Immune mechanisms associated with the rejection of encapsulated neonatal porcine islet xenografts

Xenotransplantation

Volumn 13, Issue 6, 2006, Pages 547-559

  Kobayashi, Tsunehiro ^a,b   Harb, George ^a   Rajotte, Ray V ^a   Korbutt, Gregory S ^a   Mallett, Aaron G ^a   Arefanian, Hossein ^a   Mok, Dereck ^a   Rayat, Gina R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

CD4+ T cell; Chemokines; Cytokines; Islet transplantation; Microencapsulation; Neonatal porcine islet

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; COMPLEMENT; CYTOKINE; GAMMA INTERFERON; HETEROANTIGEN; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 10; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CORRELATION ANALYSIS; GRAFT REJECTION; HISTOCOMPATIBILITY; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MICROENCAPSULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; SWINE; XENOGRAFT;

ANIMALS; ANIMALS, NEWBORN; BLOOD GLUCOSE; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL PROLIFERATION; CYTOKINES; DIABETES MELLITUS; GRAFT REJECTION; IMMUNITY, INNATE; IMMUNITY, NATURAL; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; RNA, MESSENGER; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 33750074132     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2006.00349.x     Document Type: Article

References (22)

1. SHAPIRO AM, LAKEY JR, RYAN EA et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230.
2. KORBUTT GS, ELLIOTT JF, AO Z et al. Large scale isolation, growth, and function of porcine neonatal islet cells. J Clin Invest 1996; 97: 2119.
3. KIN T, KORBUTT GS, KOBAYASHI T, DUFOUR JM, RAJOTTE RV. Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets. Diabetes 2005; 54: 1032.
4. CARDONA K, KORBUTT GS, MILAS Z et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 2006; 12: 304.
5. RAYAT GR, JOHNSON ZA, BEILKE JN et al. The degree of phylogenetic disparity of islet grafts dictates the reliance on indirect CD4 T-cell antigen recognition for rejection. Diabetes 2003; 52: 1433.
6. KOBAYASHI T, HARB G, RAYAT GR. Prolonged survival of microencapsulated neonatal porcine islets in mice treated with a combination of anti-CD154 and anti-LFA-1 monoclonal antibodies. Transplantation 2005; 80: 821.
7. WEBER CJ, ZABINSKI S, KOSCHITZKY T et al. The role of CD4+ helper T cells in the destruction of microencapsulated islet xenografts in NOD mice. Transplantation 1990; 49: 396.
8. XU BY, YANG H, SERREZE DV et al. Rapid destruction of encapsulated islet xenografts by NOD mice is CD4-dependent and facilitated by B-cells: innate immunity and autoimmunity do not play significant roles. Transplantation 2005; 80: 402.
9. MCKENZIE AW, GEORGIOU HM, ZHAN Y, BRADY JL, LEW AM. Protection of xenografts by a combination of immunoisolation and a single dose of anti-CD4 antibody. Cell Transplant 2001; 10: 183.
10. LOUDOVARIS T, MANDEL TE, CHARLTON B. CD4+ T cell mediated destruction of xenografts within cell-impermeable membranes in the absence of CD8+ T cells and B cells. Transplantation 1996; 61: 1678.
11. JONES KS, SEFTON MV, GORCZYNSKI RM. In vivo recognition by the host adaptive immune system of microencapsulated xenogeneic cells. Transplantation 2004; 78: 1454.
12. LANZA RP, KUHTREIBER WM, BEYER A, CHICK WL. Humoral response to encapsulated islets. Transplant Proc 1994; 26: 3346.
13. DUVIVIER-KALI VF, OMER A, LOPEZ-AVALOS MD, O'NEIL JJ, WEIR GC. Survival of microencapsulated adult pig islets in mice in spite of an antibody response. Am J Transplant 2004; 4: 1991.
14. CARLIN JM, OZAKI Y, BYRNE GI, BROWN RR, BORDEN EC. Interferons and indoleamine 2,3-dioxygenase: role in antimicrobial and antitumor effects. Experientia 1989; 45: 535.
15. TAYLOR MW, FENG GS. Relationship between interferon-gamma, indolamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J 1991; 5: 2516.
16. JANEWAY CA JR, TRAVERS P, WALPORT M, SHLOMCHIK MJ. Immunobiology: The Immune System in Health and Disease. New York, NY: Garland Science, 2005.
17. RAYAT GR, RAJOTTE RV, AO Z, KORBUTT GS. Microencapsulation of neonatal porcine islets: protection from human antibody/complement-mediated cytolysis in vitro and long-term reversal of diabetes in nude mice. Transplantation 2000; 69: 1084.
18. YI S, FENG X, HAWTHORNE WJ et al. CD4+ T cells initiate pancreatic islet xenograft rejection via an interferon-c-dependent recruitment of macrophages and natural killer cells. Transplantation 2002; 73: 437.
19. YI S, HAWTHORNE WJ, LEHNERT AM et al. T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts. J Immunol 2003; 170: 2750.
20. SIEBERS U, HORCHER A, BRANDHORST H et al. Analysis of the cellular reaction towards microencapsulated xenogeneic islets after intraperitoneal transplantation. J Mol Med 1999; 77: 215.
21. OMER A, KEEGAN M, CZISMADIA E et al. Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. Xenotransplantation 2003; 10: 240.
22. WU G, KORSGREN O, ZHANG J et al. Pig islet xenograft rejection is markedly delayed in macrophage-depleted mice: a study in streptozotocin diabetic animals. Xenotransplantation 2000; 7: 214.