The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells

Gynecologic Oncology

Volumn 112, Issue 3, 2009, Pages 623-630

  McLean, Karen ^a   VanDeVen, Natalie A ^a   Sorenson, Dorothy R ^b   Daudi, Sayeema ^a   Liu, J Rebecca ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Apoptosis; Autophagy; Endoplasmic reticulum stress response; Ovarian cancer; Protease inhibitor; Saquinavir

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CASPASE; CISPLATIN; GLUCOSE REGULATED PROTEIN 78; GREEN FLUORESCENT PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1; PROTEINASE INHIBITOR; REGULATOR PROTEIN; SAQUINAVIR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER CELL CULTURE; CELL DEATH; CELL GROWTH; CELL LINE; CELL STRUCTURE; CELL VIABILITY; CHEMOSENSITIVITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; LIGHT CHAIN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY;

ADENOSINE TRIPHOSPHATE; AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; AUTOPHAGY; CASPASE 9; CELL LINE, TUMOR; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENDOPLASMIC RETICULUM; FEMALE; HIV PROTEASE INHIBITORS; HUMANS; OVARIAN NEOPLASMS; SAQUINAVIR;

EID: 60449091833     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2008.11.028     Document Type: Article

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