Evaluation of the neuroprotective efficacy of newly developed oximes (K206, K269) and currently available oximes (Obidoxime, HI-6) in cyclosarin-poisoned rats

Basic and Clinical Pharmacology and Toxicology

Volumn 104, Issue 3, 2009, Pages 228-235

  Kassa, Jiri ^a,b   Karasova, Jana Zdarova ^b   Bajgar, Jiri ^b   Tesarova, Sandra ^d   Kuca, Kamil ^c   Musilek, Kamil ^b  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b Department of Toxicology ^*  (Czech Republic)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

^d 7th Field Hospital   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ANTIDOTE; ATROPINE; CYCLOSARIN; K 269; OBIDOXIME; OXIME; TIPINDOLE METHIODIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; FUNCTIONAL OBSERVATIONAL BATTERY PROCEDURE; INTOXICATION; MALE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OBSERVATION; PRIORITY JOURNAL; RAT; WISTAR RAT;

ANIMALS; ANTIDOTES; ATROPINE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE REACTIVATORS; DRUG THERAPY, COMBINATION; MALE; MUSCARINIC ANTAGONISTS; NEUROPROTECTIVE AGENTS; OBIDOXIME CHLORIDE; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; PYRIDINIUM COMPOUNDS; RATS; RATS, WISTAR;

RATTUS;

EID: 60349129821     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2008.00352.x     Document Type: Article

References (29)

1. Marrs TC. Organophosphate poisoning. Pharmacol Ther 1993 58 : 51 66.
2. Lotti M. Organophosphorus compounds. In : Spencer PS, Schaumburg HH (eds). Experimental and Clinical Neurotoxicology. Oxford University Press, New York, 2000 898 925.
3. Bajgar J. Organophosphate/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment. Adv Clin Chem 2004 38 : 151 216.
4. Taylor P. Anticholinesterase agents. In : Hardman JG, Limbird LE (eds). The Pharmacological Basis of Therapeutics. McGraw Hill, New York, 1996 161 76.
5. Kassa J. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol Clin Toxicol 2002 40 : 803 16.
6. Shih TM. Comparison of several oximes on reactivation of soman-inhibited blood, brain and tissue cholinesterase activity. Arch Toxicol 1993 67 : 637 46.
7. Worek F, Backer M, Thiermann H, Szinicz L, Mast U, Klimmek R et al. Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning. Hum Exp Toxicol 1997 16 : 466 72.
8. Clement JG. Efficacy of various oximes against GF (cyclohexyl methylphosphono-fluoridate) poisoning in mice. Arch Toxicol 1992 66 : 143 4.
9. Lundy PM, Hansen AS, Hand BT, Boulet CA. Comparison of several oximes against poisoning by soman, tabun and GF. Toxicology 1992 72 : 99 105.
10. Kassa J, Bajgar J. Comparison of the efficacy of HI-6 and obidoxime against cyclohexyl methylphosphonofluoridate (GF) in rats. Hum Exp Toxicol 1995 14 : 923 8.
11. Worek F, Eyer P, Szinicz L. Inhibition, reactivation and aging kinetics of cyclohexyl-phosphonofluoridate-inhibited human cholinesterases. Arch Toxicol 1998 72 : 580 7.
12. Lundy PM, Hill I, Lecavalier P, Hamilton MG, Vair C, Davidson C et al. The pharmacokinetics and pharmacodynamics of two HI-6 salts in swine and efficacy in the treatment of GF and soman poisoning. Toxicology 2005 208 : 399 409.
13. Lundy PM, Raveh L, Amitai G. Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning. Toxicol Rev 2006 25 : 231 43.
14. Cassel G, Karlsson L, Waara L, Wee Ang K, Goransson-Nyberg A. Pharmacokinetics and effects of HI-6 in blood and brain of soman-intoxicated rats: a microdialysis study. Eur J Pharmacol 1997 332 : 43 52.
15. Sakurada K, Matsubara K, Shimizu K, Shiono H, Seto Y, Tsuge K et al. Pralidoxime iodide (2-PAM) penetrates across the blood-brain barrier. Neurochem Res 2003 28 : 1401 7.
16. Musilek K, Holas O, Jun D, Dohnal V, Gunn-Moore F, Opletalova V et al. Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker - preparation and reactivation of tabun and paraoxon-inhibited acetylcholinesterase. Bioorg Med Chem 2007 15 : 6733 41.
17. Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Opletalova V et al. Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase. J Enzyme Inhib Med Chem 2008 23 : 70 6.
18. Kassa J, Karasova J, Musilek K, Kuca K, Bajgar J. An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice. Clin Toxicol 2008 DOI:.
19. Frantik E, Hornychova M. Clustering of neurobehavioral measures of toxicity. Homeostasis 1995 36 : 19 25.
20. Hornychova M, Frantik E, Kubat J, Formanek J. Neurotoxicity profile of supermethrin, a new pyrethroid insecticide. Cent Eur J Public Health 1995 3 : 210 8.
21. Moser VC, Tilson H, McPhail RC, Becking GC, Cuomo V, Frantik E et al. The IPCS collaborative study on neurobehavioral screening methods: II. Protocol design and testing procedures. Neurotoxicology 1997 18 : 929 38.
22. McDonough JH Jr., Shih T-M. Neuropharmacological modulation of nerve agent-induced seizure and neuropathology. Neurosci Biobehav Rev 1997 21 : 559 79.
23. Kuca K, Cabal J, Jun D, Kassa J, Bartosova L, Kunesova G. In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions. J Appl Toxicol 2005 25 : 296 300.
24. Kuca K, Cabal J, Jun D, Bajgar J, Hrabinova M. Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterase. J Enzyme Inhib Med Chem 2006 21 : 663 6.
25. Kuca K, Jun D, Musilek K. Structural requirements of acetylcholinesterase reactivators. Mini Rev Med Chem 2006 6 : 109 20.
26. Musilek K, Kuca K, Jun D, Dolezal M. Progress in synthesis of new acetylcholinesterase reactivators during the period 1990-2004. Curr Org Chem 2007 11 : 229 38.
27. Kuca J, Patocka J. Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes. J Enzyme Inhib Med Chem 2004 19 : 39 43.
28. Kassa J, Cabal J. A comparison of the efficacy of acetylcholinesterase reactivators against cyclohexyl methylphosphonofluoridate (GF agent) by in vitro and in vivo methods. Pharmacol Toxicol 1999 84 : 41 5.
29. Wiener SW, Hoffman RS. Nerve agents: a comprehensive review. J Intensive Care Med 2004 19 : 22 37.