic potential of isolated rat vascular endothelial cells. Transplantation 44:499-503; 1987.
6. Hering, B. J.; Wijkstrom, M.; Graham, M. L.; Hardstedt, M.; Aasheim, T. C.; Jie, T.; Ansite, J. D.; Nakano, M.; Cheng, J.; Li, W.; Moran, K.; Christians, U.; Finnegan, C.; Mills, C. D.; Sutherland, D. E.; Bansal-Pakala, P.; Murtaugh, M. P.; Kirchhof, N.; Schuuman, H.-J. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed non-human primates. Nat. Med. 12:301-303; 2006.
7. Hinegardner, R. T. An improved fluorometric assay for DNA. Anal. Biochem. 39:197-201; 1971.
8. Kin, T.; Korbutt, G. S.; Kobayashi, T.; Dufour, J. M.; Rajotte, R. V. Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets. Diabetes 54:1032-1039; 2005.
9. Kobayashi, T.; Harb, G.; Rayat, G. R. Prolonged survival of microencapsulated neonatal porcine islets in mice treated with a combination of anti-CD154 and anti-LFA-1 monoclonal antibodies. Transplantation 80:821-827; 2005.
10. Kobayashi, T.; Harb, G.; Rajotte, R. V.; Korbutt, G. S.; Mallett, A. G.; Arefanian, H.; Mok, D.; Rayat, G. R. Immune mechanisms associated with the rejection of microencapsulated neonatal porcine islet xenografts. Xenotransplantation 13:547-559; 2006.
11. Korbutt, G. S.; Elliott, J. E; Ao, Z.; Smith, D. K.; Warnock, G. L.; Rajotte, R. V. Large scale isolation, growth, and function of porcine neonatal islet cells. J. Clin. Invest. 97: 2119-2129; 1996.
12. Korbutt, G. S.; Ao, Z.; Rayat, G. R.; Flashner, M.; Rajotte, R. V. Effect of microencapsulation and autologous serum on the growth and maturation of neonatal porcine islets in vitro. Acta Diabetologica 34:136; 1997.
13. Korbutt, G. S.; Rayat, G. R.; Rajotte, R. V.; Kieffer, T. J. Culture of microencapsulated neonatal porcine islets is associated with an increased proportion of ß cells/cellular insulin content and elevated expression of IDX-1. Diabetes 48(Suppl. 1):474; 1999.
14. Korbutt, G. S.; Rayat, G. R.; Rajotte, R. V.; Kieffer, T. J. In vitro expansion of neonatal porcine islet cells is associated with elevated expression of IDX-1 and NKX2.2. Diabetologia 42(Suppl. 1):151; 2002.
15. Maki, T.; O'Neil, J. J.; Porter, J.; Mullon, C. J.; Solomon, B. A.; Monaco, A. P. Porcine islets for xenotransplantation. Transplantation 62:136-138; 1996.
16. Omer, A.; Duvivier-Kali, V. F.; Trivedi, N.; Wilmot, K.; Bonner-Weir, S.; Weir, G. C. Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. Diabetes 52:69-75; 2003.
17. Rayat, G. R.; Johnson, Z. A.; Beilke, J. N.; Korbutt, G. S.; Rajotte, R. V.; Gill, R. G. The degree of phylogenetic disparity of islet grafts dictates the reliance on indirect CD4 T-cell antigen recognition for rejection. Diabetes 52:1433-1440; 2003.
18. Rayat, G. R.; Gill, R. G. Indefinite survival of neonatal porcine islet xenografts by simultaneous targeting of LFA-1 and CD154 or CD45RB. Diabetes 54:443-451; 2005.
19. Rayat, G. R.; Rajotte, R. V.; Hering, B. J.; Binette, T. M.; Korbutt, G. S. In vitro and in vivo expression of Gala-(l,3)Gal on porcine islet cells is age dependent. J. Endocrinol. 177:127-135; 2003.
20. Rayat, G. R.; Rajotte, R. V.; Ao, Z.; Korbutt, G. S. Microencapsulation of neonatal porcine islets: Protection from human antibody/complement-mediated cytolysis in vitro and long-term reversal of diabetes in nude mice. Transplantation 69:1084-1090; 2000.
21. Roitt, I.; Brostoff, J.; Male, D. Immunology, 6th ed. London: Harcourt Publishers; 2001.
22. Rood, P. P.; Buhler, L. H.; Bottino, R.; Trucco, M.; Cooper, D. K. C. Pig-to-nonhuman primate islet xenotransplantation: A review of current problems. Cell Transplant. 15:89-104; 2006.
23. Ryan, E. A.; Lakey, J. R.; Rajotte, R. V.; Korbutt, G. S.; Kin, T.; Imes, S.; Rabinovitch, A.; Elliott, J. F.; Bigam, D.; Kneteman, N. M.; Wamock, G. L.; Larsen, I.; Shapiro, A. M. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 50: 710-719; 2001.
24. Shapiro, A. M. J.; Lakey, J. R. T.; Ryan, E. A.; Korbutt, G. S.; Toth, E.; Wamock, G. L.; Kneteman, N. M.; Rajotte, R. V. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343:230-238; 2000.
25. Trivedi, N.; Hollister-Lock, J.; Lopez-Avalos, M. D.; O'Neil, J. J.; Keegan, M.; Bonner-Weir, S.; Weir, G. C. Increase in ß-cell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of ß-cells and differentiation of duct cells. Endocrinology 142: 2115-2122; 2001.
26. Veng, L. M.; Bjugstad, K. B.; Freed, C. R.; Marrack, P.; Clarkson, E. D.; Bell, K.; Hutt, C.; Zawada, W. M. Xeno- grafts of MHC-deficient mouse embryonic mesencephalon improve behavioral recovery in hemiparkinsonian rats. Cell Transplant. 11:5-16; 2002.
27. Yoon, K. H.; Quickel, R. R.; Tatarkiewicz, K.; Ulrich, T. R.; Hollister-Lock, J.; Trivedi, N.; Bonner-Weir, S.; Weir, G. C. Differentiation and expansion of beta cell mass in porcine neonatal pancreatic cell clusters transplanted into nude mice. Cell Transplant. 8:673-689; 1999.