ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

Nature

Volumn 457, Issue 7231, 2009, Pages 906-909

  Oshima, Shigeru ^a   Turer, Emre E ^a   Callahan, Joseph A ^a   Chai, Sophia ^a   Advincula, Rommel ^a   Barrera, Julio ^a   Shifrin, Nataliya ^a   Lee, Bettina ^a   Yen, Benjamin ^a   Woo, Tammy ^a   Malynn, Barbara A ^a   Ma, Averil ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABIN 1 PROTEIN; CASPASE 8; FAS ASSOCIATED DEATH DOMAIN PROTEIN; POLYUBIQUITIN; PROTEIN INHIBITOR; TUMOR NECROSIS FACTOR; UBIQUITIN; UNCLASSIFIED DRUG;

APOPTOSIS; CYTOLOGY; EMBRYONIC DEVELOPMENT; INHIBITOR; PROTEIN; SENSOR;

ANEMIA; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL SURVIVAL; EMBRYO; EMBRYO DEVELOPMENT; ENZYME REGULATION; FETUS LIVER; HYPOPLASIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; SENSOR; UBIQUITINATION;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CELL LINE; DNA-BINDING PROTEINS; EMBRYONIC DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JURKAT CELLS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN;

MUS;

EID: 60149104060     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07575     Document Type: Article

References (24)

1. Heyninck, K. et al. The zinc finger protein A20 inhibits TNF-induced NF-κB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-κB-inhibiting protein ABIN-1. J. Cell Biol. 145, 1471-1482 (1999).
2. Opipari, A. W. Jr, Boguski, M. S. & Dixit, V. M. The A20 cDNA induced by tumor necrosis factor α encodes a novel type of zinc finger protein. J. Biol. Chem. 265, 14705-14708 (1990).
3. Doi, T. S. et al. Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality. Proc. Natl Acad. Sci. USA 96, 2994-2999 (1999).
4. Beg, A. A. & Baltimore, D. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274, 782-784 (1996).
5. Wang, C. Y., Mayo, M. W. & Baldwin, A. S. Jr. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-κB. Science 274, 784-787 (1996).
6. Van Antwerp, D. J., Martin, S. J., Kafri, T., Green, D. R. & Verma, I. M. Suppression of TNF-α-induced apoptosis by NF-κB. Science 274, 787-789 (1996).
7. Wullaert, A. et al. Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality. Hepatology 42, 381-389 (2005).
8. Barnhart, B. C., Alappat, E. C. & Peter, M. E. The CD95 type I/type II model. Semin. Immunol. 15, 185-193 (2003).
9. De Smaele, E. et al. Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling. Nature 414, 308-313 (2001).
10. Tang, G. et al. Inhibition of JNK activation through NF-κB target genes. Nature 414, 313-317 (2001).
11. Chang, L. et al. The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIP(L) turnover. Cell 124, 601-613 (2006).
12. Lee, E. G. et al. Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice. Science 289, 2350-2354 (2000).
13. Micheau, O. & Tschopp, J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181-190 (2003).
14. Schneider-Brachert, W. et al. Compartmentalization of TNF receptor 1 signaling: Internalized TNF receptosomes as death signaling vesicles. Immunity 21, 415-428 (2004).
15. Heyninck, K., Kreike, M. M. & Beyaert, R. Structure-function analysis of the A20-binding inhibitor of NF-κ B activation, ABIN-1. FEBS Lett. 536, 135-140 (2003).
16. Ea, C. K., Deng, L., Xia, Z. P., Pineda, G. & Chen, Z. J. Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 22, 245-257 (2006).
17. Wu, C. J., Conze, D. B., Li, T., Srinivasula, S. M. & Ashwell, J. D. Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation. Nature Cell Biol. 8, 398-406 (2006).
18. Wagner, S. et al. Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins. Oncogene 27, 3739-3745 (2008).
19. Deng, L. et al. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103, 351-361 (2000).
20. Wang, C. et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (2001).
21. Chen, Z. J. Ubiquitin signalling in the NF-κB pathway. Nature Cell Biol. 7, 758-765 (2005).
22. Wertz, I. E. & Dixit, V. M. Ubiquitin-mediated regulation of TNFR1 signaling. Cytokine Growth Factor Rev. 19, 313-324 (2008).
23. Lee, J. C. & Peter, M. E. Regulation of apoptosis by ubiquitination. Immunol. Rev. 193, 39-47 (2003).
24. Boone, D. L. et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nature Immunol. 5, 1052-1060 (2004).