메뉴 건너뛰기




Volumn , Issue , 2005, Pages 81-112

Cell Metabolism

Author keywords

[No Author keywords available]

Indexed keywords


EID: 85134987985     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9780849351068-7     Document Type: Chapter
Times cited : (13)

References (138)
  • 1
    • 85120090450 scopus 로고    scopus 로고
    • Cell culture technology-an overview
    • Ozturk SS, ed, New York: Taylor and Francis
    • Ozturk SS. Cell culture technology-an overview. In: Ozturk SS, ed. Cell Culture Technology. New York: Taylor and Francis, 2005:1.
    • (2005) Cell Culture Technology , pp. 1
    • Ozturk, S.S.1
  • 2
    • 85064693121 scopus 로고    scopus 로고
    • Metabolic control of animal cell culture processes
    • Hauser H, Wagner R, eds, Berlin: Walter de Gruyter
    • Wagner R. Metabolic control of animal cell culture processes. In: Hauser H, Wagner R, eds. Mammalian Cell Biotechnology in Protein Production. Berlin: Walter de Gruyter, 1997:193.
    • (1997) Mammalian Cell Biotechnology in Protein Production , pp. 193
    • Wagner, R.1
  • 3
    • 2442612236 scopus 로고    scopus 로고
    • Cell metabolism, animal
    • Spier R, ed, New York: John Wiley & Sons
    • Häggström L. Cell metabolism, animal. In: Spier R, ed. Encyclopedia of Cell Technology. New York: John Wiley & Sons, 2000:392.
    • (2000) Encyclopedia of Cell Technology , pp. 392
    • Häggström, L.1
  • 4
    • 0026607990 scopus 로고
    • Mammalian facilitative glucose transporter family. Structure and molecular regulation
    • Pessin JE, Bell GI. Mammalian facilitative glucose transporter family. Structure and molecular regulation. Annu Rev Physiol 1992; 54:911.
    • (1992) Annu Rev Physiol , vol.54 , pp. 911
    • Pessin, J.E.1    Bell, G.I.2
  • 5
    • 0025036574 scopus 로고
    • Facilitated diffusion of glucose
    • Carruthers A. Facilitated diffusion of glucose. Physiol Rev 1990; 70:1135.
    • (1990) Physiol Rev , vol.70 , pp. 1135
    • Carruthers, A.1
  • 6
    • 0018672517 scopus 로고
    • Kinetics of 3-O-methyl-D-glucose transport in isolated rat hepatocytes
    • Craik JD, Elliot KRF. Kinetics of 3-O-methyl-D-glucose transport in isolated rat hepatocytes. Biochem J 1979; 182:503.
    • (1979) Biochem J , vol.182 , pp. 503
    • Craik, J.D.1    Elliot, K.R.F.2
  • 7
    • 0025886960 scopus 로고
    • Expression of human glucose transporters in Xenopus oocytes. Kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms
    • Gould GW, Thomas HM, Jess TJ, Bell GI. Expression of human glucose transporters in Xenopus oocytes. Kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms. Biochemistry 1991; 30:5139.
    • (1991) Biochemistry , vol.30 , pp. 5139
    • Gould, G.W.1    Thomas, H.M.2    Jess, T.J.3    Bell, G.I.4
  • 8
    • 0023812475 scopus 로고
    • Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues
    • Kayano T, Fukumoto H, Eddy RL, Fan YS, Byers MG, Shows TB, Bell GI. Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. J Biol Chem 1988; 263:15245.
    • (1988) J Biol Chem , vol.263 , pp. 15245
    • Kayano, T.1    Fukumoto, H.2    Eddy, R.L.3    Fan, Y.S.4    Byers, M.G.5    Shows, T.B.6    Bell, G.I.7
  • 9
    • 0026624835 scopus 로고
    • Facilitative glucose transporters. Regulatory mechanisms and de-regulation in diabetes
    • Kahn BB. Facilitative glucose transporters. Regulatory mechanisms and de-regulation in diabetes. J Clin Invest 1992; 89:1367.
    • (1992) J Clin Invest , vol.89 , pp. 1367
    • Kahn, B.B.1
  • 10
  • 11
    • 0026782099 scopus 로고
    • Cloning and expression of a hepatic microsomal glucose transport protein
    • Waddell ID, Zomerschoe AG, Voice MW, Burchell A. Cloning and expression of a hepatic microsomal glucose transport protein. Biochem J 1992; 286:173.
    • (1992) Biochem J , vol.286 , pp. 173
    • Waddell, I.D.1    Zomerschoe, A.G.2    Voice, M.W.3    Burchell, A.4
  • 12
    • 0028484019 scopus 로고
    • Examination of primary metabolic pathways in a murine hybridoma with carbon-13 nuclear magnetic resonance spectroscopy
    • Mancuso A, Sharfstein ST, Tucker SN, Clark DS, Blanch HW. Examination of primary metabolic pathways in a murine hybridoma with carbon-13 nuclear magnetic resonance spectroscopy. Biotechnol Bioeng 1994; 44:563.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 563
    • Mancuso, A.1    Sharfstein, S.T.2    Tucker, S.N.3    Clark, D.S.4    Blanch, H.W.5
  • 13
    • 0027692808 scopus 로고
    • Glucose and glutamine metabolism of a B-lymphocyte hybridoma grown in batch culture
    • Fitzpatrick L, Jenkins HA, Butler M. Glucose and glutamine metabolism of a B-lymphocyte hybridoma grown in batch culture. Appl Biochem Biotechnol 1993; 43:93.
    • (1993) Appl Biochem Biotechnol , vol.43 , pp. 93
    • Fitzpatrick, L.1    Jenkins, H.A.2    Butler, M.3
  • 15
    • 0028077867 scopus 로고
    • Profile of energy metabolism in a murine hybridoma: Glucose and glutamine utilization
    • Petch D, Butler M. Profile of energy metabolism in a murine hybridoma: glucose and glutamine utilization. J Cell Physiol 1994; 161:71.
    • (1994) J Cell Physiol , vol.161 , pp. 71
    • Petch, D.1    Butler, M.2
  • 16
    • 0030049769 scopus 로고    scopus 로고
    • Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells
    • Neerman J, Wagner R. Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells. J Cell Physiol 1996; 166:152.
    • (1996) J Cell Physiol , vol.166 , pp. 152
    • Neerman, J.1    Wagner, R.2
  • 18
    • 1842297541 scopus 로고    scopus 로고
    • The effect of dissolved oxygen on the metabolic profile of a murine hybridoma grown in serum-free medium in continuous culture
    • Jan DCH, Petch DA, Huzel N, Butler M. The effect of dissolved oxygen on the metabolic profile of a murine hybridoma grown in serum-free medium in continuous culture. Biotechnol Bioeng 1997; 54:153.
    • (1997) Biotechnol Bioeng , vol.54 , pp. 153
    • Jan, D.C.H.1    Petch, D.A.2    Huzel, N.3    Butler, M.4
  • 19
    • 0024416044 scopus 로고
    • The pentose cycle. Rigorous evaluation of limits to the flux from glucose using I4CO2 data, with applications to peripherial ganglia of chicken embryos
    • Larrabee MG. The pentose cycle. Rigorous evaluation of limits to the flux from glucose using I4CO2 data, with applications to peripherial ganglia of chicken embryos. J Biol Chem 1989; 264:15875.
    • (1989) J Biol Chem , vol.264 , pp. 15875
    • Larrabee, M.G.1
  • 20
    • 0028036096 scopus 로고
    • Modelling of isotope distributions and intracellular fluxes in metabolic networks using atom mapping matrices
    • Zupke C, Stephanopoulos G. Modelling of isotope distributions and intracellular fluxes in metabolic networks using atom mapping matrices. Biotechnol Prog 1994; 10:489.
    • (1994) Biotechnol Prog , vol.10 , pp. 489
    • Zupke, C.1    Stephanopoulos, G.2
  • 21
    • 0035922073 scopus 로고    scopus 로고
    • Metabolix-flux analysis of continuously cultured hybridoma cells using 13CO2 mass spectrometry in combination with 13C-lactate nuclear magnetic resonance spectroscopy and metabolite balancing
    • Bonarius HPJ, Özemre A, Timmerarends B, Skrabal P, Tramper J, Schmid G, Heinzle E. Metabolix-flux analysis of continuously cultured hybridoma cells using 13CO2 mass spectrometry in combination with 13C-lactate nuclear magnetic resonance spectroscopy and metabolite balancing. Biotechnol Bioeng 2001; 74:528.
    • (2001) Biotechnol Bioeng , vol.74 , pp. 528
    • Bonarius, H.P.J.1    Özemre, A.2    Timmerarends, B.3    Skrabal, P.4    Tramper, J.5    Schmid, G.6    Heinzle, E.7
  • 22
    • 0015523719 scopus 로고
    • Permeation of glucose by simple and facilitated diffusion by Novikoff rat hepatoma cells in suspension culture and its relationship to glucose metabolism
    • Renner ED, Plagemann PGW, Bernlohr RW. Permeation of glucose by simple and facilitated diffusion by Novikoff rat hepatoma cells in suspension culture and its relationship to glucose metabolism. J Biol Chem 1972; 247:5765.
    • (1972) J Biol Chem , vol.247 , pp. 5765
    • Renner, E.D.1    Plagemann, P.G.W.2    Bernlohr, R.W.3
  • 23
    • 0018386209 scopus 로고
    • Evidence that glutamine, not sugar, is the major energy source for cultivated HeLa cells
    • Reitzer LJ, Wice BM, Kenell D. Evidence that glutamine, not sugar, is the major energy source for cultivated HeLa cells. J Biol Chem 1979; 254:2669.
    • (1979) J Biol Chem , vol.254 , pp. 2669
    • Reitzer, L.J.1    Wice, B.M.2    Kenell, D.3
  • 24
    • 84988106827 scopus 로고
    • A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate and pH
    • Miller WM, Blanch HW, Wilke CR. A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: effect of nutrient concentration, dilution rate and pH. Biotechnol Bioeng 1988; 32:947.
    • (1988) Biotechnol Bioeng , vol.32 , pp. 947
    • Miller, W.M.1    Blanch, H.W.2    Wilke, C.R.3
  • 25
    • 0028306741 scopus 로고
    • Estimation of specific glucose uptake rates in cultures of hybridoma cells
    • Pörtner R, Bohmann A, Lüdemann I, Märkl H. Estimation of specific glucose uptake rates in cultures of hybridoma cells. J Biotechnol 1994; 34:237.
    • (1994) J Biotechnol , vol.34 , pp. 237
    • Pörtner, R.1    Bohmann, A.2    Lüdemann, I.3    Märkl, H.4
  • 26
    • 84996113208 scopus 로고
    • Transient responses of hybridoma cells to nutrient additions in continuous culture: I. Glucose pulse and step changes
    • Miller WM, Wilke CR, Blanch HW. Transient responses of hybridoma cells to nutrient additions in continuous culture: I. Glucose pulse and step changes. Biotechnol Bioeng 1989; 33:477.
    • (1989) Biotechnol Bioeng , vol.33 , pp. 477
    • Miller, W.M.1    Wilke, C.R.2    Blanch, H.W.3
  • 27
    • 0031282223 scopus 로고    scopus 로고
    • Identification of key patterns in the metabolism of hybridoma cells in culture
    • Sanfeliu A, Paredes C, Cairó JJ, Gódia F. Identification of key patterns in the metabolism of hybridoma cells in culture. Enzyme Microb Technol 1997; 21:421.
    • (1997) Enzyme Microb Technol , vol.21 , pp. 421
    • Sanfeliu, A.1    Paredes, C.2    Cairó, J.J.3    Gódia, F.4
  • 28
    • 0022787791 scopus 로고
    • Reduction of waste product excretion via nutrient control: Possible strategies for maximizing product and cell yields on serum in cultures of mammalian cells
    • Glacken MW, Fleischaker RJ, Sinskey AJ. Reduction of waste product excretion via nutrient control: possible strategies for maximizing product and cell yields on serum in cultures of mammalian cells. Biotechnol Bioeng 1986; 28:1376.
    • (1986) Biotechnol Bioeng , vol.28 , pp. 1376
    • Glacken, M.W.1    Fleischaker, R.J.2    Sinskey, A.J.3
  • 32
    • 0035543345 scopus 로고    scopus 로고
    • Analysis of CHO cells metabolic redistribution in a glutamate-based defined medium in continuous culture
    • Altamirano C, Illanes A, Casablancas A, Gámez X, Cairó JJ, Gòdia F. Analysis of CHO cells metabolic redistribution in a glutamate-based defined medium in continuous culture. Biotechnol Prog 2001; 17:1032.
    • (2001) Biotechnol Prog , vol.17 , pp. 1032
    • Altamirano, C.1    Illanes, A.2    Casablancas, A.3    Gámez, X.4    Cairó, J.J.5    Gòdia, F.6
  • 33
    • 0032586148 scopus 로고    scopus 로고
    • Metabolic shifts by nutrient manipulation in continuous cultures of BHK cells
    • Cruz HJ, Moreira JL, Carrondo MJT. Metabolic shifts by nutrient manipulation in continuous cultures of BHK cells. Biotechnol Bioeng 1999; 66:104.
    • (1999) Biotechnol Bioeng , vol.66 , pp. 104
    • Cruz, H.J.1    Moreira, J.L.2    Carrondo, M.J.T.3
  • 34
    • 0000069903 scopus 로고
    • New perspectives on carbohydrate metabolism in tumor cells
    • Baitner R, ed, Boca Raton:CRC Press
    • Eigenbrodt E, Fister P, Reinacher M. New perspectives on carbohydrate metabolism in tumor cells. In: Baitner R, ed. Regulation of Carbohydrate Metabolism. Boca Raton:CRC Press, 1985:141.
    • (1985) Regulation of Carbohydrate Metabolism , pp. 141
    • Eigenbrodt, E.1    Fister, P.2    Reinacher, M.3
  • 35
    • 0343470670 scopus 로고
    • Pathways of intracellular hydrogen transport
    • Boxer GE, Devlin TM. Pathways of intracellular hydrogen transport. Science 1961; 134:1495.
    • (1961) Science , vol.134 , pp. 1495
    • Boxer, G.E.1    Devlin, T.M.2
  • 36
    • 0019755991 scopus 로고
    • Membrane cholesterol, tumorigenesis and the biochemical phenotype of neoplasia
    • Coleman PS, Lavietes BB. Membrane cholesterol, tumorigenesis and the biochemical phenotype of neoplasia. CRC Crit Rev Biochem 1981; 11:341.
    • (1981) CRC Crit Rev Biochem , vol.11 , pp. 341
    • Coleman, P.S.1    Lavietes, B.B.2
  • 37
    • 0018386209 scopus 로고
    • Evidence that glutamine, not sugar is the major source for cultured HeLa cells
    • Reitzer LJ, Wice BM, Kennell D. Evidence that glutamine, not sugar is the major source for cultured HeLa cells. J Biol Chem 1979; 254:2669.
    • (1979) J Biol Chem , vol.254 , pp. 2669
    • Reitzer, L.J.1    Wice, B.M.2    Kennell, D.3
  • 38
    • 0021366190 scopus 로고
    • Glutamine: A major energy source for cultured mammalian cells
    • Zielke HR, Zielke CL, Ozand PT. Glutamine: a major energy source for cultured mammalian cells. Fed Proc 1984; 43:121.
    • (1984) Fed Proc , vol.43 , pp. 121
    • Zielke, H.R.1    Zielke, C.L.2    Ozand, P.T.3
  • 39
    • 0000409606 scopus 로고
    • Spontaneous decomposition of glutamine in cell culture media
    • Trisch GL, Moore GE. Spontaneous decomposition of glutamine in cell culture media. Exp Cell Res 1962; 28:360.
    • (1962) Exp Cell Res , vol.28 , pp. 360
    • Trisch, G.L.1    Moore, G.E.2
  • 40
    • 0034843258 scopus 로고    scopus 로고
    • Recent molecular advances in mammalian glutamine transport
    • Bode BP, Recent molecular advances in mammalian glutamine transport. J Nutr 2001; 131:2475S.
    • (2001) J Nutr , vol.131 , pp. 2475
    • Bode, B.P.1
  • 41
    • 0019332419 scopus 로고
    • The role of microcompartmentation in the regulation of glutamate metabolism by rat kidney mitochondria
    • Schoolwerth AC, LaNoue KF. The role of microcompartmentation in the regulation of glutamate metabolism by rat kidney mitochondria. J Biol Chem 1980; 255:3403.
    • (1980) J Biol Chem , vol.255 , pp. 3403
    • Schoolwerth, A.C.1    LaNoue, K.F.2
  • 42
    • 0002643676 scopus 로고
    • Glutaminolysis in animal cells
    • Morgan J, ed, New York: Plenum Press
    • McKeehnan WL. Glutaminolysis in animal cells. In: Morgan J, ed. Carbohydrate Metabolism in Cultured Cells. New York: Plenum Press, 1986:111.
    • (1986) Carbohydrate Metabolism in Cultured Cells , pp. 111
    • McKeehnan, W.L.1
  • 44
    • 0007205407 scopus 로고
    • The relationship between purines, pyrimidines, nucleosides, and glutamine for fibroblast cell proliferation
    • Engstrom W, Zetterberg A. The relationship between purines, pyrimidines, nucleosides, and glutamine for fibroblast cell proliferation. J Biol Chem 1984; 218:607.
    • (1984) J Biol Chem , vol.218 , pp. 607
    • Engstrom, W.1    Zetterberg, A.2
  • 45
    • 0032486571 scopus 로고    scopus 로고
    • Fluxes and enzyme activities in central metabolism of myeloma cells grown in chemostat culture
    • Vriezen N, van Dijken JP. Fluxes and enzyme activities in central metabolism of myeloma cells grown in chemostat culture. Biotechnol Bioeng 1998; 59:28.
    • (1998) Biotechnol Bioeng , vol.59 , pp. 28
    • Vriezen, N.1    van Dijken, J.P.2
  • 46
    • 0029239589 scopus 로고
    • Intracellular flux analysis in hybridomas using mass balances and in vitro 13C NMR
    • Zupke C, Stephanopoulos G. Intracellular flux analysis in hybridomas using mass balances and in vitro 13C NMR. Biotechnol Bioeng 1995; 45:292.
    • (1995) Biotechnol Bioeng , vol.45 , pp. 292
    • Zupke, C.1    Stephanopoulos, G.2
  • 48
    • 0021894440 scopus 로고
    • Transport of metabolic substrates in renal mitochondria
    • Schoolwerth AC, LaNoue KF. Transport of metabolic substrates in renal mitochondria. Annu Rev Physiol 1985; 47:143.
    • (1985) Annu Rev Physiol , vol.47 , pp. 143
    • Schoolwerth, A.C.1    LaNoue, K.F.2
  • 51
    • 0022345921 scopus 로고
    • Transamination pathways influencing L-glutamine and L-glutamate oxidation by rat enterocyte mitochondria and the subcellular localization of L-alanine aminotransferase and L-aspartate aminotransferase
    • Masola B, Peters TJ, Evered DF. Transamination pathways influencing L-glutamine and L-glutamate oxidation by rat enterocyte mitochondria and the subcellular localization of L-alanine aminotransferase and L-aspartate aminotransferase. Biochim Biophys Acta 1985; 843:137.
    • (1985) Biochim Biophys Acta , vol.843 , pp. 137
    • Masola, B.1    Peters, T.J.2    Evered, D.F.3
  • 52
    • 0019898583 scopus 로고
    • Glycoslysis, glutaminolysis and cell proliferation
    • McKeehan WL. Glycoslysis, glutaminolysis and cell proliferation. Cell Biol Int Rep 1982; 6:635.
    • (1982) Cell Biol Int Rep , vol.6 , pp. 635
    • McKeehan, W.L.1
  • 53
    • 0031984274 scopus 로고    scopus 로고
    • Oxidation of glutamine in HeLa cells: Role and control of truncated TCA cycles in tumour mitochondria
    • Piva TJ, McEvoy-Bowe E. Oxidation of glutamine in HeLa cells: role and control of truncated TCA cycles in tumour mitochondria. J Cell Biochem 1998; 68:213.
    • (1998) J Cell Biochem , vol.68 , pp. 213
    • Piva, T.J.1    McEvoy-Bowe, E.2
  • 54
    • 0021248051 scopus 로고
    • The pathway of glutamate and glutamine oxidation by tumor cell mitochondria: Role of mitochondrial NAD(P)þ-dependent malic enzyme
    • Moreadith RW, Lehninger AL. The pathway of glutamate and glutamine oxidation by tumor cell mitochondria: role of mitochondrial NAD(P)þ-dependent malic enzyme. J Biol Chem 1984; 259:6215.
    • (1984) J Biol Chem , vol.259 , pp. 6215
    • Moreadith, R.W.1    Lehninger, A.L.2
  • 55
    • 0021355202 scopus 로고
    • The oxidation of glutamine and glutamate in relation to anion transport in enterocyte mitochondria
    • Evered DF, Masola B. The oxidation of glutamine and glutamate in relation to anion transport in enterocyte mitochondria. Biochem J 1984; 218:449.
    • (1984) Biochem J , vol.218 , pp. 449
    • Evered, D.F.1    Masola, B.2
  • 56
    • 0026060803 scopus 로고
    • Control and function of the transamination pathways of glutamine oxidation in tumour cells
    • Kovacevic Z, Brkljac O, Bajin K. Control and function of the transamination pathways of glutamine oxidation in tumour cells. Biochem J 1991; 273:271.
    • (1991) Biochem J , vol.273 , pp. 271
    • Kovacevic, Z.1    Brkljac, O.2    Bajin, K.3
  • 57
    • 0002548987 scopus 로고
    • Energetics of glutaminolysis-a theoretical evaluation
    • Spier RE, Griffiths JB, Meignier B, eds, Oxford: Butterworth-Heinemann
    • Häggström L. Energetics of glutaminolysis-a theoretical evaluation. In: Spier RE, Griffiths JB, Meignier B, eds. Production of Biologicals from Animal Cells in Culture. Oxford: Butterworth-Heinemann, 1991:79.
    • (1991) Production of Biologicals from Animal Cells in Culture , pp. 79
    • Häggström, L.1
  • 59
    • 84996094699 scopus 로고
    • The transient responses of hybridoma cells to nutrient additions in continuous culture: II. Glutamine pulse and step changes
    • Miller WM, Wilke CR, Blanch HW. The transient responses of hybridoma cells to nutrient additions in continuous culture: II. Glutamine pulse and step changes. Biotechnol Bioeng 1989; 33:487.
    • (1989) Biotechnol Bioeng , vol.33 , pp. 487
    • Miller, W.M.1    Wilke, C.R.2    Blanch, H.W.3
  • 60
    • 0001464709 scopus 로고
    • The effects of glutamine utilisation and ammonia production on the growth of BHK cells in microcarrier culture
    • Butler M, Spier RE. The effects of glutamine utilisation and ammonia production on the growth of BHK cells in microcarrier culture. J Biotechnol 1984; 1:187.
    • (1984) J Biotechnol , vol.1 , pp. 187
    • Butler, M.1    Spier, R.E.2
  • 61
    • 85134951257 scopus 로고
    • Role of lutamine in hybridoma cell culture: Effects on cell growth, antibody production, and cell metabolism
    • Jeong YH, Wang SS. Role of lutamine in hybridoma cell culture: effects on cell growth, antibody production, and cell metabolism. Enzyme Microb Technol 1995; 77:45.
    • (1995) Enzyme Microb Technol , vol.77 , pp. 45
    • Jeong, Y.H.1    Wang, S.S.2
  • 62
    • 0031554255 scopus 로고    scopus 로고
    • Effects of glutamine supply on growth and metabolism of mammalian cells in chemostat culture
    • Vriezen N, Romein B, Luyben KChAM, van Dijken JP. Effects of glutamine supply on growth and metabolism of mammalian cells in chemostat culture. Biotechnol Bioeng 1997; 54:272.
    • (1997) Biotechnol Bioeng , vol.54 , pp. 272
    • Vriezen, N.1    Romein, B.2    Luyben, K.C.A.M.3    van Dijken, J.P.4
  • 63
    • 0031983480 scopus 로고    scopus 로고
    • Effect of extracellular glutamine concentration on primary and secondary metabolism of a murine hybridoma:An in vivo 13C nuclear magnetic resonance study
    • Mancuso A, Sharfstein ST, Fernandez EJ, Clark DS, Blanch HW. Effect of extracellular glutamine concentration on primary and secondary metabolism of a murine hybridoma:an in vivo 13C nuclear magnetic resonance study. Biotechnol Bioeng 1998; 57:172.
    • (1998) Biotechnol Bioeng , vol.57 , pp. 172
    • Mancuso, A.1    Sharfstein, S.T.2    Fernandez, E.J.3    Clark, D.S.4    Blanch, H.W.5
  • 64
    • 0028500473 scopus 로고
    • Catabolic control of hybridoma cells by glucose and glutamine limited fed batch cultures
    • Ljunggren J, Häggstrom L. Catabolic control of hybridoma cells by glucose and glutamine limited fed batch cultures. Biotechnol Bioeng 1994; 44:808.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 808
    • Ljunggren, J.1    Häggstrom, L.2
  • 65
    • 0028961819 scopus 로고
    • Effects of glucose supply on myeloma growth and metabolism in chemostat culture
    • Meijer JJ, van Dijken JP. Effects of glucose supply on myeloma growth and metabolism in chemostat culture. J Cell Physiol 1995; 162:191.
    • (1995) J Cell Physiol , vol.162 , pp. 191
    • Meijer, J.J.1    van Dijken, J.P.2
  • 66
    • 0024278869 scopus 로고
    • Mathematical description of hybridoma culture kinetics: I. Initial metabolic rates
    • Glacken MW, Adema E, Sinskey AJ. Mathematical description of hybridoma culture kinetics: I. Initial metabolic rates. Biotechnol Bioeng 1988; 32:491.
    • (1988) Biotechnol Bioeng , vol.32 , pp. 491
    • Glacken, M.W.1    Adema, E.2    Sinskey, A.J.3
  • 67
    • 0026592689 scopus 로고
    • Evidence for posttranscriptional stimulation of monoclonal antibody secretion by L-glutamine during slow glutamine growth
    • Flickinger MC, Goebel NK, Bibila T, Boycejacinso S. Evidence for posttranscriptional stimulation of monoclonal antibody secretion by L-glutamine during slow glutamine growth. J Biotechnol 1992; 22:201.
    • (1992) J Biotechnol , vol.22 , pp. 201
    • Flickinger, M.C.1    Goebel, N.K.2    Bibila, T.3    Boycejacinso, S.4
  • 68
    • 0031194880 scopus 로고    scopus 로고
    • Stoichiometry, kinetics and regulation of glucose and amino acid metabolism of recombinant BHK cell line in batch and continuous cultures
    • Linz M, Zeng AP, Wagner R, Deckwer WD. Stoichiometry, kinetics and regulation of glucose and amino acid metabolism of recombinant BHK cell line in batch and continuous cultures. Biotechnol Prog 1997; 13:453.
    • (1997) Biotechnol Prog , vol.13 , pp. 453
    • Linz, M.1    Zeng, A.P.2    Wagner, R.3    Deckwer, W.D.4
  • 69
    • 0027033717 scopus 로고
    • Monitoring hybridoma metabolism in continuous suspension culture at the intracellular level
    • Schmid G, Keller T. Monitoring hybridoma metabolism in continuous suspension culture at the intracellular level. Cytotechnology 1992; 9:217.
    • (1992) Cytotechnology , vol.9 , pp. 217
    • Schmid, G.1    Keller, T.2
  • 70
    • 0034606665 scopus 로고    scopus 로고
    • Multiple steady states with distinct cellular metabolism in continuous culture of mammalian cells
    • Europa AF, Gambhir A, Fu PC, Hu WS. Multiple steady states with distinct cellular metabolism in continuous culture of mammalian cells. Biotechnol Bioeng 2000; 67:25.
    • (2000) Biotechnol Bioeng , vol.67 , pp. 25
    • Europa, A.F.1    Gambhir, A.2    Fu, P.C.3    Hu, W.S.4
  • 72
    • 0016659515 scopus 로고
    • The quantitative requirements of human diploid cells (strain MRC-5) for amino acids, vitamins and serum
    • Lambert K, Pirt SJ. The quantitative requirements of human diploid cells (strain MRC-5) for amino acids, vitamins and serum. J Cell Sci 1975; 17:397.
    • (1975) J Cell Sci , vol.17 , pp. 397
    • Lambert, K.1    Pirt, S.J.2
  • 73
    • 0011210335 scopus 로고
    • Strategies to extend longevity of hybridomas in culture and promote yield of monoclonal antibodies
    • Luan YT, Mutharasan R, Magee WE. Strategies to extend longevity of hybridomas in culture and promote yield of monoclonal antibodies. Biotechnol Lett 1987; 9:691.
    • (1987) Biotechnol Lett , vol.9 , pp. 691
    • Luan, Y.T.1    Mutharasan, R.2    Magee, W.E.3
  • 74
    • 0026219281 scopus 로고
    • Factors controlling cell proliferation and antibody production in mouse hybridoma cells: I. Influence of the amino acid supply
    • Duval D, Demangel C, Munier-Jolain K, Miossec S, Geahel I. Factors controlling cell proliferation and antibody production in mouse hybridoma cells: I. Influence of the amino acid supply. Biotechnol Bioeng 1991; 38:561.
    • (1991) Biotechnol Bioeng , vol.38 , pp. 561
    • Duval, D.1    Demangel, C.2    Munier-Jolain, K.3    Miossec, S.4    Geahel, I.5
  • 75
    • 0025701084 scopus 로고
    • Balanced nutrient fortification enables high density hybridoma cell culture in batch culture
    • Jo EC, Park HJ, Park JM, Kim KH. Balanced nutrient fortification enables high density hybridoma cell culture in batch culture. Biotechnol Bioeng 1990; 36:717.
    • (1990) Biotechnol Bioeng , vol.36 , pp. 717
    • Jo, E.C.1    Park, H.J.2    Park, J.M.3    Kim, K.H.4
  • 76
    • 0032486578 scopus 로고    scopus 로고
    • In hybridoma cell cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of the bcl-2 gene
    • Simpson NH, Singh RP, Perani A, Goldenzon C, Al-Rubeai M. In hybridoma cell cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of the bcl-2 gene. Biotechnol Bioeng 1998; 59:90.
    • (1998) Biotechnol Bioeng , vol.59 , pp. 90
    • Simpson, N.H.1    Singh, R.P.2    Perani, A.3    Goldenzon, C.4    Al-Rubeai, M.5
  • 77
    • 0030937071 scopus 로고    scopus 로고
    • Cell suicide in starving hybridoma culture: Survival-signal effect of some amino acids
    • Franêk K, Srámková K. Cell suicide in starving hybridoma culture: survival-signal effect of some amino acids. Cytotechnology 1997; 23:231.
    • (1997) Cytotechnology , vol.23 , pp. 231
    • Franêk, K.1    Srámková, K.2
  • 78
    • 0000011466 scopus 로고
    • Influence of amino acids on hybridoma cell viability and antibody secretion
    • Geaugey V, Duval D, Geahel I, Marc A, Engasser JM. Influence of amino acids on hybridoma cell viability and antibody secretion. Cytotechnology 1989; 2:119.
    • (1989) Cytotechnology , vol.2 , pp. 119
    • Geaugey, V.1    Duval, D.2    Geahel, I.3    Marc, A.4    Engasser, J.M.5
  • 79
    • 0030088497 scopus 로고    scopus 로고
    • Analysis of nutritional factors and physical conditions affecting growth and monoclonal antibody production of the hybridoma KB-26.5 cell line
    • Sanfeliu A, Cairó JJ, Casas C, Solà C, Gòdia F. Analysis of nutritional factors and physical conditions affecting growth and monoclonal antibody production of the hybridoma KB-26.5 cell line. Biotechnol Prog 1996; 12:209.
    • (1996) Biotechnol Prog , vol.12 , pp. 209
    • Sanfeliu, A.1    Cairó, J.J.2    Casas, C.3    Solà, C.4    Gòdia, F.5
  • 80
    • 0019457724 scopus 로고
    • Amino acids and glucose utilization by different metabolic pathways in ascites-tumour cells
    • Lazo PA. Amino acids and glucose utilization by different metabolic pathways in ascites-tumour cells. Eur J Biochem 1981; 117:19.
    • (1981) Eur J Biochem , vol.117 , pp. 19
    • Lazo, P.A.1
  • 81
    • 0030956481 scopus 로고    scopus 로고
    • Molecular characteristics of mammalian and insect amino acid transporters: Implications for amino acid homeostasis
    • Castagna M, Shayakul Ch, Trotti D, Franca Sacchi V, Harvey WR, Hediger MA. Molecular characteristics of mammalian and insect amino acid transporters: implications for amino acid homeostasis. J Exp Biol 1997; 200:269.
    • (1997) J Exp Biol , vol.200 , pp. 269
    • Castagna, M.1    Ch, S.2    Trotti, D.3    Harvey, W.R.4    Hediger, M.A.5
  • 82
    • 0020998529 scopus 로고
    • Oxygen in human lymphoblastoid cell line cultures and effect of polymers in agitated and aerated cultures
    • Mizrahi A. Oxygen in human lymphoblastoid cell line cultures and effect of polymers in agitated and aerated cultures. Dev Biol Stand 1984; 55:93.
    • (1984) Dev Biol Stand , vol.55 , pp. 93
    • Mizrahi, A.1
  • 85
    • 0023483203 scopus 로고
    • Effects of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture
    • Miller WM, Wilke CR, Blanch HW. Effects of dissolved oxygen concentration on hybridoma growth and metabolism in continuous culture. J Cell Physiol 1987; 132:524.
    • (1987) J Cell Physiol , vol.132 , pp. 524
    • Miller, W.M.1    Wilke, C.R.2    Blanch, H.W.3
  • 86
    • 0025514467 scopus 로고
    • Effects of dissolved oxygen on hybridoma cell growth, metabolism and antibody production kinetics in continuous culture
    • Ozturk SS, Palsson BO. Effects of dissolved oxygen on hybridoma cell growth, metabolism and antibody production kinetics in continuous culture. Biotechnol Prog 1990; 6:437.
    • (1990) Biotechnol Prog , vol.6 , pp. 437
    • Ozturk, S.S.1    Palsson, B.O.2
  • 87
    • 1842297541 scopus 로고    scopus 로고
    • The effect of dissolved oxygen on the metabolic profile of a murine hybridoma grown in serum-free medium in continuous culture
    • Jan DCH, Petch DA, Huzel N, Butler M. The effect of dissolved oxygen on the metabolic profile of a murine hybridoma grown in serum-free medium in continuous culture. Biotechnol Bioeng 1997; 54:153.
    • (1997) Biotechnol Bioeng , vol.54 , pp. 153
    • Jan, D.C.H.1    Petch, D.A.2    Huzel, N.3    Butler, M.4
  • 88
    • 0028790261 scopus 로고
    • Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas
    • Zupke C, Sinskey AJ, Stephanopoulos G. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol 1995; 44:27.
    • (1995) Appl Microbiol Biotechnol , vol.44 , pp. 27
    • Zupke, C.1    Sinskey, A.J.2    Stephanopoulos, G.3
  • 89
    • 0024462705 scopus 로고
    • Growth of mammalian cells at high oxygen concentrations
    • Oiler AR, Buser CW, Tyo MA, Thilly WG. Growth of mammalian cells at high oxygen concentrations. J Cell Sci 1989; 14:43.
    • (1989) J Cell Sci , vol.14 , pp. 43
    • Oiler, A.R.1    Buser, C.W.2    Tyo, M.A.3    Thilly, W.G.4
  • 91
    • 0033527082 scopus 로고    scopus 로고
    • Effects of cell density and temperature on oxygen consumption rate for different mammalian cell lines
    • Jorjani P, Ozturk SS. Effects of cell density and temperature on oxygen consumption rate for different mammalian cell lines. Biotechnol Bioeng 1999; 64:349.
    • (1999) Biotechnol Bioeng , vol.64 , pp. 349
    • Jorjani, P.1    Ozturk, S.S.2
  • 92
    • 85134953759 scopus 로고    scopus 로고
    • Environmental effects on cell physiology and metabolism: Response to elevated pCO2
    • Lindner-Olsson E, Chatzissavidou N, Lüllau E, eds, Dordrecht: Kluwer Academic Publishers
    • Schmelzer AE, Miller WM, Dezengotita VM, Abston LR. Environmental effects on cell physiology and metabolism: response to elevated pCO2. In: Lindner-Olsson E, Chatzissavidou N, Lüllau E, eds. Animal Cell Technology: from Market to Target. Dordrecht: Kluwer Academic Publishers, 2001:121.
    • (2001) Animal Cell Technology: From Market to Target , pp. 121
    • Schmelzer, A.E.1    Miller, W.M.2    Dezengotita, V.M.3    Abston, L.R.4
  • 93
    • 0033589369 scopus 로고    scopus 로고
    • Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO2 or pH
    • Zanghi JA, Schmeltzer AE, Mendoza TP, Knop RH, Miller WM. Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO2 or pH. Biotechnol Bioeng 1999; 65:182.
    • (1999) Biotechnol Bioeng , vol.65 , pp. 182
    • Zanghi, J.A.1    Schmeltzer, A.E.2    Mendoza, T.P.3    Knop, R.H.4    Miller, W.M.5
  • 94
    • 0032442233 scopus 로고    scopus 로고
    • Effects of CO2 and osmolality on hubridoma cells: Growth, metabolism and monoclonal antibody production
    • deZengotita VM, Kimura R, Miller WM. Effects of CO2 and osmolality on hubridoma cells: growth, metabolism and monoclonal antibody production. Cytotechnology 1998; 28:213.
    • (1998) Cytotechnology , vol.28 , pp. 213
    • deZengotita, V.M.1    Kimura, R.2    Miller, W.M.3
  • 96
    • 34247537842 scopus 로고    scopus 로고
    • Solution to the high dissolved CO2 problem in high density perfusion culture of mammalian cells
    • Lindner-Olsson E, Chatzissavidou N, Lüllau E, eds, Dordrecht: Kluwer Academic Publishers
    • Matanguihan R, Sajan E, Zachariou M, Olson C, Michaels J, Thrift J, Konstantinov K. Solution to the high dissolved CO2 problem in high density perfusion culture of mammalian cells. In: Lindner-Olsson E, Chatzissavidou N, Lüllau E, eds. Animal Cell Technology: from Market to Target. Dordrecht: Kluwer Academic Publishers, 2001:18.
    • (2001) Animal Cell Technology: From Market to Target , pp. 18
    • Matanguihan, R.1    Sajan, E.2    Zachariou, M.3    Olson, C.4    Michaels, J.5    Thrift, J.6    Konstantinov, K.7
  • 97
    • 0026816686 scopus 로고
    • Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production
    • Ozturk SS, Riley MR, Palsson BO. Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production. Biotechnol Bioeng 1992; 39:418.
    • (1992) Biotechnol Bioeng , vol.39 , pp. 418
    • Ozturk, S.S.1    Riley, M.R.2    Palsson, B.O.3
  • 98
    • 0027112176 scopus 로고
    • Effects of lactate concentration on hybridoma culture in lactate-controlled fed-batch operation
    • Omasa T, Higashiyama K, Shioya S, Suga K. Effects of lactate concentration on hybridoma culture in lactate-controlled fed-batch operation. Biotechnol Bioeng 1992; 39:556.
    • (1992) Biotechnol Bioeng , vol.39 , pp. 556
    • Omasa, T.1    Higashiyama, K.2    Shioya, S.3    Suga, K.4
  • 100
    • 0031554884 scopus 로고    scopus 로고
    • Fed-batch culture of recombinant NSO myeloma cells with high monoclonal antibody production
    • Zhou W, Chen CC, Buckland BC, Aunins JG. Fed-batch culture of recombinant NSO myeloma cells with high monoclonal antibody production. Biotechnol Bioeng 1997; 55:783.
    • (1997) Biotechnol Bioeng , vol.55 , pp. 783
    • Zhou, W.1    Chen, C.C.2    Buckland, B.C.3    Aunins, J.G.4
  • 101
    • 0034609598 scopus 로고    scopus 로고
    • Phosphate feeding improves highcell- concentration NSO myeloma culture performance for monoclonal antibody production
    • deZengotita VM, Miller WM, Aunins JG, Zhou W. Phosphate feeding improves highcell- concentration NSO myeloma culture performance for monoclonal antibody production. Biotechnol Bioeng 2000; 69:566.
    • (2000) Biotechnol Bioeng , vol.69 , pp. 566
    • deZengotita, V.M.1    Miller, W.M.2    Aunins, J.G.3    Zhou, W.4
  • 102
    • 0023763120 scopus 로고
    • Catabolic control of mammalian cell culture
    • Glacken MW. Catabolic control of mammalian cell culture. Bio=Technology 1988; 6:1041.
    • (1988) Bio=Technology , vol.6 , pp. 1041
    • Glacken, M.W.1
  • 103
    • 0025435131 scopus 로고
    • Effect of ammonium ion and extracellular pH on hybridoma cell metabolism and antibody production
    • McQueen A, Bailey JE. Effect of ammonium ion and extracellular pH on hybridoma cell metabolism and antibody production. Biotechnol Bioeng 1990; 35:1067.
    • (1990) Biotechnol Bioeng , vol.35 , pp. 1067
    • McQueen, A.1    Bailey, J.E.2
  • 104
    • 0025465312 scopus 로고
    • Growth behavior of Chinese hamster ovary cells in a compact loop reactor. 2. Effects of medium components and waste products
    • Kurano N, Leist C, Messi F, Kurano S, Fiechter A. Growth behavior of Chinese hamster ovary cells in a compact loop reactor. 2. Effects of medium components and waste products. J Biotechnol 1990; 15:113.
    • (1990) J Biotechnol , vol.15 , pp. 113
    • Kurano, N.1    Leist, C.2    Messi, F.3    Kurano, S.4    Fiechter, A.5
  • 105
    • 0028452886 scopus 로고
    • Biochemistry of growth inhibition by ammonium ions in mammalian cells
    • Ryll T, Valley U, Wagner R. Biochemistry of growth inhibition by ammonium ions in mammalian cells. Biotechnol Bioeng 1994; 44:184.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 184
    • Ryll, T.1    Valley, U.2    Wagner, R.3
  • 106
    • 0026196692 scopus 로고
    • Growth inhibition in animal cell culture. The effect of lactate and ammonia
    • Hassell T, Gleave S, Butler M. Growth inhibition in animal cell culture. The effect of lactate and ammonia. Appl Biochem Biotechnol 1991; 30:29.
    • (1991) Appl Biochem Biotechnol , vol.30 , pp. 29
    • Hassell, T.1    Gleave, S.2    Butler, M.3
  • 107
    • 0034690723 scopus 로고    scopus 로고
    • Effects of ammonia on CHO cell growth, erythropoietin production, and glycosilation
    • Yang M, Butler M. Effects of ammonia on CHO cell growth, erythropoietin production, and glycosilation. Biotechnol Bioeng 2000; 68:370.
    • (2000) Biotechnol Bioeng , vol.68 , pp. 370
    • Yang, M.1    Butler, M.2
  • 108
    • 0027952407 scopus 로고
    • Influence of ammonium on growth, metabolism and productivity of a continuous suspension Chinese hamster ovary cell culture
    • Hansen HA, Emborg C. Influence of ammonium on growth, metabolism and productivity of a continuous suspension Chinese hamster ovary cell culture. Biotechnol Prog 1994; 10:121.
    • (1994) Biotechnol Prog , vol.10 , pp. 121
    • Hansen, H.A.1    Emborg, C.2
  • 109
    • 34250092706 scopus 로고
    • Transient response of hybridoma cells to lactate and ammonia pulse and step changes in continuous culture
    • Miller WM, Wilke CR, Blanch HW. Transient response of hybridoma cells to lactate and ammonia pulse and step changes in continuous culture. Bioprocess Eng 1988; 35:113.
    • (1988) Bioprocess Eng , vol.35 , pp. 113
    • Miller, W.M.1    Wilke, C.R.2    Blanch, H.W.3
  • 111
    • 0026018555 scopus 로고
    • Growth inhibition of hybridoma cells by ammonium ion: Correlation with effects on intracellular pH
    • McQueen A, Bailey JE. Growth inhibition of hybridoma cells by ammonium ion: correlation with effects on intracellular pH. Bioprocess Eng 1991; 6:49.
    • (1991) Bioprocess Eng , vol.6 , pp. 49
    • McQueen, A.1    Bailey, J.E.2
  • 112
    • 0029937194 scopus 로고    scopus 로고
    • The importance of ammonia in mammalian cell culture
    • Schneider YJ, Marison IW, Stockar U. The importance of ammonia in mammalian cell culture. J Biotechnol 1996; 46:161.
    • (1996) J Biotechnol , vol.46 , pp. 161
    • Schneider, Y.J.1    Marison, I.W.2    Stockar, U.3
  • 113
    • 0029636676 scopus 로고
    • The effect of ammonia on the O-linked glycosylation of granulocyte colony-stimulating factor produced by Chinese hamster ovary cells
    • Andersen DC, Goochee CF. The effect of ammonia on the O-linked glycosylation of granulocyte colony-stimulating factor produced by Chinese hamster ovary cells. Biotechnol Bioeng 1995; 47:96.
    • (1995) Biotechnol Bioeng , vol.47 , pp. 96
    • Andersen, D.C.1    Goochee, C.F.2
  • 114
    • 0028393399 scopus 로고
    • Ammonia affects the glycosylation pattern of recombinant mouse placental lactogen-I by Chinese hamster ovary cells in a pHdependent manner
    • Borys MC, Linzer DIH, Papoutsakis ET. Ammonia affects the glycosylation pattern of recombinant mouse placental lactogen-I by Chinese hamster ovary cells in a pHdependent manner. Biotechnol Bioeng 1994; 43:505.
    • (1994) Biotechnol Bioeng , vol.43 , pp. 505
    • Borys, M.C.1    Linzer, D.I.H.2    Papoutsakis, E.T.3
  • 115
    • 0022530474 scopus 로고
    • Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion
    • Thorens B, Vassalli P. Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion. Nature 1986; 321:618.
    • (1986) Nature , vol.321 , pp. 618
    • Thorens, B.1    Vassalli, P.2
  • 116
    • 0032485239 scopus 로고    scopus 로고
    • Ammonium ion and glucosamine dependent increases of oligosaccharide complexity in recombinant glycoproteins secreted from cultivated BHK-21 cells
    • Gawlitzek M, Valley U, Wagner R. Ammonium ion and glucosamine dependent increases of oligosaccharide complexity in recombinant glycoproteins secreted from cultivated BHK-21 cells. Biotechnol Bioeng 1998; 57:518.
    • (1998) Biotechnol Bioeng , vol.57 , pp. 518
    • Gawlitzek, M.1    Valley, U.2    Wagner, R.3
  • 117
    • 0026213308 scopus 로고
    • Growth limitation in hybridoma cell cultures: The role of inhibitory or toxic metabolites
    • Ronning OW, Schartum M, Winsnes A, Lindberg G. Growth limitation in hybridoma cell cultures: the role of inhibitory or toxic metabolites. Cytotechnology 1991; 7:15.
    • (1991) Cytotechnology , vol.7 , pp. 15
    • Ronning, O.W.1    Schartum, M.2    Winsnes, A.3    Lindberg, G.4
  • 118
    • 0029104088 scopus 로고
    • In pursuit of the optimal fed-batch process for monoclonal antibody production
    • Bibila TA, Robinson DK. In pursuit of the optimal fed-batch process for monoclonal antibody production. Biotechnol Prog 1995; 11:1.
    • (1995) Biotechnol Prog , vol.11 , pp. 1
    • Bibila, T.A.1    Robinson, D.K.2
  • 119
    • 0031554884 scopus 로고    scopus 로고
    • Fed-batch culture of recombinant NSO myeloma cells with high monoclonal antibody production
    • Zhou W, Chen CC, Buckland B, Aunins J. Fed-batch culture of recombinant NSO myeloma cells with high monoclonal antibody production. Biotechnol Bioeng 1997; 55:783.
    • (1997) Biotechnol Bioeng , vol.55 , pp. 783
    • Zhou, W.1    Chen, C.C.2    Buckland, B.3    Aunins, J.4
  • 120
    • 9444286985 scopus 로고    scopus 로고
    • High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor
    • Xie L, Wang DIC. High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor. Biotechnol Bioeng 1996; 51:725.
    • (1996) Biotechnol Bioeng , vol.51 , pp. 725
    • Xie, L.1    Wang, D.I.C.2
  • 121
    • 0034607161 scopus 로고    scopus 로고
    • A high yielding, generic fed-batch cell culture process for production of recombinant antibodies
    • Sauer PW, Burky JE, Wesson MC, Sternard LQ. A high yielding, generic fed-batch cell culture process for production of recombinant antibodies. Biotechnol Bioeng 2000; 67:585.
    • (2000) Biotechnol Bioeng , vol.67 , pp. 585
    • Sauer, P.W.1    Burky, J.E.2    Wesson, M.C.3    Sternard, L.Q.4
  • 122
    • 10144250933 scopus 로고    scopus 로고
    • Monitoring and control of the physiological state of cell cultures
    • Konstantinov KB. Monitoring and control of the physiological state of cell cultures. Biotechnol Bioeng 1996; 52:271.
    • (1996) Biotechnol Bioeng , vol.52 , pp. 271
    • Konstantinov, K.B.1
  • 123
    • 85134993406 scopus 로고    scopus 로고
    • Engineering challenges in high density bioreactors
    • Ozturk SS. Engineering challenges in high density bioreactors. Cytotechnology 1999; 64:349.
    • (1999) Cytotechnology , vol.64 , pp. 349
    • Ozturk, S.S.1
  • 124
    • 0027942360 scopus 로고
    • Glutamine-based dipeptides are utilized in mammalian cell culture by extracellular hydrolysis catalyzed by a specific peptidase
    • Christie A, Butler M. Glutamine-based dipeptides are utilized in mammalian cell culture by extracellular hydrolysis catalyzed by a specific peptidase. J Biotechnol 1994; 37:277.
    • (1994) J Biotechnol , vol.37 , pp. 277
    • Christie, A.1    Butler, M.2
  • 125
    • 0343443442 scopus 로고
    • Growth and metabolism of recombinant CHO cell-lines in serum-free medium containing derivatives of glutamine
    • Spier RE, Griffiths JB, Macdonald C, eds, Oxford: Butterworth-Heinemann
    • Holmlund AC, Chatzisavido N, Bell SL, Lindner-Olsson E. Growth and metabolism of recombinant CHO cell-lines in serum-free medium containing derivatives of glutamine. In: Spier RE, Griffiths JB, Macdonald C, eds. Animal Cell Technology: Developments, Processes and Products. Oxford: Butterworth-Heinemann, 1992:128.
    • (1992) Animal Cell Technology: Developments, Processes and Products , pp. 128
    • Holmlund, A.C.1    Chatzisavido, N.2    Bell, S.L.3    Lindner-Olsson, E.4
  • 126
    • 0025340874 scopus 로고
    • Adaptation to non-ammoniagenic medium and selective substrate feeding lead to enhanced yields in animal cell cultures
    • Hassell T, Butler M. Adaptation to non-ammoniagenic medium and selective substrate feeding lead to enhanced yields in animal cell cultures. J Cell Sci 1990; 96:501.
    • (1990) J Cell Sci , vol.96 , pp. 501
    • Hassell, T.1    Butler, M.2
  • 127
    • 0033527072 scopus 로고    scopus 로고
    • The adaptation of BHK cells to a non-ammoniagenic glutamatebased culture medium
    • Christie A, Butler M. The adaptation of BHK cells to a non-ammoniagenic glutamatebased culture medium. Biotechnol Bioeng 1999; 64:298.
    • (1999) Biotechnol Bioeng , vol.64 , pp. 298
    • Christie, A.1    Butler, M.2
  • 128
    • 0007563632 scopus 로고
    • Growth and metabolism of human tumor kidney cells on galactose and glucose
    • Wagner A, Marc A, Engasser JM, Einsele A. Growth and metabolism of human tumor kidney cells on galactose and glucose. Cytotechnology 1991; 7:7.
    • (1991) Cytotechnology , vol.7 , pp. 7
    • Wagner, A.1    Marc, A.2    Engasser, J.M.3    Einsele, A.4
  • 129
    • 0030446771 scopus 로고    scopus 로고
    • Carbohydrate and amino acid metabolism during batch culture of a human lymphoblastoid cell line BTSN6
    • Marquis CP, Barford JP, Harbour C, Fletcher A. Carbohydrate and amino acid metabolism during batch culture of a human lymphoblastoid cell line BTSN6. Cytotechnology 1996; 21:121.
    • (1996) Cytotechnology , vol.21 , pp. 121
    • Marquis, C.P.1    Barford, J.P.2    Harbour, C.3    Fletcher, A.4
  • 130
    • 0033952514 scopus 로고    scopus 로고
    • Improvement of CHO cell culture medium formulation: Simultaneous substitution of glucose and glutamine
    • Altamirano C, Paredes C, Cairò JJ, Godia F. Improvement of CHO cell culture medium formulation: simultaneous substitution of glucose and glutamine. Biotechnol Prog 2000; 16:69.
    • (2000) Biotechnol Prog , vol.16 , pp. 69
    • Altamirano, C.1    Paredes, C.2    Cairò, J.J.3    Godia, F.4
  • 131
    • 0025866296 scopus 로고
    • Network rigidity and metabolic engineering in metabolite overproduction
    • Stephanopoulos G, Valllino JJ. Network rigidity and metabolic engineering in metabolite overproduction. Science 1991; 252:1675.
    • (1991) Science , vol.252 , pp. 1675
    • Stephanopoulos, G.1    Valllino, J.J.2
  • 132
    • 0032937141 scopus 로고    scopus 로고
    • Modification of glucose and glutamine metabolism in hybridoma cells through metabolic engineering
    • Paredes C, Prats E, Cairò JJ, Azorin F, Cornudella LI, Gódia F. Modification of glucose and glutamine metabolism in hybridoma cells through metabolic engineering. Cytotechnology 1999; 30:85.
    • (1999) Cytotechnology , vol.30 , pp. 85
    • Paredes, C.1    Prats, E.2    Cairò, J.J.3    Azorin, F.4    Cornudella, L.I.5    Gódia, F.6
  • 134
    • 0035808169 scopus 로고    scopus 로고
    • Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production
    • Chen K, Liu Q, Xie L, Sharp PA, Wang DIC. Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production. Biotechnol Bioeng 2001; 72:55.
    • (2001) Biotechnol Bioeng , vol.72 , pp. 55
    • Chen, K.1    Liu, Q.2    Xie, L.3    Sharp, P.A.4    Wang, D.I.C.5
  • 135
    • 0033385223 scopus 로고    scopus 로고
    • Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmatic pyruvate carboxylase reaction
    • Irani N, Wirth M, van den Heuvel J, Wagner R. Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmatic pyruvate carboxylase reaction. Biotechnol Bioeng 1999; 66:238.
    • (1999) Biotechnol Bioeng , vol.66 , pp. 238
    • Irani, N.1    Wirth, M.2    van den Heuvel, J.3    Wagner, R.4
  • 138
    • 0029059493 scopus 로고
    • High viable cell concentration fed-batch cultures of hybridoma cells through on-line nutrient feeding
    • Zhou W, Rehm J, Hu WSh. High viable cell concentration fed-batch cultures of hybridoma cells through on-line nutrient feeding. Biotechnol Bioeng 1995; 46:579
    • (1995) Biotechnol Bioeng , vol.46 , pp. 579
    • Zhou, W.1    Rehm, J.2    Wsh, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.