A clonal cell line (BME-UV1) as a possible model to study bovine mammary epithelial metabolism: metabolism and cytotoxicity of aflatoxin B1

Toxicon

Volumn 53, Issue 4, 2009, Pages 400-408

  Caruso, M ^a   Mariotti, A ^b   Zizzadoro, C ^a   Zaghini, A ^b   Ormas, P ^a   Altafini, A ^b   Belloli, C ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Aflatoxin B1; Aflatoxin M1; Bovine; Mammary epithelial cells; Metabolism; Milk

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AFLATOXIN B1; NEUTRAL RED;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; BREAST EPITHELIUM; CATALYSIS; CELL LINE; CELL METABOLISM; CELL VIABILITY; CONCENTRATION (PARAMETERS); CYTOTOXICITY; ENZYME METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MAMMARY GLAND; METABOLITE; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; TIME;

AFLATOXIN B1; AFLATOXIN M1; ANIMALS; CATTLE; CELL LINE; EPITHELIAL CELLS; FEMALE; MAMMARY GLANDS, ANIMAL;

ANIMALIA; BOVINAE;

EID: 60449120484     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2008.12.023     Document Type: Article

References (25)

1. Baldi A., Losio M.N., Cheli F., Rebucci R., Sangalli L., Fusi E., Bertasi B., Pavoni E., Carli S., and Politis I. Evaluation of the protective effects of alpha-tocopherol and retinol against ochratoxin A cytotoxicity. Br. J. Nutr 91 4 (2004) 507-512
2. Barbiroli A., Bonomi F., Benedetti S., Mannino S., Monti L., Cattaneo T., and Iametti S. Binding of aflatoxin M1 to different protein fractions in ovine and caprine milk. J. Dairy Sci. 90 2 (2007) 532-540
3. Borenfreund E., and Puerner J.A. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol. Lett. 24 2-3 (1985) 119-124
4. Caloni F., Stammati A., Frigge G., and De Angelis I. Aflatoxin M1 absorption and cytotoxicity on human intestinal in vitro model. Toxicon 47 4 (2006) 409-415
5. Caruso M., Belloli C., Zaghini A., and Ormas P. Investigation on the metabolic activity of a bovine mammary epithelial cell line (BME-UV1). Vet. Res. Commun 32 Supp.1 (2008) S259-S262
6. CVMP (Committee for Veterinary Medicinal Products), 1998. Guidelines on Validation of Analytical Procedures: Methodology. CVMP/VICH/591/98-Final.
7. Hussein H.S., and Brasel J.M. Toxicity, metabolism and impact of mycotoxins on humans and animals. Toxicology 167 2 (2001) 101-134
8. Kolek O., Gajkowska B., Godlewski M.M., and Motyl T. Antiproliferative and apoptotic effect of TGF-beta 1 in bovine mammary epithelial BME-UV1 cells. Comp. Biochem. Physiol. C Toxicol. Pharmacol 134 4 (2003) 417-430
9. 1. J. Agric. Food Chem. 46 (1998) 2707-2713
10. Kuilman M.E., Maas R.F., and Fink-Gremmels J. Cytochrome P450-mediated metabolism and cytotoxicity of aflatoxin B(1) in bovine hepatocytes. Toxicol. In Vitro 14 (2000) 321-327
11. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
12. Matitashvili E., Bramley A.J., and Zavizion B. An in vitro approach to ruminant mammary gland biology. Biotechnol. Adv 15 1 (1997) 17-41
13. McLean M., and Dutton M.F. Cellular interactions and metabolism of aflatoxin: an update. Pharmacol. Ther 65 2 (1995) 163-192
14. McManaman J.L., and Neville M.C. Mammary physiology and milk secretion. Adv. Drug Deliv. Rev. 55 5 (2003) 629-641
15. Neal G.E. Genetic implications in the metabolism and toxicity of mycotoxins. Toxicol. Lett. 82-83 (1995) 861-867
16. Neal G.E., Eaton D.L., Judah D.J., and Verma A. Metabolism and toxicity of aflatoxins M1 and B1 in human-derived in vitro systems. Toxicol. Appl. Pharmacol 151 1 (1998) 152-158
17. Pavek P., and Dvorak Z. Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues. Curr. Drug Metab 9 2 (2008) 129-143
18. Quesnell R.R., Erickson J., and Schultz B.D. Apical electrolyte concentration modulates barrier function and tight junction protein localization in bovine mammary epithelium. Am. J. Physiol. Cell Physiol 292 1 (2007) C305-C318
19. Schmidt C.R., Carlin R.W., and Sargeant J.M. Neurotransmitter-stimulated ion transport across cultured bovine mammary epithelial cell monolayers. J. Dairy Sci. 84 12 (2001) 2622-2631 B.D.
20. The EFSA (European Food Safety Authority) Journal, 2004. Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to aflatoxin B1 as undesirable substance in animal feed, vol. 39, pp. 1-27.
21. Veldman A., Meijst J.A.C., Borggreve G.J., and Heeres-Van der Tol J.J. Carry-over of aflatoxins from cows' food to milk. Anim. Prod 55 (1992) 163-168
22. Williams J.A., and Phillips D.H. Mammary expression of xenobiotic metabolizing enzymes and their potential role in breast cancer. Cancer Res. 60 17 (2000) 4667-4677
23. Zarzynska J., and Motyl T. Dissimilar effects of LY 294002 and PD 098059 in IGF-I-mediated inhibition of TGF-beta1 expression and apoptosis in bovine mammary epithelial cells. J. Physiol. Pharmacol 56 Suppl. 3 (2005) 181-193
24. Zavizion B., van Duffelen M., Schaeffer W., and Politis I. Establishment and characterization of a bovine mammary epithelial cell line with unique properties. In Vitro Cell Dev. Biol. Anim 32 3 (1996) 138-148
25. Zavizion B., White J.H., and Bramley A.J. Cell cycle-dependent fluctuation of urokinase-type plasminogen activator, its receptor, and inhibitors in cultured bovine mammary epithelial and myoepithelial cells. Biochim. Biophys. Acta 1403 3 (1998) 141-150