The effects of d-amphetamine on extrastriatal dopamine D2/D 3 receptors: A randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 36, Issue 3, 2009, Pages 475-483

  Aalto, Sargo ^a,b   Hirvonen, Jussi ^a   Kaasinen, Valtteri ^a   Hagelberg, Nora ^a,c   Kajander, Jaana ^a   Någren, Kjell ^a   Seppälä, Timo ^d   Rinne, Juha O ^a   Scheinin, Harry ^a   Hietala, Jarmo ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

11C FLB 457; Amphetamine; D 2 D3 receptor; Dopamine; PET; Positron emission tomography

Indexed keywords

DEXAMPHETAMINE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; ISOREMOXIPRIDE; ISOREMOXIPRIDE C 11; PLACEBO; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOPAMINE RELEASE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG RECEPTOR BINDING; EUPHORIA; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; RANDOMIZED CONTROLLED TRIAL;

ADULT; BRAIN; CARBON RADIOISOTOPES; DEXTROAMPHETAMINE; DOPAMINE; DOUBLE-BLIND METHOD; FRONTAL LOBE; GYRUS CINGULI; HIPPOCAMPUS; HUMANS; MALE; POSITRON-EMISSION TOMOGRAPHY; PYRROLIDINES; RADIOPHARMACEUTICALS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; SALICYLAMIDES; YOUNG ADULT;

EID: 60549096272     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-008-0969-9     Document Type: Article

References (41)

1. M Laruelle 2000 Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review J Cereb Blood Flow Metab 20 423 451
2. L Farde T Suhara S Nyberg P Karlsson Y Nakashima J Hietala 1997 A PET study of [C-11]FLB 457 binding to extrastriatal D-2-dopamine receptors in healthy subjects and antipsychotic drug-treated patients Psychopharmacology 133 396 404
3. C Halldin L Farde T Högberg N Mohell H Hall T Suhara 1995 Carbon-11-FLB 457: a radioligand for extrastriatal D2 dopamine receptors J Nucl Med 36 1275 1281
4. H Olsson C Halldin CG Swahn L Farde 1999 Quantification of [11C]FLB 457 binding to extrastriatal dopamine receptors in the human brain J Cereb Blood Flow Metab 19 1164 1173
5. Y-H Chou C Halldin L Farde 2000 Effect of amphetamine on extrastriatal D2 dopamine receptor binding in the primate brain: a PET study Synapse 38 138 143
6. T Okauchi T Suhara J Maeda K Kawabe S Obayashi K Suzuki 2001 Effect of endogenous dopamine on endogenous dopamine on extrastriated [(11)C]FLB 457 binding measured by PET Synapse 41 87 95
7. AJ Montgomery MC Asselin L Farde PM Grasby 2007 Measurement of methylphenidate-induced change in extrastriatal dopamine concentration using [11C]FLB 457 PET J Cereb Blood Flow Metab 27 369 377
8. N Hagelberg S Aalto J Kajander V Oikonen S Hinkka K Någren 2004 Alfentanil increases cortical dopamine D2/D3 receptor binding in healthy subjects Pain 109 86 93
9. S Aalto J Ihalainen J Hirvonen J Kajander H Scheinin H Tanila 2005 Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man Psychopharmacology (Berl) 182 375 383
10. S Aalto A Bruck M Laine K Nagren JO Rinne 2005 Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: a positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457 J Neurosci 25 2471 2477
11. I Boileau A Dagher M Leyton RN Gunn GB Baker M Diksic 2006 Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men Arch Gen Psychiatry 63 1386 1395
12. First MB, Spitzer RL, Gibbon M, Williams JB. Structured clinical interview for the DSM-IV axis I disorders. Washington DC: American Psychiatric Press; 1996.
13. DP Van Kammen DL Murphy 1975 Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment Psychopharmacology 44 215 222
14. A Kankaanpää T Gunnar K Ariniemi P Lillsunde S Mykkänen T Seppälä 2004 A single-step procedure for GC/MS screening and quantitative determination of amphetamine-type stimulants and related drugs in blood, serum, oral fluid and urine samples J Chromatogr B Analyt Technol Biomed Life Sci 810 57 68
15. M Bergström L Eriksson C Bohm G Blomqvist J Litton 1983 Correction for scattered radiation in a ring detector positron camera by integral transformation of the projections J Comput Assist Tomogr 7 42 50
16. TK Lewellen SG Kohlmyer RS Miyaoka MS Kaplan CW Sterans SF Schubert 1996 Investigation of the performance of the General Electric ADVANCE positron emission tomograph in 3D mode IEEE Trans Nucl Sci 43 2199 2206
17. K Någren P Truong S Helin A Amir C Halldin 2003 Production of high specific radioactivity [C-11]FLB 457 from target produced [C-11]methane Eur J Nucl Med 30 Suppl. 2 S217
18. H Vilkman J Kajander K Nagren V Oikonen E Syvalahti J Hietala 2000 Measurement of extrastriatal D2-like receptor binding with [11C]FLB 457 - a test-retest analysis Eur J Nucl Med 27 1666 1673
19. AA Lammertsma SP Hume 1996 Simplified reference tissue model for PET receptor studies Neuroimage 4 153 158
20. RB Innis VJ Cunningham J Delforge M Fujita A Gjedde RN Gunn 2007 Consensus nomenclature for in vivo imaging of reversibly binding radioligands J Cereb Blood Flow Metab 27 1533 1539
21. H Olsson C Halldin L Farde 2004 Differentiation of extrastriatal dopamine D2 receptor density and affinity in the human brain using PET Neuroimage 22 794 803
22. MC Asselin AJ Montgomery PM Grasby SP Hume 2007 Quantification of PET studies with the very high-affinity dopamine D2/D3 receptor ligand [11C]FLB 457: re-evaluation of the validity of using a cerebellar reference region J Cereb Blood Flow Metab 27 378 392
23. RN Gunn AA Lammertsma SP Hume VJ Cunningham 1997 Parametric imaging of ligand-receptor binding using a simplified reference region model Neuroimage 6 279 287
24. KJ Friston AP Holmes KJ Worsley J-B Poline CD Frith RSJ Frackowiak 1995 Statistical parametric maps in functional imaging: a general linear approach Hum Brain Mapp 2 189 210
25. B Moghaddam CW Berridge PS Goldman-Rakic BS Bunney RH Roth 1993 In vivo assessment of basal and drug-induced dopamine release in cortical and subcortical regions of the anesthetized primate Synapse 13 215 222
26. A Verma B Moghaddam 1996 NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine J Neurosci 16 373 379
27. B Adams B Moghaddam 1998 Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine J Neurosci 18 5545 5554
28. JR Shoblock EB Sullivan IM Maisonneuve SD Glick 2003 Neurochemical and behavioral differences between d-methamphetamine and d-amphetamine in rats Psychopharmacology 165 359 369
29. JR Shoblock IM Maisonneuve SD Glick 2004 Differential interactions of desipramine with amphetamine and methamphetamine: evidence that amphetamine releases dopamine from noradrenergic neurons in the medial prefrontal cortex Neurochem Res 29 1437 1442
30. P Riccardi R Li MS Ansari D Zald S Park B Dawant 2006 Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humans Neuropsychopharmacology 31 1016 1026
31. VL Cropley RB Innis PJ Nathan AK Brown JL Sangare A Lerner 2008 Small effect of dopamine release and no effect of dopamine depletion on [(18)F]fallypride binding in healthy humans Synapse 62 399 408
32. ED Morris KK Yoder 2007 Positron emission tomography displacement sensitivity: predicting binding potential change for positron emission tomography tracers based on their kinetic characteristics J Cereb Blood Flow Metab 27 606 617
33. D Martinez M Slifstein A Broft O Mawlawi DR Hwang Y Huang 2003 Imaging human mesolimbic dopamine transmission with positron emission tomography. II. Amphetamine-induced dopamine release in the functional subdivisions of the striatum J Cereb Blood Flow Metab 23 285 300
34. A Breier TP Su R Saunders RE Carson BS Kolachana A de Bartolomeis 1997 Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method Proc Natl Acad Sci U S A 94 2569 2974
35. M Slifstein M Laruelle 2001 Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers Nucl Med Biol 28 595 608
36. A Dagher R Gunn G Lockwood VJ Cunningham PM Grasby DJ Brooks 1998
37. H Olsson L Farde 2001 Potentials and pitfalls using high affinity radioligands in PET and SPET determinations on regional drug induced D2 receptor occupancy - a simulation study based on experimental data Neuroimage 14 4 936 945
38. H Hall L Farde C Halldin YL Hurd S Pauli G Sedvall 1996 Autoradiographic localization of extrastriatal D2-dopamine receptors in the human brain using [125I]epidepride Synapse 23 115 123
39. J Delforge M Bottlaender S Pappata C Loc'h A Syrota 2001 Absolute quantification by positron emission tomography of the endogenous ligand J Cereb Blood Flow Metab 21 613 630
40. M Willeit N Ginovart A Graff P Rusjan I Vitcu S Houle 2008 First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission tomography study Neuropsychopharmacology 33 279 289
41. P Piccini N Pavese DJ Brooks 2003 Endogenous dopamine release after pharmacological challenges in Parkinson's disease Ann Neurol 53 647 653