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Volumn 69, Issue 3, 2009, Pages 194-202

IC31®, a two-component novel adjuvant mixed with a conjugate vaccine enhances protective immunity against pneumococcal disease in neonatal mice

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL POLYSACCHARIDE; BACTERIAL POLYSACCHARIDE TETANUS TOXOID CONJUGATE; CPG OLIGODEOXYNUCLEOTIDE; IC 31; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3 ANTIBODY; IMMUNOLOGICAL ADJUVANT; TETANUS TOXOID; UNCLASSIFIED DRUG; BACTERIUM ANTIBODY; LYSYL LEUCYL LYSYL LEUCYL LEUCYL LEUCYL LEUCYL LEUCYL LYSYL LEUCYL LYSINE; LYSYL-LEUCYL-LYSYL-LEUCYL-LEUCYL-LEUCYL-LEUCYL-LEUCYL-LYSYL-LEUCYL-LYSINE; OLIGODEOXYRIBONUCLEOTIDE; OLIGOPEPTIDE; PNEUMOCOCCUS VACCINE; VACCINE;

EID: 60349123505     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2008.02225.x     Document Type: Article
Times cited : (41)

References (37)
  • 1
    • 0026717596 scopus 로고
    • Thymus-independent and thymus-dependent responses to polysaccharide antigens
    • Stein KE. Thymus-independent and thymus-dependent responses to polysaccharide antigens. J Infect Dis 1992 165 (Suppl. 1 S49 52.
    • (1992) J Infect Dis , vol.165 , Issue.1
    • Stein, K.E.1
  • 2
    • 0034063425 scopus 로고    scopus 로고
    • Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group
    • Black S, Shinefield H, Fireman B et al. Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group. Pediatr Infect Dis J 2000 19 : 187 95.
    • (2000) Pediatr Infect Dis J , vol.19 , pp. 187-95
    • Black, S.1    Shinefield, H.2    Fireman, B.3
  • 3
    • 20144367956 scopus 로고    scopus 로고
    • Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in Gambia: Randomised, double-blind, placebo-controlled trial
    • Cutts FT, Zaman SM, Enwere G et al. Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in Gambia: randomised, double-blind, placebo-controlled trial. Lancet 2005 365 : 1139 46.
    • (2005) Lancet , vol.365 , pp. 1139-46
    • Cutts, F.T.1    Zaman, S.M.2    Enwere, G.3
  • 4
    • 0036377943 scopus 로고    scopus 로고
    • Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than five years of age for prevention of pneumonia
    • Black SB, Shinefield HR, Ling S et al. Effectiveness of heptavalent pneumococcal conjugate vaccine in children younger than five years of age for prevention of pneumonia. Pediatr Infect Dis J 2002 21 : 810 5.
    • (2002) Pediatr Infect Dis J , vol.21 , pp. 810-5
    • Black, S.B.1    Shinefield, H.R.2    Ling, S.3
  • 5
    • 34548289498 scopus 로고    scopus 로고
    • Surveillance for invasive pneumococcal disease during 2000-2005 in a population of children who received 7-valent pneumococcal conjugate vaccine
    • Black S, France EK, Isaacman D et al. Surveillance for invasive pneumococcal disease during 2000-2005 in a population of children who received 7-valent pneumococcal conjugate vaccine. Pediatr Infect Dis J 2007 26 : 771 7.
    • (2007) Pediatr Infect Dis J , vol.26 , pp. 771-7
    • Black, S.1    France, E.K.2    Isaacman, D.3
  • 6
    • 0035825720 scopus 로고    scopus 로고
    • Efficacy of a pneumococcal conjugate vaccine against acute otitis media
    • Eskola J, Kilpi T, Palmu A et al. Efficacy of a pneumococcal conjugate vaccine against acute otitis media. N Engl J Med 2001 344 : 403 9.
    • (2001) N Engl J Med , vol.344 , pp. 403-9
    • Eskola, J.1    Kilpi, T.2    Palmu, A.3
  • 7
    • 37549065537 scopus 로고    scopus 로고
    • Randomized, controlled trial efficacy of pneumococcal conjugate vaccine against otitis media among Navajo and White Mountain Apache infants
    • O'Brien KL, David AB, Chandran A et al. Randomized, controlled trial efficacy of pneumococcal conjugate vaccine against otitis media among Navajo and White Mountain Apache infants. Pediatr Infect Dis J 2008 27 : 71 3.
    • (2008) Pediatr Infect Dis J , vol.27 , pp. 71-3
    • O'Brien, K.L.1    David, A.B.2    Chandran, A.3
  • 9
    • 34250331531 scopus 로고    scopus 로고
    • The perfect mix: Recent progress in adjuvant research
    • Guy B. The perfect mix: recent progress in adjuvant research. Nat Rev Microbiol 2007 5 : 505 17.
    • (2007) Nat Rev Microbiol , vol.5 , pp. 505-17
    • Guy, B.1
  • 10
    • 34447128388 scopus 로고    scopus 로고
    • Antiinfective applications of toll-like receptor 9 agonists
    • Krieg AM. Antiinfective applications of toll-like receptor 9 agonists. Proc Am Thorac Soc 2007 4 : 289 94.
    • (2007) Proc Am Thorac Soc , vol.4 , pp. 289-94
    • Krieg, A.M.1
  • 11
    • 0035477969 scopus 로고    scopus 로고
    • Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells
    • Takeshita F, Leifer CA, Gursel I et al. Cutting edge: role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J Immunol 2001 167 : 3555 8.
    • (2001) J Immunol , vol.167 , pp. 3555-8
    • Takeshita, F.1    Leifer, C.A.2    Gursel, I.3
  • 12
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi H, Takeuchi O, Kawai T et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000 408 : 740 5.
    • (2000) Nature , vol.408 , pp. 740-5
    • Hemmi, H.1    Takeuchi, O.2    Kawai, T.3
  • 13
    • 0034698739 scopus 로고    scopus 로고
    • Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6
    • Hacker H, Vabulas RM, Takeuchi O, Hoshino K, Akira S, Wagner H. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J Exp Med 2000 192 : 595 600.
    • (2000) J Exp Med , vol.192 , pp. 595-600
    • Hacker, H.1    Vabulas, R.M.2    Takeuchi, O.3    Hoshino, K.4    Akira, S.5    Wagner, H.6
  • 14
    • 9144238063 scopus 로고    scopus 로고
    • Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities
    • Vollmer J, Weeratna R, Payette P et al. Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur J Immunol 2004 34 : 251 62.
    • (2004) Eur J Immunol , vol.34 , pp. 251-62
    • Vollmer, J.1    Weeratna, R.2    Payette, P.3
  • 15
    • 0033962266 scopus 로고    scopus 로고
    • Innate immunity and the normal microflora
    • Boman HG. Innate immunity and the normal microflora. Immunol Rev 2000 173 : 5 16.
    • (2000) Immunol Rev , vol.173 , pp. 5-16
    • Boman, H.G.1
  • 16
    • 0036606951 scopus 로고    scopus 로고
    • Mammalian defensins in immunity: More than just microbicidal
    • Yang D, Biragyn A, Kwak LW, Oppenheim JJ. Mammalian defensins in immunity: more than just microbicidal. Trends Immunol 2002 23 : 291 6.
    • (2002) Trends Immunol , vol.23 , pp. 291-6
    • Yang, D.1    Biragyn, A.2    Kwak, L.W.3    Oppenheim, J.J.4
  • 17
    • 0035879198 scopus 로고    scopus 로고
    • Cutting edge: IFN-inducible ELR-CXC chemokines display defensin-like antimicrobial activity
    • Cole AM, Ganz T, Liese AM, Burdick MD, Liu L, Strieter RM. Cutting edge: IFN-inducible ELR-CXC chemokines display defensin-like antimicrobial activity. J Immunol 2001 167 : 623 7.
    • (2001) J Immunol , vol.167 , pp. 623-7
    • Cole, A.M.1    Ganz, T.2    Liese, A.M.3    Burdick, M.D.4    Liu, L.5    Strieter, R.M.6
  • 18
    • 0028088351 scopus 로고
    • Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus
    • Alvarez-Bravo J, Kurata S, Natori S. Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus. Biochem J 1994 302 (Pt 2 535 8.
    • (1994) Biochem J , vol.302 , Issue.2 , pp. 535-8
    • Alvarez-Bravo, J.1    Kurata, S.2    Natori, S.3
  • 19
    • 4043049496 scopus 로고    scopus 로고
    • The artificial antimicrobial peptide KLKLLLLLKLK induces predominantly a TH2-type immune response to co-injected antigens
    • Fritz JH, Brunner S, Birnstiel ML et al. The artificial antimicrobial peptide KLKLLLLLKLK induces predominantly a TH2-type immune response to co-injected antigens. Vaccine 2004 22 : 3274 84.
    • (2004) Vaccine , vol.22 , pp. 3274-84
    • Fritz, J.H.1    Brunner, S.2    Birnstiel, M.L.3
  • 20
    • 33744806358 scopus 로고    scopus 로고
    • IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses
    • Schellack C, Prinz K, Egyed A et al. IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses. Vaccine 2006 24 : 5461 72.
    • (2006) Vaccine , vol.24 , pp. 5461-72
    • Schellack, C.1    Prinz, K.2    Egyed, A.3
  • 21
    • 33744815623 scopus 로고    scopus 로고
    • Protective immunity to tuberculosis with Ag85B-ESAT-6 in a synthetic cationic adjuvant system IC31
    • Agger EM, Rosenkrands I, Olsen AW et al. Protective immunity to tuberculosis with Ag85B-ESAT-6 in a synthetic cationic adjuvant system IC31. Vaccine 2006 24 : 5452 60.
    • (2006) Vaccine , vol.24 , pp. 5452-60
    • Agger, E.M.1    Rosenkrands, I.2    Olsen, A.W.3
  • 22
    • 44749084178 scopus 로고    scopus 로고
    • The novel adjuvant IC31(R) strongly improves influenza vaccine-specific cellular and humoral immune responses in young adult and aged mice
    • Riedl K, Riedl R, von Gabain A, Nagy E, Lingnau K. The novel adjuvant IC31(R) strongly improves influenza vaccine-specific cellular and humoral immune responses in young adult and aged mice. Vaccine 2008 26 : 3461 8.
    • (2008) Vaccine , vol.26 , pp. 3461-8
    • Riedl, K.1    Riedl, R.2    Von Gabain, A.3    Nagy, E.4    Lingnau, K.5
  • 23
    • 45849140223 scopus 로고    scopus 로고
    • Protective anti-mycobacterial T cell responses through exquisite in vivo activation of vaccine-targeted dendritic cells
    • Kamath AT, Valenti MP, Rochat AF et al. Protective anti-mycobacterial T cell responses through exquisite in vivo activation of vaccine-targeted dendritic cells. Eur J Immunol 2008 38 : 1247 56.
    • (2008) Eur J Immunol , vol.38 , pp. 1247-56
    • Kamath, A.T.1    Valenti, M.P.2    Rochat, A.F.3
  • 24
    • 0033822386 scopus 로고    scopus 로고
    • Pneumococcal pneumonia and bacteremia model in mice for the analysis of protective antibodies
    • Saeland E, Vidarsson G, Jonsdottir I. Pneumococcal pneumonia and bacteremia model in mice for the analysis of protective antibodies. Microb Pathog 2000 29 : 81 91.
    • (2000) Microb Pathog , vol.29 , pp. 81-91
    • Saeland, E.1    Vidarsson, G.2    Jonsdottir, I.3
  • 25
    • 0036182480 scopus 로고    scopus 로고
    • Intranasal immunization with pneumococcal conjugate vaccines with LT-K63, a nontoxic mutant of heat-labile enterotoxin, as adjuvant rapidly induces protective immunity against lethal pneumococcal infections in neonatal mice
    • Jakobsen H, Bjarnarson SP, Del Giudice G, Moreau M, Siegrist CA, Jonsdottir I. Intranasal immunization with pneumococcal conjugate vaccines with LT-K63, a nontoxic mutant of heat-labile enterotoxin, as adjuvant rapidly induces protective immunity against lethal pneumococcal infections in neonatal mice. Infect Immun 2002 70 : 1443 52.
    • (2002) Infect Immun , vol.70 , pp. 1443-52
    • Jakobsen, H.1    Bjarnarson, S.P.2    Del Giudice, G.3    Moreau, M.4    Siegrist, C.A.5    Jonsdottir, I.6
  • 26
    • 0032769109 scopus 로고    scopus 로고
    • Intranasal immunization with pneumococcal polysaccharide conjugate vaccines protects mice against invasive pneumococcal infections
    • Jakobsen H, Saeland E, Gizurarson S, Schulz D, Jonsdottir I. Intranasal immunization with pneumococcal polysaccharide conjugate vaccines protects mice against invasive pneumococcal infections. Infect Immun 1999 67 : 4128 33.
    • (1999) Infect Immun , vol.67 , pp. 4128-33
    • Jakobsen, H.1    Saeland, E.2    Gizurarson, S.3    Schulz, D.4    Jonsdottir, I.5
  • 27
    • 0035858127 scopus 로고    scopus 로고
    • Neonatal and early life vaccinology
    • Siegrist CA. Neonatal and early life vaccinology. Vaccine 2001 19 : 3331 46.
    • (2001) Vaccine , vol.19 , pp. 3331-46
    • Siegrist, C.A.1
  • 28
    • 17644364706 scopus 로고    scopus 로고
    • Can successful vaccines teach us how to induce efficient protective immune responses?
    • Lambert PH, Liu M, Siegrist CA. Can successful vaccines teach us how to induce efficient protective immune responses? Nat Med 2005 11 : S54 62.
    • (2005) Nat Med , vol.11
    • Lambert, P.H.1    Liu, M.2    Siegrist, C.A.3
  • 29
    • 0032755492 scopus 로고    scopus 로고
    • Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections
    • Jakobsen H, Schulz D, Pizza M, Rappuoli R, Jonsdottir I. Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections. Infect Immun 1999 67 : 5892 7.
    • (1999) Infect Immun , vol.67 , pp. 5892-7
    • Jakobsen, H.1    Schulz, D.2    Pizza, M.3    Rappuoli, R.4    Jonsdottir, I.5
  • 31
    • 0035863550 scopus 로고    scopus 로고
    • Serum samples from infants vaccinated with a pneumococcal conjugate vaccine, PncT, protect mice against invasive infection caused by Streptococcus pneumoniae serotypes 6A and 6B
    • Saeland E, Jakobsen H, Ingolfsdottir G, Sigurdardottir ST, Jonsdottir I. Serum samples from infants vaccinated with a pneumococcal conjugate vaccine, PncT, protect mice against invasive infection caused by Streptococcus pneumoniae serotypes 6A and 6B. J Infect Dis 2001 183 : 253 60.
    • (2001) J Infect Dis , vol.183 , pp. 253-60
    • Saeland, E.1    Jakobsen, H.2    Ingolfsdottir, G.3    Sigurdardottir, S.T.4    Jonsdottir, I.5
  • 34
    • 0031460777 scopus 로고    scopus 로고
    • Immunostimulatory DNA: Sequence-dependent production of potentially harmful or useful cytokines
    • Lipford GB, Sparwasser T, Bauer M et al. Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur J Immunol 1997 27 : 3420 6.
    • (1997) Eur J Immunol , vol.27 , pp. 3420-6
    • Lipford, G.B.1    Sparwasser, T.2    Bauer, M.3
  • 35
    • 0030897625 scopus 로고    scopus 로고
    • Bacterial DNA causes septic shock
    • Sparwasser T, Miethke T, Lipford G et al. Bacterial DNA causes septic shock. Nature 1997 386 : 336 7.
    • (1997) Nature , vol.386 , pp. 336-7
    • Sparwasser, T.1    Miethke, T.2    Lipford, G.3
  • 36
    • 0014528517 scopus 로고
    • Human immunity to the meningococcus. V. the effect of immunization with meningococcal group C polysaccharide on the carrier state
    • Gotschlich EC, Goldschneider I, Artenstein MS. Human immunity to the meningococcus. V. The effect of immunization with meningococcal group C polysaccharide on the carrier state. J Exp Med 1969 129 : 1385 95.
    • (1969) J Exp Med , vol.129 , pp. 1385-95
    • Gotschlich, E.C.1    Goldschneider, I.2    Artenstein, M.S.3
  • 37
    • 60349094904 scopus 로고    scopus 로고
    • Formulations of five conserved meningococcal B virulence proteins, 5CVMB, with safe adjuvants elicit broadly protective antibody responses in neonatal mice
    • Abstract P103. In: ed. Rotterdam, The Netherlands, 7-12 September, Beurs World Trade Center, pp.
    • Eiosson SF, Giuliani M, Ólafsdóttir TA, Pizza M, Rappuoli R, Jónsdóttir I. Formulations of five conserved meningococcal B virulence proteins, 5CVMB, with safe adjuvants elicit broadly protective antibody responses in neonatal mice. Abstract P103. In : ed. Proceedings of the 16th International Pathogenic Neisseria Conference, Rotterdam, The Netherlands, 7-12 September, 2008. Beurs World Trade Center, pp. 173 4.
    • (2008) Proceedings of the 16th International Pathogenic Neisseria Conference , pp. 173-4
    • Eiosson, S.F.1    Giuliani, M.2    Ólafsdóttir, T.A.3    Pizza, M.4    Rappuoli, R.5    Jónsdóttir, I.6


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