Synthesis and radiation stability of novel biologically active sulfur compounds derived from 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane

Farmaco

Volumn 55, Issue 5, 2000, Pages 354-361

  Ghorab, M M ^a   El Sharief, A M Sh ^b   Ammar, Y A ^b   Mohamed, Sh I ^b  

^a NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

^b Al Azhar University   (Egypt)

Author keywords

Rays; Antifungal activity; Triazoles; Triazolothiadiazine; Triazolothiadiazole

Indexed keywords

1 [4 FORMYLAMINO 5 MERCAPTO TRIAZOLO 3 YL] 2 [4' AMINO 5 MERCAPTO TRIAZOLO 3 YL]ETHANE; 1,2 BIS[4 CYCLOHEXENYLAMINO 5 CYCLOHENENYLTHIO TRIAZOLO 3 YL]ETHANE; 1,2 BIS[5 ANILINO TRIAZOLO(3,4B)(1,3,4) THIADIAZOLO 3 YL]ETHANE; 1,2 BIS[5,7 DIPHENYL TRIAZOLO(3,4B)(1,3,4) THIADIAZEPINO 3 YL]ETHANE; ETHYLENE DERIVATIVE; SULFUR DERIVATIVE; TRIAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; DRUG STABILITY; DRUG SYNTHESIS; EGYPT; NONHUMAN; RADIOSENSITIVITY;

ANTIFUNGAL AGENTS; DRUG STABILITY; GAMMA RAYS; MICROBIAL SENSITIVITY TESTS; SPECTRUM ANALYSIS; STERILIZATION; TRIAZOLES;

EID: 0033821150     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(00)00051-3     Document Type: Article

References (12)

1. Mohan J., Anjaneyulu G.S.R., Sudhir S., Arora D.R. Heterocyclic synthesis containing bridgehead nitrogen atom. Reactions of p-bis(5-mercapto-4-amino-s-triazol-3-yl)phenylene with chloroacetaldehyde diethylacetal, benzoin, chloroacetic acid, carbon disulphide and 2,3-dichloroquinoxaline. J. Indian Chem. Soc. 66:1989;330-331.
2. Singh H., Yadav L.D.S., Bhattacharya B.K. Synthesis of some new bis(1,2,4-triazol-3-yl)-disulphides, sulphides and sulphones as potential pesticide. J. Indian Chem. Soc. 56:1979;1013-1016.
3. Goswami B.N., Kataky J.C.S., Baruah J.N. Synthesis and biological activity of bridgehead nitrogen heterocycles. J. Heterocycl. Chem. 23:1986;1439-1442.
4. Holla B.S., Kalluraya B. Synthesis of some substituted 4-(5-nitro-2-furfurylideneamino)-5-mercapto-1,2,4-triazoles and 7H-6-(5-nitro-2-furyl)-s-triazolo[3,4b]thiadiazines. Indian J. Chem., Sect. B. 27:1988;683-685.
5. George T., Mehta D.V., Tahilramani R., David J., Talwalker P.K. Synthesis of some s-triazoles with potential analgetic and antiinflammatory activites. J. Med. Chem. 14:1971;335-338.
6. S. Giri, H. Singh, L.D.S. Yadav, R.K. Khare, Synthesis of some new 1,3,4-oxa(thia)diazoles and 1,2,4-triazoles as potential fungicides, J. Indian Chem. Soc. 55 (1978) 168-171.
7. Mody M.K., Prasad A.R., Ramalingham T., Suttur P.B. Synthesis and pharmacology of 2-aryl-5-aryloxyalkyl-s-triazolo[3,4b]-1,3,4-thiadiazoles. J. Indian Chem. Soc. 59:1982;769-770.
8. Ghorab M.M., Abdel-Hamide S.G., Ali G.M., El-Sayed, Shaurub H. Synthesis and insecticidal activity of some new 3-[4(3H)-quinazolinone-2-yl)thiomethyl]-1,2,4-triazole-5-thiols. Pestic. Sci. 48:1996;31-35.
9. Ghorab M.M., Abdel-Hamide S.G., El-Gaby M.S.A., El-Sayed S.M. Synthesis and effect of some new [1,2,4]triazolo[4,3a]quinazolin-5(4H)-ones and related compounds on Ehrlich Ascites carcinoma cells. Acta Pharm. 49:1999;1-10.
10. Jacobs G.P. A review of the effect of gamma radiation on pharmaceuticals materials. J. Biomed. Appl. 10:1995;59-96.
11. Boess C., Bogl K.W. Influence of radiation treatment on pharmaceuticals: a review alkaloids, morphine derivatives and antibiotics. Drug Dev. Ind. Pharm. 22:1996;495-529.
12. Reeves D.S., White: L.O. Principles of Methods of Assaying Antibiotic in Pharmaceutical Microbiology. third ed. 1983;140-162 Blackwell Scientific, Oxford.