Cilostazol protects against hemorrhagic transformation in mice transient focal cerebral ischemia-induced brain damage

Neuroscience Letters

Volumn 452, Issue 2, 2009, Pages 156-161

  Nonaka, Yuko ^a,b   Tsuruma, Kazuhiro ^a   Shimazawa, Masamitsu ^a   Yoshimura, Shinichi ^b   Iwama, Toru ^b   Hara, Hideaki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cerebral ischemia; Hemorrhagic transformation; Phosphodiesterase 3 inhibitor; Stroke

Indexed keywords

CILOSTAZOL; EVANS BLUE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; EXTRAVASATION; HISTOLOGY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; EVANS BLUE; INDICATORS AND REAGENTS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MICE; NEUROPROTECTIVE AGENTS; TETRAZOLES; TREATMENT OUTCOME;

EID: 60249089819     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.01.039     Document Type: Article

References (21)

1. Aronowski J., Strong R., Shirzadi A., and Grotta J.C. Ethanol plus caffeine (caffeinol) for treatment of ischemic stroke: preclinical experience. Stroke 34 (2003) 1246-1251
2. Brown R.C., and Davis T.P. Calcium modulation of adherens and tight junction function: a potential mechanism for blood-brain barrier disruption after stroke. Stroke 33 (2002) 1706-1711
3. Choi J.M., Shin H.K., Kim K.Y., Lee J.H., and Hong K.W. Neuroprotective effect of cilostazol against focal cerebral ischemia via antiapoptotic action in rats. J. Pharmacol. Exp. Ther. 300 (2002) 787-793
4. Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients, BMJ 324 (2002) 71-86.
5. Hara H., Huang P.L., Panahian N., Fishman M.C., and Moskowitz M.A. Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J. Cereb. Blood Flow Metab. 16 (1996) 605-611
6. Hara H., Friedlander R.M., Gagliardini V., Ayata C., Fink K., Huang Z., Shimizu-Sasamata M., Yuan J., and Moskowitz M.A. Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 2007-2012
7. Kim K.Y., Shin H.K., Choi J.M., and Hong K.W. Inhibition of lipopolysaccharide-induced apoptosis by cilostazol in human umbilical vein endothelial cells. J. Pharmacol. Exp. Ther. 300 (2002) 709-715
8. Kimura Y., Tani T., Kanbe T., and Watanabe K. Effect of cilostazol on platelet aggregation and experimental thrombosis. Arzneimittelforschung 35 (1985) 1144-1149
9. Kohda N., Tani T., Nakayama S., Adachi T., Marukawa K., Ito R., Ishida K., Matsumoto Y., and Kimura Y. Effect of cilostazol, a phosphodiesterase III inhibitor, on experimental thrombosis in the porcine carotid artery. Thromb. Res. 96 (1999) 261-268
10. Lee J.H., Kim K.Y., Lee Y.K., Park S.Y., Kim C.D., Lee W.S., Rhim B.Y., and Hong K.W. Cilostazol prevents focal cerebral ischemic injury by enhancing casein kinase 2 phosphorylation and suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation in rats. J. Pharmacol. Exp. Ther. 308 (2004) 896-903
11. Lee J.H., Lee Y.K., Ishikawa M., Koga K., Fukunaga M., Miyakoda G., Mori T., Hosokawa T., and Hong K.W. Cilostazol reduces brain lesion induced by focal cerebral ischemia in rats-an MRI study. Brain Res. 994 (2003) 91-98
12. Lee J.H., Park S.Y., Shin H.K., Kim C.D., Lee W.S., and Hong K.W. Poly(ADP-ribose) polymerase inhibition by cilostazol is implicated in the neuroprotective effect against focal cerebral ischemic infarct in rat. Brain Res. 1152 (2007) 182-190
13. Lee J.H., Park S.Y., Shin H.K., Kim C.D., Lee W.S., and Hong K.W. Protective effects of cilostazol against transient focal cerebral ischemia and chronic cerebral hypoperfusion injury. CNS Neurosci. Ther. 14 (2008) 143-152
14. Omi H., Okayama N., Shimizu M., Fukutomi T., Nakamura A., Imaeda K., Okouchi M., and Itoh M. Cilostazol inhibits high glucose-mediated endothelial-neutrophil adhesion by decreasing adhesion molecule expression via NO production. Microvasc. Res. 68 (2004) 119-125
15. Park S.Y., Lee J.H., Kim C.D., Lee W.S., Park W.S., Han J., Kwak Y.G., Kim K.Y., and Hong K.W. Cilostazol suppresses superoxide production and expression of adhesion molecules in human endothelial cells via mediation of cAMP-dependent protein kinase-mediated maxi-K channel activation. J. Pharmacol. Exp. Ther. 317 (2006) 1238-1245
16. Park S.Y., Lee J.H., Kim Y.K., Kim C.D., Rhim B.Y., Lee W.S., and Hong K.W. Cilostazol prevents remnant lipoprotein particle-induced monocyte adhesion to endothelial cells by suppression of adhesion molecules and monocyte chemoattractant protein-1 expression via lectin-like receptor for oxidized low-density lipoprotein receptor activation. J. Pharmacol. Exp. Ther. 312 (2005) 1241-1248
17. Qin Z., Karabiyikoglu M., Hua Y., Silbergleit R., He Y., Keep R.F., and Xi G. Hyperbaric oxygen-induced attenuation of hemorrhagic transformation after experimental focal transient cerebral ischemia. Stroke 38 (2007) 1362-1367
18. Tanaka K., Gotoh F., Fukuuchi Y., Amano T., Uematsu D., Kawamura J., Yamawaki T., Itoh N., Obara K., and Muramatsu K. Effects of a selective inhibitor of cyclic AMP phosphodiesterase on the pial microcirculation in feline cerebral ischemia. Stroke 20 (1989) 668-673
19. Tissue plasminogen activator for acute ischemic stroke, The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group, N. Engl. J. Med. 333 (1995) 1581-1587.
20. Wilhite D.B., Comerota A.J., Schmieder F.A., Throm R.C., Gaughan J.P., and Rao A.K. Managing PAD with multiple platelet inhibitors: the effect of combination therapy on bleeding time. J. Vasc. Surg. 38 (2003) 710-713
21. Wakida K., Morimoto N., Shimazawa M., Hozumi I., Nagase H., Inuzuka T., and Hara H. Cilostazol reduces ischemic brain damage partly by inducing metallothionein-1 and -2. Brain Res. 1116 (2006) 187-193