Design, synthesis and biological evaluation of novel fluorinated docetaxel analogues

European Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2009, Pages 482-491

  Lu, Hong Fu ^a   Sun, Xun ^a   Xu, Liang ^b   Lou, Li Guang ^c   Lin, Guo Qiang ^a,b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cytotoxicity; Docetaxel; Fluorinated docetaxel analogues

Indexed keywords

DOCETAXEL; FLUORINE DERIVATIVE; N DE TERT BUTOXYCARBONYL N [2 (1 DIFLUORO 2 METHYL)PROPYLOXYCARBONYL] 2 DEBENZOYL 2 (3 FLUOROBENZOYL)DOCETAXEL; N DE TERT BUTOXYCARBONYL N [2 (1 FLUORO 2 METHYL)PROPYLOXYCARBONYL] 2 DEBENZOYL 2 (3 FLUOROBENZOYL)DOCETAXEL; N DE TERT BUTOXYCARBONYL N [2 (1 FLUORO 2 METHYL)PROPYLOXYCARBONYL]DOCETAXEL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MALE; MOUSE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORINE; HUMANS; MICE; TAXOIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 60149110347     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.04.004     Document Type: Article

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