Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein
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NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols
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NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
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Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport
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Genetic variations and treatments that affect the lifespan of the NPC1 mouse
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Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
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Lysosomal unesterified cholesterol content correlates with liver cell death in murine Niemann-Pick type C disease
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Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse
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Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: Insights on normal metabolism of HDL and LDL gained from the NP-C mutation
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