The influence of an ethylene spacer on the 5-HT1A and 5-HT2A receptor affinity of arylpiperazine derivatives of amides with N-acylated amino acids and 3-differently substituted pyrrolidine-2,5-diones

European Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2009, Pages 800-808

  Zajdel, Paweł ^a   Subra, Gilles ^b   Verdie, Pascal ^b   Bojarski, Andrzej J ^c   Duszyńska, Beata ^c   Basista, Katarzyna ^a   Obniska, Jolanta ^a   Martinez, Jean ^b   Pawłowski, Maciej ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b UNIVERSITÉ DE MONTPELLIER   (France)

^c INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

2 Azaspiro 4.5 decane 1,3 dione; 5 HT1A 5 HT2A receptor ligands; Long chain arylpiperazines; Prolinamides; Pyrrolidine 2,5 dione; Pyrrolidine 5 one carboxamide; Solid phase synthesis; Spirosuccinimides; Succinimides

Indexed keywords

BUSPIRONE; CLOZAPINE; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SUCCINIMIDE DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; RECEPTOR AFFINITY;

AMIDES; AMINO ACIDS; ETHYLENES; HUMANS; HYDROPHOBICITY; PIPERAZINES; PROTEIN BINDING; PYRROLIDINES; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60349083385     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.05.021     Document Type: Article

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