Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family

Journal of Heredity

Volumn 100, Issue 2, 2009, Pages 241-245

  Gillenwaters, Erin N ^a   Seabury, Christopher M ^a   Elliott, Janice S ^a   Womack, James E ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Antimicrobial peptide; Cathelicidin; Cattle; Innate immunity

Indexed keywords

CATHELICIDIN;

ARTICLE; BOS INDICUS; BOS TAURUS; CATHL GENE; CATTLE; GENE; GENE SEQUENCE; INDEL MUTATION; INNATE IMMUNITY; MALE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CASE-CONTROL STUDIES; CATTLE; GENE FREQUENCY; IMMUNITY, INNATE; INDEL MUTATION; MULTIGENE FAMILY; POINT MUTATION; POLYMORPHISM, GENETIC; PROTEINS; SEQUENCE ANALYSIS, DNA;

BOS; BOS INDICUS; BOS TAURUS; BOVINAE; MAMMALIA;

EID: 60249096466     PISSN: 00221503     EISSN: 14657333     Source Type: Journal    
DOI: 10.1093/jhered/esn112     Document Type: Article

References (16)

1. Bals R, Weiner DJ, Meegalla RL, Wilson JM. 1999. Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. J Clin Invest. 103:1113-1117.
2. Benincasa M, Skerlavaj B, Gennaro R, Pellegrini A, Zanetti M. 2003. In vitro and in vivo antimicrobial activity of two alpha-helical cathelicidin peptides and of their synthetic analogs. Peptides. 24:1723-1731.
3. Braff MG, Bardan A, Nizet V, Gallo RL. 2005. Cutaneous defense mechanisms by antimicrobial peptides. J Invest Dermatol. 125:9-13.
4. Gennaro R, Scocchi M, Merluzzi L, Zanetti M. 1998. Biological characterization of a novel mammalian antimicrobial peptide. Biochim Biophys Acta. 1425:361-368.
5. Lee PH, Ohtake T, Zaiou M, Murakami M, Rudisill JA, Lin KH, Gallo RL. 2005. Expression of an additional cathelicidin antimicrobial peptide protects against bacterial skin infection. Proc Natl Acad Sci USA. 102: 3750-3755.
6. Mookherjee N, Wilson H, Doria S, Popowych Y, Falsafi R, Yu J, Li Y, Veatch S, Roche F, Brown K, et al. 2006. Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide. J Leukoc Biol. 80:1563-1574.
7. Oklahoma State University Department of Animal Science, breeds of cattle (http://www.ansi.okstate.edu/breeds/cattle/).
8. Oppenheim JJ, Yang D. 2005. Alarmins: chemotactic activators of immune responses. Curr Opin Immulol. 17:359-365.
9. Pütsep K, Carlsson G, Boman HG, Andersson M. 2002. Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. Lancet. 360:1144-1149.
10. Seabury CM, Cargill EJ, Womack JE. 2007. Sequence variability and protein domain architectures for bovine Toll-like receptors 1, 5, and 10. Genomics. 90:502-515.
11. Seabury CM, Honeycutt RL, Rooney AP, Halbert ND, Derr JN. 2004. Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3. Proc Natl Acad Sci USA. 101:15142-15147.
12. Seabury CM, Womack JE. 2008. Analysis of sequence variability and protein domain architectures for bovine peptidoglycan receptor protein 1 (PGLYRP1) and toll-like receptors 2 and 6. Genomics. 92:235-245.
13. Tomasinsig L, Zanetti M. 2005. The cathelicidins - structure, function, and evolution. Curr Protein Pept Sci. 6:23-24.
14. Yim S, Dhawan P, Ragunath C, Christakos S, Diamond G. 2007. Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25- dihydroxyvitamin D(3). J Cyst Fibros. 6:403-410.
15. Zanetti M. 2004. Cathelicidins, multifunctional peptides of the innate immunity. J Leukoc Biol. 75:39-48.
16. Zanetti M, Gennaro R, Skerlavaj B, Tomasinsig L, Circo R. 2002. Cathelicidin peptides as candidates for a novel class of antimicrobials. Curr Pharm Des. 9:779-793.