Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 7, 2009, Pages 2423-2428

  Metz, Alexia E ^a,b   Yau, Hau Jie ^a   Centeno, Maria Virginia ^a   Apkarian, A Vania ^a   Martina, Marco ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF TOLEDO   (United States)

Author keywords

AMPA; Dendrite; mPFC; NMDA; Spine

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITIC SPINE; NERVE CELL PLASTICITY; NEUROPATHIC PAIN; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SENSORY NERVE CONDUCTION; SENSORY STIMULATION; SPINE INJURY;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CEREBRAL CORTEX; DENDRITES; ELECTROPHYSIOLOGY; NEURALGIA; NEURONS; PAIN; PAIN THRESHOLD; PATCH-CLAMP TECHNIQUES; PREFRONTAL CORTEX; RATS;

ANIMALIA; RATTUS;

EID: 60549088106     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0809897106     Document Type: Article

References (42)

1. Gusnard DA, Akbudak E, Shulman GL, Raichle ME (2001) Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci USA 98:4259-4264.
2. Phelps EA, Delgado MR, Nearing KI, LeDoux JE (2004) Extinction learning in humans: role of the amygdala and vmPFC. Neuron 43:897-905.
3. Lorenz J, et al. (2002) A unique representation of heat allodynia in the human brain. Neuron 35:383-393.
4. Rainville P, Duncan GH, Price DD, Carrier B, Bushnell MC (1997) Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 277:968-971.
5. Wager TD, et al. (2004) Placebo-induced changes in FMRI in the anticipation and experience of pain. Science 303:1162-1167.
6. Porro CA, et al. (2002) Does anticipation of pain affect cortical nociceptive systems? J Neurosci 22:3206-3214.
7. Baliki MN, et al. (2006) Chronic pain and the emotional brain: Specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain. J Neurosci 26:12165-12173.
8. Schweinhardt P, et al. (2008) Investigation into the neural correlates of emotional augmentation of clinical pain. Neuroimage 40:759-766.
9. Apkarian AV, et al. (2004) Chronic pain patients are impaired on an emotional decision-making task. Pain 108:129-136.
10. Apkarian AV, et al. (2004) Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci 24:10410-10415.
11. Kuchinad A, et al. (2007) Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain? J Neurosci 27:4004-4007.
12. Fuchs PN, Balinsky M, Melzack R (1996) Electrical stimulation of the cingulum bundle and surrounding cortical tissue reduces formalin-test pain in the rat. Brain Res 743:116-123.
13. Calejesan AA, Kim SJ, Zhuo M (2000) Descending facilitatory modulation of a behavioral nociceptive response by stimulation in the adult rat anterior cingulate cortex. Eur J Pain 4:83-96.
14. Wei F, et al. (2001) Genetic enhancement of inflammatory pain by forebrain NR2B overexpression. Nat Neurosci 4:164-169.
15. Wu LJ, et al. (2005) Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci 25:11107-11116.
16. Hood WF, Compton RP, Monahan JB (1989) D-cycloserine: A ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics. Neurosci Lett 98:91-95.
17. Millecamps M, et al. (2007) D-cycloserine reduces neuropathic pain behavior through limbic NMDA-mediated circuitry. Pain 132:108-123.
18. Vertes RP (2006) Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat. Neuroscience 142:1-20.
19. Sholl DA (1953), Dendritic organization in the neurons of the visual and motor cortices of the cat. J Anat 87:387-406.
20. Abbadie C, Trafton J, Liu H, Mantyh PW, Basbaum AI (1997) Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation. J Neurosci 17:8049-8060.
21. Goff JR, Burkey AR, Goff DJ, Jasmin L (1998) Reorganization of the spinal dorsal horn in models of chronic pain: Correlation with behaviour. Neuroscience 82:559-574.
22. Schwei MJ, et al. (1999) Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain. J Neurosci 19:10886-10897.
23. Basbaum AI (1999) Spinal mechanisms of acute and persistent pain. Reg Anesth Pain Med 24:59-67.
24. Maihöfner C, Handwerker HO, Neundörfer B, Birklein F (2003) Patterns of cortical reorganization in complex regional pain syndrome. Neurology 61:1707-1715.
25. Walton ME, Bannerman DM, Rushworth MF (2002) The role of rat medial frontal cortex in effort-based decision making. J Neurosci 22:10996-11003.
26. Saxe R (2006) Uniquely human social cognition. Curr Opin Neurobiol 16:235-239.
27. Shepherd GM, Svoboda K (2005) Laminar and columnar organization of ascending excitatory projections to layer 2/3 pyramidal neurons in rat barrel cortex. J Neurosci 25:5670-5679.
28. Larkum ME, Waters J, Sakmann B, Helmchen F (2007) Dendritic spikes in apical dendrites of neocortical layer 2/3 pyramidal neurons. J Neurosci 27:8999-9008.
29. Weiler N, Wood L, Yu J, Solla SA, Shepherd GM (2008) Top-down laminar organization of the excitatory network in motor cortex. Nat Neurosci 11:360-366.
30. Maren S, Quirk GJ (2004) Neuronal signalling of fear memory. Nat Rev Neurosci 5:844-852.
31. Bechara A, Damasio H, Damasio AR, Lee GP (1999) Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. J Neurosci 19:5473-5481.
32. Bacon SJ, Headlam AJ, Gabbott PL, Smith AD (1996) Amygdala input to medial prefrontal cortex (mPFC) in the rat: A light and electron microscope study. Brain Res 720:211-219.
33. Wood PB, et al. (2007) Fibromyalgia patients show an abnormal dopamine response to pain. Eur J Neurosci 25:3576-3582.
34. Hoover WB, Vertes RP (2007) Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat. Brain Struct Funct 212:149-179.
35. Zeng D, Stuesse SL (1991) Morphological heterogeneity within the cingulate cortex in rat: a horseradish peroxidase transport study. Brain Res 565:290-300.
36. Aloisi AM, Zimmermann M, Herdegen T (1997) Sex-dependent effects of formalin and restraint on c-Fos expression in the septum and hippocampus of the rat. Neuroscience 81:951-958.
37. Moser MB, Moser EI (1998) Functional differentiation in the hippocampus. Hippocampus 8:608-619.
38. Shapiro ML, Eichenbaum H (1999) Hippocampus as a memory map: Synaptic plasticity and memory encoding by hippocampal neurons. Hippocampus 9:365-384.
39. Zimmermann M (2001) Pathobiology of neuropathic pain. Eur J Pharmacol 429:23-37.
40. Ishikawa A, Ambroggi F, Nicola SM, Fields HL (2008) Dorsomedial prefrontal cortex contribution to behavioral and nucleus accumbens neuronal responses to incentive cues. J Neurosci 28:5088-5098.
41. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53:55-63.
42. Paxinos G, Watson C (1998) The Rat Brain in Stereotaxic Coordinates (Academic, San Diego).