Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents

European Journal of Medicinal Chemistry

Volumn 42, Issue 8, 2007, Pages 1151-1157

  Sun, Qing Yan ^a   Zhang, Wan Nian ^a   Xu, Jian Ming ^a   Cao, Yong Bing ^a   Wu, Qiu Ye ^a   Zhang, Da Zhi ^a   Liu, Chao Mei ^a   Yu, Shi Chong ^a   Jiang, Yuan Ying ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antifungal activity; Synthesis; Triazole

Indexed keywords

1 (1H 1,2,4 TRIAZOL 1 YL) 2 (2,4 DIFLUOROPHENYL) 3 [4 [4 [(4 BROMOBENZYLIDENE)AMINO]PHENYL]PIPERAZIN 1 YL]PROPAN 2 OL; 1 (1H 1,2,4 TRIAZOL 1 YL) 2 (2,4 DIFLUOROPHENYL) 3 [4 [4 [(4 CHLOROBENZYLIDENE)AMINO]PHENYL]PIPERAZIN 1 YL]PROPAN 2 OL; 1 (1H 1,2,4 TRIAZOL 1 YL) 2 (2,4 DIFLUOROPHENYL) 3 [4 [4 [(4 FLUOROBENZYLIDENE)AMINO]PHENYL]PIPERAZIN 1 YL]PROPAN 2 OL; 1 (1H 1,2,4 TRIAZOL 1 YL) 2 (2,4 DIFLUOROPHENYL) 3 [4 [4 [(4 HYDROXYBENZYLIDENE)AMINO]PHENYL]PIPERAZIN 1 YL]PROPAN 2 OL; 1 (1H 1,2,4 TRIAZOL 1 YL) 2 (2,4 DIFLUOROPHENYL) 3 [4 [4 [(4 METHYLBENZYLIDENE)AMINO]PHENYL]PIPERAZIN 1 YL]PROPAN 2 OL; 1 (1H 1,2,4 TRIAZOL 1 YL) 2 (2,4 DIFLUOROPHENYL) 3 [4 [4 [(BENZO[1,3]DIOXOL 5 YL METHYLENE)AMINO]PHENYL]PIPERAZIN 1 YL]PROPAN 2 OL; 1 (1H 1,2,4 TRIAZOL 1 YL) 2 (2,4 DIFLUOROPHENYL) 3 [4 [4 [[ 4 (3 CHLOROBENYLOXY)BENZYLIDENE]AMINO]PHENYL]PIPERAZIN 1 YL]PROPAN 2 OL; ANTIFUNGAL AGENT; BENZENE DERIVATIVE; FLUCONAZOLE; FLUORINE DERIVATIVE; ITRACONAZOLE; PIPERAZINE DERIVATIVE; PROPANOL; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TORULOPSIS GLABRATA;

ANTIFUNGAL AGENTS; AZOLES; FUNGI; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PIPERAZINES; PROPANOLS; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34447545691     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.11.003     Document Type: Article

References (12)

1. Fridkin S.K., and Jarvis W.R. Clin. Microbiol. Rev. 9 (1996) 499-511
2. Wingard J.R., and Leather H. Biol. Blood Marrow Transplant. 10 (2004) 73-90
3. Kale P., and Johnson L.B. Drugs Today 41 (2005) 91-105
4. Chandrasekar P.H., and Manavathu E. Drugs Today 37 (2001) 135-148
5. Chen A., and Sobel J.D. Expert Opin. Emerg. Drugs 10 (2005) 21-33
6. Sundriyal S., Sharma R.K., and Jain R. Curr. Med. Chem. 13 (2006) 1321-1335
7. Ji H., Zhang W., Zhou Y., Zhang M., Zhu J., Song Y., and Lu J. J. Med. Chem. 43 (2000) 2493-2505
8. K. Richardson, US Patent 4,404,216, 1983.
9. Yang J., Liu L., Wang X., Lu J., Sun C., Zhang H., Zhou Y., and Zhang Z. Yiyao Gongye 5 (1984) 1-4
10. D.K. Hutchinson, M.R. Barbachyn, S.J. Brickner, R.B. Gammill, M.V. Patel, US Patent 8,804,32, 1996.
11. National Committee for Clinical Laboratory Standards. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Approved standard. Document M27-A2 (2002), National Committee for Clinical Laboratory Standards, Wayne, PA
12. Sun Q., Liu C., Wu Q., Zhang D., Cao Y., Jiang Y., and Zhao H. Zhongguo Yaowu Huaxue Zazhi 14 (2004) 14-18