Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain

Blood

Volumn 113, Issue 3, 2009, Pages 696-704

  Mullins, Eric S ^a   Kombrinck, Keith W ^a   Talmage, Kathryn E ^a   Shaw, Maureen A ^a   Witte, David P ^a   Ullman, Joni M ^a   Degen, Sandra J ^a   Sun, William ^a   Flick, Matthew J ^a   Degen, Jay L ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR; POLYINOSINIC POLYCYTIDYLIC ACID; PROTHROMBIN; THROMBIN; INTEGRASE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD CLOTTING; BRAIN HEMORRHAGE; CELL VIABILITY; CONTROLLED STUDY; DISEASE COURSE; ENZYME INDUCTION; GENETIC RECOMBINATION; HEART; HEMOSTASIS; HETEROZYGOSITY; HOMOZYGOSITY; INFLAMMATION; KNOCKOUT GENE; LIFE EXPECTANCY; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; SURVIVAL TIME; THROMBOCYTE FUNCTION; ANIMAL; BRAIN; GENETICS; HEART MUSCLE; METABOLISM; MOUSE MUTANT; NORTHERN BLOTTING; PATHOLOGY;

ANIMALS; BLOOD COAGULATION; BLOTTING, NORTHERN; BRAIN; HEMORRHAGE; INFLAMMATION; INTEGRASES; MICE; MICE, KNOCKOUT; MYOCARDIUM; PERITONITIS; PROTHROMBIN;

EID: 60249083610     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-07-169003     Document Type: Article

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