Evidence that altered amygdala activity in schizophrenia is related to clinical state and not genetic risk

American Journal of Psychiatry

Volumn 166, Issue 2, 2009, Pages 216-225

  Rasetti, Roberta ^b   Mattay, Venkata S ^b   Wiedholz, Lisa M ^b   Kolachana, Bhaskar S ^b   Hariri, Ahmad R ^b   Callicott, Joseph H ^b   Meyer Lindenberg, Andreas ^b   Weinberger, Daniel R ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPROMAZINE;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; BRAIN FUNCTION; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC RISK; HEALTH STATUS; HUMAN; MALE; MENTAL FUNCTION; MENTAL TASK; OXYGEN BLOOD LEVEL; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; SIBLING; TASK PERFORMANCE; WORKING MEMORY;

ADULT; AMYGDALA; ANGER; COGNITION DISORDERS; DOMINANCE, CEREBRAL; FACIAL EXPRESSION; FEAR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GYRUS CINGULI; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MAGNETIC RESONANCE IMAGING; MALE; MEMORY, SHORT-TERM; NERVE NET; NEUROPSYCHOLOGICAL TESTS; OXYGEN; PATTERN RECOGNITION, VISUAL; PHENOTYPE; SCHIZOPHRENIA;

EID: 60349127721     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2008.08020261     Document Type: Article

References (39)

1. LeDoux J: The amygdala. Curr Biol 2007; 17:R868-R874
2. Pinkham AE, Gur RE, Gur RC: Affect recognition deficits in schizophrenia: neural substrates and psychopharmacological implications. Expert Rev Neurother 2007; 7:807-816
3. Brunet-Gouet E, Decety J: Social brain dysfunctions in schizophrenia: a review of neuroimaging studies. Psychiatry Res 2006; 148:75-92
4. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, Weinberger DR: Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297:400-403
5. Hariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF, Weinberger DR: A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry 2005; 62:146-152
6. Heinz A, Braus DF, Smolka MN, Wrase J, Puls I, Hermann D, Klein S, Grüsser SM, Flor H, Schumann G, Mann K, Büchel C: Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci 2005; 8:20-21
7. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR: 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 2005; 8:828-834
8. 158Met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci 2005; 25:836-842
9. 158Met genotype and neural mechanisms related to affective arousal and regulation. Arch Gen Psychiatry 2006; 63:1396-1406
10. Meyer-Lindenberg A, Buckholtz JW, Kolachana B, Hariri AR, Pezawas L, Blasi G, Wabnitz A, Honea R, Verchinski B, Callicott JH, Egan M, Mattay V, Weinberger DR: Neural mechanisms of genetic risk for impulsivity and violence in humans. Proc Natl Acad Sci U S A 2006; 103:6269-6274
11. Toomey R, Seidman LJ, Lyons MJ, Faraone SV, Tsuang MT: Poor perception of nonverbal social-emotional cues in relatives of schizophrenic patients. Schizophr Res 1999; 40:121-130
12. Bolte S, Poustka F: The recognition of facial affect in autistic and schizophrenic subjects and their first-degree relatives. Psychol Med 2003; 33:907-915
13. Gur RE, Nimgaonkar VL, Almasy L, Calkins ME, Ragland JD, Pogue-Geile MF, Kanes S, Blangero J, Gur RC: Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia. Am J Psychiatry 2007; 164:813-819
14. Edwards J, Jackson HJ, Pattison PE: Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review. Clin Psychol Rev 2002; 22:789-832
15. Goldberg TE, Torrey EF, Gold JM, Ragland JD, Bigelow LB, Weinberger DR: Learning and memory in monozygotic twins discordant for schizophrenia. Psychol Med 1993; 23:71-85
16. Goldberg TE, Torrey EF, Gold JM, Bigelow LB, Ragland RD, Taylor E, Weinberger DR: Genetic risk of neuropsychological impairment in schizophrenia: a study of monozygotic twins discordant and concordant for the disorder. Schizophr Res 1995; 17:77-84
17. Cannon TD, Huttunen MO, Lonnqvist J, Tuulio-Henriksson A, Pirkola T, Glahn D, Finkelstein J, Hietanen M, Kaprio J, Koskenvuo M: The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet 2000; 67:369-382
18. Aleman A, Kahn RS: Strange feelings: Do amygdala abnormalities dysregulate the emotional brain in schizophrenia? Prog Neurobiol 2005; 77:283-298
19. Braff DL, Freedman R, Schork NJ, Gottesman II: Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull 2007; 33:21-32
20. Callicott JH, Weinberger DR: Brain imaging as an approach to phenotype characterization for genetic studies of schizophrenia. Methods Mol Med 2003; 77:227-247
21. Callicott JH, Egan MF, Mattay VS, Bertolino A, Bone AD, Verchinksi B, Weinberger DR: Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am J Psychiatry 2003; 160:709-719
22. 108/158Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 2001; 98:6917-6922
23. Woods SW: Chlorpromazine equivalent doses for the newer atypical antipsychotics. J Clin Psychiatry 2003; 64:663-667
24. Serra M, Salgado-Pineda P, Delaveau P, Fakra E, Gasto C, Blin O: Effects of antidepressant drugs on emotion. Clin Neuropharmacol 2006; 29:170-185
25. Kay SR, Fiszbein A, Opler LA: The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13:261-276
26. Ekman P, Friesen WV: Pictures of Facial Affect. Palo Alto, Calif, Consulting Psychologists Press, 1976
27. Fisher RA: On the "probable error" of a coefficient of correlation deduced from a small sample. Metron 1921; 1:3-32
28. Canli T, Desmond JE, Zhao Z, Gabrieli JD: Sex differences in the neural basis of emotional memories. Proc Natl Acad Sci U S A 2002; 99:10789-10794
29. Canli T, Zhao Z, Brewer J, Gabrieli JD, Cahill L: Event-related activation in the human amygdala associates with later memory for individual emotional experience. J Neurosci 2000; 20:RC99
30. Phelps EA, O'Connor KJ, Gatenby JC, Gore JC, Grillon CD, Davis M: Activation of the left amygdala to a cognitive representation of fear. Nat Neurosci 2001; 4:437-441
31. Phelps EA, Delgado MR, Nearing KI, LeDoux JE: Extinction learning in humans: role of the amygdala and vmPFC. Neuron 2004; 43:897-905
32. Habel U, Klein M, Shah NJ, Toni I, Zilles K, Falkai P, Schneider F: Genetic load on amygdala hypofunction during sadness in nonaffected brothers of schizophrenia patients. Am J Psychiatry 2004; 161:1806-1813
33. Kosaka H, Omori M, Murata T, Iidaka T, Yamada H, Okada T, Takahashi T, Sadato N, Itoh H, Yonekura Y, Wada Y: Differential amygdala response during facial recognition in patients with schizophrenia: an fMRI study. Schizophr Res 2002; 57:87-95
34. Holt DJ, Kunkel L, Weiss AP, Goff DC, Wright CI, Shin LM, Rauch SL, Hootnick J, Heckers S: Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia. Schizophr Res 2006; 82:153-162
35. Russell TA, Reynaud E, Kucharska-Pietura K, Ecker C, Benson PJ, Zelaya F, Giampietro V, Brammer M, David A, Phillips ML: Neural responses to dynamic expressions of fear in schizophrenia. Neuropsychologia 2007; 45:107-123
36. Phillips ML, Drevets WC, Rauch SL, Lane R: Neurobiology of emotion perception, II: implications for major psychiatric disorders. Biol Psychiatry 2003; 54:515-528
37. Buckholtz JW, Callicott JH, Kolachana B, Hariri AR, Goldberg TE, Genderson M, Egan MF, Mattay VS, Weinberger DR, Meyer-Lindenberg A: Genetic variation in MAO-A modulates ventro-medial prefrontal circuitry mediating individual differences in human personality. Mol Psychiatry 2008; 13:313-324
38. Wechsler D: Wechsler Adult Intelligence Scale - Revised. San Antonio, Tex, Psychological Corporation, 1981
39. Oldfield RC: The assessment and analysis of handedness: The Edinburgh Inventory. Neuropsychologia 1971; 9:97-113