Interstitial collagenase is a brownian ratchet driven by proteolysis of collagen

Science

Volumn 306, Issue 5693, 2004, Pages 108-111

  Saffarian, Saveez ^a   Collier, Ivan E ^a   Marmer, Barry L ^a   Elson, Elliot L ^a   Goldberg, Gregory ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; BROWNIAN MOVEMENT; CELLS; DIFFUSION; HYDROLYSIS; PROTEINS;

ACTIVATED COLLAGENASE; ADENOSINE TRIPHOSPHATE (ATP) HYDROLYSIS; ENZYME INACTIVATION;

ENZYME KINETICS;

ADENOSINE TRIPHOSPHATASE; COLLAGEN FIBRIL; INTERSTITIAL COLLAGENASE; ADENOSINE TRIPHOSPHATE; COLLAGEN; MOLECULAR MOTOR; RECOMBINANT PROTEIN;

BIOLOGY;

AMINO ACID SUBSTITUTION; ARTICLE; ENZYME INACTIVATION; ENZYME KINETICS; MONTE CARLO METHOD; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN HYDROLYSIS; ANIMAL; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DIFFUSION; FLUORESCENCE; FLUORESCENCE MICROSCOPY; GENETICS; HUMAN; HYDROLYSIS; MATHEMATICS; METABOLISM; POINT MUTATION; PROTEIN TRANSPORT; RAT;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; ANIMALS; COLLAGEN; COMPUTER SIMULATION; DIFFUSION; FLUORESCENCE; HUMANS; HYDROLYSIS; MATHEMATICS; MATRIX METALLOPROTEINASE 1; MICROSCOPY, FLUORESCENCE; MODELS, CHEMICAL; MOLECULAR MOTOR PROTEINS; MONTE CARLO METHOD; POINT MUTATION; PROTEIN TRANSPORT; RATS; RECOMBINANT PROTEINS;

EID: 6044274345     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1099179     Document Type: Article

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32. The authors would like to thank M. S. Conrady for the use of the superconducting magnet. We also thank H. Qian and A. Elsen for reading the manuscript and helpful discussions. This work was supported in part by NIH grants GM-3883B to E.L.E., AR4061B, AR39472 to G.I.G. and Washington University-Pfizer Inc. agreement.