Synthesis, analgesic and anti-inflammatory activities of novel 3-(4-acetamido-benzyl)-5-substituted-1,2,4-oxadiazoles

European Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2009, Pages 794-799

  Farooqui, Mazahar ^a   Bora, Rajesh ^a,b   Patil, C R ^c  

^a Aurangabad College for Women   (India)

^b Wockhardt Research Centre   (India)

^c R C PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

Author keywords

1,2,4 Oxadiazoles; Analgesic activity; Anti inflammatory activity; Diclofenac sodium; Hydroxycarbamidoylmethyl

Indexed keywords

3 [3 (4 ACETYLAMINOBENZYL)[1,2,4]OXADIAZOL 5 YL] N (2 FLUOROPHENYL)PROPIONAMIDE; 3 [3 (4 ACETYLAMINOBENZYL)[1,2,4]OXADIAZOL 5 YL] N (2 METHOXYPHENYL)PROPIONAMIDE; 3 [3 (4 ACETYLAMINOBENZYL)[1,2,4]OXADIAZOL 5 YL] N (2,4 DIMETHOXYPHENYL)PROPIONAMIDE; 3 [3 (4 ACETYLAMINOBENZYL)[1,2,4]OXADIAZOL 5 YL] N (3 ETHYNYLPHENYL)PROPIONAMIDE; 3 [3 (4 ACETYLAMINOBENZYL)[1,2,4]OXADIAZOL 5 YL] N (4 FLUOROPHENYL)PROPIONAMIDE; 3 [3 (4 ACETYLAMINOBENZYL)[1,2,4]OXADIAZOL 5 YL] N BENZYLPROPIONAMIDE; 3 [3 (4 ACETYLAMINOBENZYL)[1,2,4]OXADIAZOL 5 YL] N PYRIDIN 3 YLPROPIONAMIDE; 3 [3 (4 ACETYLAMINOBENZYL)[1,2,4]OXADIAZOL 5 YL]PROPIONIC ACID; ACETIC ACID; CARRAGEENAN; DICLOFENAC; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; PAW EDEMA; WRITHING TEST;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; DRUG EVALUATION, PRECLINICAL; EDEMA; MICE; OXADIAZOLES; PAIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60349090991     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.05.022     Document Type: Article

References (31)

1. Kontogiorgis C.A. J. Med. Chem. 48 (2005) 6400-6408
2. Habeeb Amgad G., and Praveen Rao P.N. J. Med. Chem. 44 (2001) 2921-2927
3. Xie W.L., and Chipmann J.G. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 2692-2696
4. Allison M.C., and Howatson A.C. N. Engl. J. Med. 327 (1992) 749-754
5. Botting J.H. Drugs Today 35 (1999) 225
6. Ricardo A.W., and Neves F. Molecules 11 (2006) 318-324
7. Hemming K. J. Chem. Res. 216 (2001) 209-216
8. Glushkov V.A., and Anikina L.V. Pharma. Chem. J. 38 (2004) 86-89
9. Srivastava R.M., and Morais L.P.F. Heterocycl. Commun. 6 (2000) 41-48
10. Jonathan R.Y., and Robert J.D. Tetrahedron Lett. 39 (1998) 3931
11. Clapp L.B. Adv. Heterocycl. Chem. (1976) 65
12. Orlek B.S., and Balney F.E. J. Med. Chem. 34 (1991) 2726
13. Watjen F., and Baker R. J. Med. Chem. 32 (1989) 2282
14. Carroll F.L., and Gray J.L. J. Med. Chem. 36 (1993) 2886
15. Diana G.D., and Volkots D.L. J. Med. Chem. 37 (1994) 2421
16. Ankersen M., and Peschke B. Bioorg. Med. Chem. Lett. 7 (1997) 1293
17. Chen C., and Senanayake C.H. J. Org. Chem. 59 (1994) 3738
18. A.S. Sousa, French Patent 1,363,235, 1964
19. Chem. Abstr. 62 (1965) 5282
20. H. Ulrich, H.G. Wilfried, Ger Offen. DE 3,805,698, 1989.
21. Afiatpour P., and Srivastava R.M. Braz. J. Med. Biol. Res. 27 (1994) 1403
22. Dahlgren S.E., and Dalham T. Acta Pharmacol. Toxicol. 31 (1972) 193
23. Dirk A., and Heerding G.C. Bioorg. Med. Chem. Lett. 11 (2001) 2061
24. Vu C.B., and Corpuz E.G. J. Med. Chem. 42 (1999) 20
25. Bethge K., and Pertz H.H. Arch. Pharm. 78 (2005) 338
26. Cottrell D.M., and Capers J. Bioorg. Med. Chem. 12 (2004) 2815-2824
27. Weidner-Wells M.A., and Henninger T.C. Bioorg. Med. Chem. Lett. 14 (2004) 4307-4311
28. Bora R., and Farooqui M. J. Heterocycl. Chem. 44 (2007) 645
29. G. Leandri, L. Maioli, Boll. Sci. Fac. Chim. Ind., Bolgna 15 No. 3, (1957) 5762 Chem. Abstr. 52 (1958) 7291h.
30. Alvarez M.E., Rotelli A.E., Pelzer L.E., Saad J.R., and Giordano O. Il Farmaco 55 (2000) 502-505
31. Kosher R., Anderson M., and deBeer E.J. Fed. Proc. 18 (1959) 412