Enhanced exercise capacity in mice with severe heart failure treated with an allosteric effector of hemoglobin, myo-inositol trispyrophosphate

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 6, 2009, Pages 1926-1929

  Biolo, Andreia ^a,b   Greferath, Ruth ^c,d   Siwik, Deborah A ^a,b   Qin, Fuzhong ^a,b   Valsky, Eugene ^a,b   Fylaktakidou, Konstantina C ^d,f   Pothukanuri, Srinivasu ^d   Duarte, Carolina D ^d   Schwarz, Richard P ^c   Lehn, Jean Marie ^d   Nicolau, Claude ^c,d,e   Colucci, Wilson S ^a,b  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NormOxys Inc   (United States)

^d UNIVERSITÉ LOUIS PASTEUR   (France)

^e TUFTS UNIVERSITY   (United States)

^f DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

Author keywords

Hypoxia; Oxygen delivery

Indexed keywords

DRINKING WATER; HEMOGLOBIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MYO INOSITOL TRIPYROPHOSPHATE; PYROPHOSPHORIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EXERCISE; HEART FAILURE; HEART RATE; IN VIVO STUDY; MOUSE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALLOSTERIC REGULATION; ANIMALS; EXERCISE TOLERANCE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEART FAILURE; HEMOGLOBINS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INOSITOL PHOSPHATES; MICE; MICE, TRANSGENIC; OXYGEN; RNA, MESSENGER; TREATMENT OUTCOME;

MUS; MUS MUSCULUS;

EID: 60549097684     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812381106     Document Type: Article

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