Regulation of angiotensin II type I receptor (AT1R) protein levels in the obese Zucker rat kidney and urine

Clinical and Experimental Hypertension

Volumn 31, Issue 1, 2009, Pages 49-63

  Hu, Jun ^a   Tiwari, Swasti ^a   Riazi, Shahla ^a   Hu, Xinqun ^a   Wang, Xiaoyan ^a   Ecelbarger, Carolyn M ^a,b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

Diabetes; Hypertension; Insulin resistance; RAAS; RAS

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; CANDESARTAN; MICROTUBULE ASSOCIATED PROTEIN; ROSIGLITAZONE; SODIUM CHLORIDE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME REGULATION; HYPERTENSION; INSULIN RESISTANCE; METABOLIC SYNDROME X; NONHUMAN; OBESITY; PROTEIN EXPRESSION; RAT; URINARY EXCRETION; ZUCKER RAT;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BENZIMIDAZOLES; BIOLOGICAL MARKERS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; HUMANS; HYPERTENSION; HYPOGLYCEMIC AGENTS; KIDNEY; METABOLIC SYNDROME X; OBESITY; PPAR GAMMA; RATS; RATS, ZUCKER; RECEPTOR, ANGIOTENSIN, TYPE 1; SODIUM CHLORIDE, DIETARY; TETRAZOLES; THIAZOLIDINEDIONES; THINNESS;

EID: 60549096491     PISSN: 10641963     EISSN: 15256006     Source Type: Journal    
DOI: 10.1080/10641960802409788     Document Type: Article

References (46)

1. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey. Jama 2002;287(3):356-359.
2. Sowers JR, Frohlich ED. Insulin and insulin resistance: impact on blood pressure and cardiovascular disease. Med Clin North Am 2004;88(1):63-82.
3. Engeli S. Role of the renin-angiotensin-aldosterone system in the metabolic syndrome. Contrib Nephrol 2006;151:122-134.
4. Sharma AM, Engeli S. The role of renin-angiotensin system blockade in the management of hypertension associated with the cardiometabolic syndrome. J Cardiometab Syndr 2006;1(1):29-35.
5. Manrique C, Lastra G, Whaley-Connell A, Sowers JR. Hypertension and the cardiometabolic syndrome. J Clin Hypertens (Greenwich) 2005;7(8):471-476.
6. Cooper ME, Tikellis C, Thomas MC. Preventing diabetes in patients with hypertension: One more reason to block the renin-angiotensin system. J Hypertens Suppl 2006;24(1):S57-63.
7. Vincze G, Barner JC, Bohman T, Linn WD, Wilson JP, Johnsrud MT, Worchel J, Shepherd MD. Use of antihypertensive medications among United States veterans newly diagnosed with hypertension. Curr Med Res Opin 2008; 24(3):795-805.
8. Martens FM, Visseren FL, Lemay J, de Koning EJ, Rabelink TJ. Metabolic and additional vascular effects of thiazolidinediones. Drugs 2002;62(10):1463-1480.
9. Song J, Knepper MA, Hu X, Verbalis JG, Ecelbarger CA. Rosiglitazone activates renal sodium-and water-reabsorptive pathways and lowers blood pressure in normal rats. J Pharmacol Exp Ther 2004;308(2):426-433.
10. Zhang H, Zhang A, Kohan DE, Nelson RD, Gonzalez FJ, Yang T. Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention. Proc Natl Acad Sci U S A 2005;102(26):9406-9411.
11. Chen L, Yang B, McNulty JA, Clifton LG, Binz JG, Grimes AM, Strum JC, Harrington WW, Chen Z, Balon TW, Stimpson SA, Brown KK. GI262570, a peroxisome proliferator-activated receptor {gamma} agonist, changes electrolytes and water reabsorption from the distal nephron in rats. J Pharmacol Exp Ther 2005;312(2):718-725.
12. Song J, Liu H, Ressom H, Tiwari S, Ecelbarger CM. Chronic rosiglitazone therapy normalizes expression of ACE1, SCD1, and other genes in the kidney of obese Zucker rats as determined by microarray analysis. Exp Clin Endocrinol Diabetes 2008;116:1-11.
13. Madala Halagappa VK, Tiwari S, Riazi S, Hu X, Ecelbarger CM. Chronic Candesartan alters expression and activity of NKCC2, NCC, and ENaC in the obese Zucker Rat. Am J Physiol Renal Physiol 2008;294(5):F1222-31.
14. Crowley SD, Gurley SB, Herrera MJ, Ruiz P, Griffiths R, Kumar AP, Kim HS, Smithies O, Le TH, Coffman TM. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A 2006;103(47):17985-17990.
15. Khan O, Riazi S, Hu X, Song J, Wade JB, Ecelbarger CA. Regulation of the renal thiazide-sensitive Na-Cl cotransporter, blood pressure, and natriuresis in obese Zucker rats treated with rosiglitazone. Am J Physiol Renal Physiol 2005;289(2):F442-450.
16. Alonso-Galicia M, Brands MW, Zappe DH, Hall JE. Hypertension in obese Zucker rats. Role of angiotensin II and adrenergic activity. Hypertension 1996;28(6):1047-1054.
17. Becker M, Umrani D, Lokhandwala MF, Hussain T. Increased renal angiotensin II AT1 receptor function in obese Zucker rat. Clin Exp Hypertens 2003;25(1):35-47.
18. Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 2007;59(3):251-287.
19. Erdely A, Freshour G, Maddox DA, Olson JL, Samsell L, Baylis C. Renal disease in rats with type 2 diabetes is associated with decreased renal nitric oxide production. Diabetologia 2004;47(10):1672-1676.
20. Kasiske BL, O'Donnell MP, Keane WF. The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury. Hypertension 1992;19(1 suppl):I110-I115.
21. Noda M, Matsuo T, Nagano-Tsuge H, Ohta M, Sekiguchi M, Shibouta Y, Naka T, Imura Y. Involvement of angiotensin II in progression of renal injury in rats with genetic non-insulin-dependent diabetes mellitus (Wistar fatty rats). Jpn J Pharmacol 2001;85(4):416-422.
22. Schmitz PG, O'Donnell MP, Kasiske BL, Katz SA, Keane WF. Renal injury in obese Zucker rats: glomerular hemodynamic alterations and effects of enalapril. Am J Physiol 1992;263(3 Pt 2):F496-502.
23. Sugimoto K, Tsuruoka S, Matsushita K, Fujimura A. Effects of candesartan cilexetil on oxidative state and renal function in 5/6 nephrectomized rats. J Hum Hypertens 1999;13 suppl 1:S63-70; discussion S81.
24. Topcu SO, Pedersen M, Norregaard R, Wang G, Knepper M, Djurhuus JC, Nielsen S, Jorgensen TM, Frokiaer J. Candesartan prevents long-term impairment of renal function in response to neonatal partial unilateral ureteral obstruction. Am J Physiol Renal Physiol 2007;292(2):F736-48.
25. Song J, Hu X, Shi M, Knepper MA, Ecelbarger CA. Effects of dietary fat, NaCl, and fructose on renal sodium and water transporter abundances and systemic blood pressure. Am J Physiol Renal Physiol 2004;287(6):F1204-1212.
26. Ecelbarger CA, Kim GH, Terris J, Masilamani S, Mitchell C, Reyes I, Verbalis JG, Knepper MA. Vasopressin-mediated regulation of epithelial sodium channel abundance in rat kidney. Am J Physiol Renal Physiol 2000;279(1):F46-53.
27. McKee JA, Kumar S, Ecelbarger CA, Fernandez-Llama P, Terris J, Knepper MA. Detection of Na(+) transporter proteins in urine. J Am Soc Nephrol 2000;11(11):2128-2132.
28. Riazi S, Khan O, Tiwari S, Hu X, Ecelbarger CA. Rosiglitazone regulates ENaC and Na-K-2Cl cotransporter (NKCC2) abundance in the obese Zucker rat. Am J Nephrol 2006;26(3):245-257.
29. Riazi S, Madala Halagappa VK, Dantas AP, Hu X, Ecelbarger CA. Sex differences in renal nitric oxide synthase (NOS), NAD(P)H oxidase, and blood pressure in obese Zucker rats. Gender Medicine 2007;4(3):1-16.
30. Riazi S, Madala Halagappa VK, Hu X, Ecelbarger CA. Sex and body-type interactions in the regulation of renal sodium transporter abundance, urinary excretion, and activity in lean and obese Zucker rats. Gend Med 2006;3(4):309-327.
31. Riazi S, Hu X, Madala Halagappa VK, Ecelbarger CA. Sex differences in blood pressure and kidney sodium transporters and channels in response to high salt diet in lean and obese Zucker rats. FASEB Journal 2006;20(5):A338 (Abstract).
32. Zeng C, Asico LD, Wang X, Hopfer U, Eisner GM, Felder RA, Jose PA. Angiotensin II regulation of AT1 and D3 dopamine receptors in renal proximal tubule cells of SHR. Hypertension 2003;41(3 Pt 2):724-729.
33. Xu ZG, Lanting L, Vaziri ND, Li Z, Sepassi L, Rodriguez-Iturbe B, Natarajan R. Upregulation of angiotensin II type 1 receptor, inflammatory mediators, and enzymes of arachidonate metabolism in obese Zucker rat kidney: reversal by angiotensin II type 1 receptor blockade. Circulation 2005;111(15):1962-1969.
34. Bouby N, Hus-Citharel A, Marchetti J, Bankir L, Corvol P, Llorens-Cortes C. Expression of type 1 angiotensin II receptor subtypes and angiotensin II-induced calcium mobilization along the rat nephron. J Am Soc Nephrol 1997;8(11):1658-1667.
35. Hakam AC, Hussain T. Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats. Hypertension 2005;45(2):270-275.
36. Wang DH, Du Y, Zhao H, Granger JP, Speth RC, Dipette DJ. Regulation of angiotensin type 1 receptor and its gene expression: role in renal growth. J Am Soc Nephrol 1997;8(2):193-198.
37. Molavi B, Chen J, Mehta JL. Cardioprotective effects of rosiglitazone are associated with selective overexpression of type 2 angiotensin receptors and inhibition of p42/44 MAPK. Am J Physiol Heart Circ Physiol 2006;291(2):H687-693.
38. Zanchi A, Perregaux C, Maillard M, Cefai D, Nussberger J, Burnier M. The PPARgamma agonist pioglitazone modifies the vascular sodium-angiotensin II relationship in insulin-resistant rats. Am J Physiol Endocrinol Metab 2006;291(6):E1228-1234.
39. Gaborik Z, Hunyady L. Intracellular trafficking of hormone receptors. Trends Endocrinol Metab 2004;15(6):286-293.
40. Lafayette RA, Mayer G, Park SK, Meyer TW. Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass. J Clin Invest 1992;90(3):766-771.
41. Mayer G, Lafayette RA, Oliver J, Deen WM, Myers BD, Meyer TW. Effects of angiotensin II receptor blockade on remnant glomerular permselectivity. Kidney Int 1993;43(2):346-353.
42. Riazi S, Khan O, Hu X, Ecelbarger CA. Aldosterone infusion with high-NaCl diet increases blood pressure in obese but not lean Zucker rats. Am J Physiol Renal Physiol 2006;291(3):F597-605.
43. Schmid C, Castrop H, Reitbauer J, Della Bruna R, Kurtz A. Dietary salt intake modulates angiotensin II type 1 receptor gene expression. Hypertension 1997;29(4):923-929.
44. Du Y, Yao A, Guo D, Inagami T, Wang DH. Differential regulation of angiotensin II receptor subtypes in rat kidney by low dietary sodium. Hypertension 1995;25(4 Pt 2):872-877.
45. Kitiyakara C, Chabrashvili T, Chen Y, Blau J, Karber A, Aslam S, Welch WJ, Wilcox CS. Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase. J Am Soc Nephrol 2003;14(11):2775-2782.
46. Tiwari S, Halagappa VK, Riazi S, Hu X, Ecelbarger CA. Reduced expression of insulin receptors in the kidneys of insulin-resistant rats. J Am Soc Nephrol 2007;18(10):2661-2671.