Immunohistochemical examination of gastrin, gastrin precursors, and gastrin/CCK-2 receptor in human esophageal squamous cell carcinomas

Pathology and Oncology Research

Volumn 14, Issue 4, 2008, Pages 449-455

  Yuan, Aping ^a,b   Liu, Jinzhong ^b   Liu, Yiqing ^b   Bjørnsen, Tone ^c   Varro, Andrea ^d   Cui, Guanglin ^a,b  

^a UNIVERSITY OF TROMSØ   (Norway)

^b ZHENGZHOU UNIVERSITY   (China)

^c UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Esophagus; Gastrin; Immunohistochemistry; Squamous cell carcinoma

Indexed keywords

CHOLECYSTOKININ B RECEPTOR; GASTRIN; GLYCINE; PROGASTRIN;

ADULT; AGED; ARTICLE; CANCER STAGING; CELL DENSITY; CHINA; CLINICAL ARTICLE; CLINICAL EVALUATION; CLINICAL FEATURE; CONTROLLED STUDY; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; HISTOPATHOLOGY; HORMONE SYNTHESIS; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LABORATORY DIAGNOSIS; MALE; PRECURSOR; SEX DIFFERENCE; TISSUE SECTION; TUMOR CELL; TUMOR DIFFERENTIATION; TUMOR GROWTH; TUMOR LOCALIZATION;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; ESOPHAGEAL NEOPLASMS; FEMALE; GASTRINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM STAGING; PROTEIN PRECURSORS; RECEPTOR, CHOLECYSTOKININ B;

EID: 60049095113     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-008-9047-7     Document Type: Article

References (49)

1. Parkin DM, Bray FI, Dcvcsa SS (2001) Cancer burden in the year 2000. The global picture. Eur J Cancer 37(Suppl 8):S4-S66
2. Montesano R, Hollstein M, Hainaut P (1996) Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis: a review. Int J Cancer 69:225-235
3. Zhi H, Wang L, Zhang J et al (2006) Significance of COX-2 expression in human esophageal squamous cell carcinoma. Carcinogenesis 27:1214-1221
4. Imsumran A, Adachi Y, Yamamoto H et al (2007) Insulin-like growth factor-I receptor as a marker for prognosis and a therapeutic target in human esophageal squamous cell carcinoma. Carcinogenesis 28:947-956
5. Sutter AP, Hopfner M, Huether A et al (2006) Targeting the epidermal growth factor receptor by erlotinib (Tarceva) for the treatment of esophageal cancer. Int J Cancer 118:1814-1822
6. Fang MZ, Liu C, Song Y et al (2004) Over-expression of gastrin- releasing peptide in human esophageal squamous cell carcinomas. Carcinogenesis 25:865-871
7. Xie JJ, Xu LY, Zhang HH et al (2005) Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells. Biochem Biophys Res Commun 337:355-362
8. Dockray GJ, Varro A, Dimaline R et al (2001) The gastrins: their production and biological activities. Annu Rev Physiol 63:119-139
9. Ferrand A, Wang TC (2006) Gastrin and cancer: a review. Cancer Lett 238:15-29
10. Aly A, Shulkes A, Baldwin GS (2004) Gastrins, cholecystokinins and gastrointestinal cancer. Biochim Biophys Acta 1704:1-10
11. Takhar AS, Eremin O, Watson SA (2004) The role of gastrin in colorectal carcinogenesis. Surgeon 2:251-257
12. Singh P, Dai B, Wu H et al (2000) Role of autocrine and endocrine gastrin-like peptides in colonic carcinogenesis. Curr Opin Gastroenterol 16:68-77
13. Caplin M, Savage K, Khan K et al (2000) Expression and processing of gastrin in pancreatic adenocarcinoma. Br J Surg 87:1035-1040
14. Rengifo-Cam W, Singh P (2004) Role of progastrins and gastrins and their receptors in GI and pancreatic cancers: targets for treatment. Curr Pharm Des 10:2345-2358
15. Goetze JP, Nielsen FC, Burcharth F et al (2000) Closing the gastrin loop in pancreatic carcinoma: coexpression of gastrin and its receptor in solid human pancreatic adenocarcinoma. Cancer 88:2487-2494
16. Caplin M, Khan K, Savage K et al (1999) Expression and processing of gastrin in hepatocellular carcinoma, fibrolamellar carcinoma and cholangiocarcinoma. J Hepatol 30:519-526
17. Moody TW (2006) Peptide hormones and lung cancer. Panminerva Med 48:19-26
18. Schaer JC, Reubi JC (1999) High gastrin and cholecystokinin (CCK) gene expression in human neuronal, renal, and myogenic stem cell tumors: comparison with CCK-A and CCK-B receptor contents. J Clin Endocrinol Metab 84:233-239
19. Negre F, Fagot-Revurat P, Bouisson M et al (1996) Autocrine stimulation of AR4-2J rat pancreatic tumor cell growth by glycine-extended gastrin. Int J Cancer 66:653-658
20. Hoosein NM, Kiener PA, Curry RC et al (1990) Evidence for autocrine growth stimulation of cultured colon tumor cells by a gastrin/cholecystokinin- like peptide. Exp Cell Res 186:15-21
21. Harris JC, Clarke PA, Awan A et al (2004) An antiapoptotic role for gastrin and the gastrin/CCK-2 receptor in Barrett's esophagus. Cancer Res 64:1915-1919
22. Baldwin GS (1995) The role of gastrin and cholecystokinin in normal and neoplastic gastrointestinal growth. J Gastroenterol Hepatol 10:215-232
23. Seva C, Dickinson CJ, Yamada T (1994) Growth-promoting effects of glycine-extended progastrin. Science 265:410-412
24. Henwood M, Clarke PA, Smith AM et al (2001) Expression of gastrin in developing gastric adenocarcinoma. Br J Surg 88:564- 568
25. Kelly A, Hollande F, Shulkes A et al (1998) Expression of progastrin-derived peptides and gastrin receptors in a panel of gastrointestinal carcinoma cell lines. J Gastroenterol Hepatol 13:208-214
26. Koh TJ, Dockray GJ, Varro A et al (1999) Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. J Clin Invest 103:1119-1126
27. Ottewell PD, Watson AJ, Wang TC et al (2003) Progastrin stimulates murine colonic epithelial mitosis after DNA damage. Gastroenterology 124:1348-1357
28. Singh P, Velasco M, Given R et al (2000) Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen. Gastroenterology 119:162-171
29. Cui G, Koh TJ, Chen D et al (2004) Overexpression of glycine- extended gastrin inhibits parietal cell loss and atrophy in the mouse stomach. Cancer Res 64:8160-8166
30. Moore TC, Jepeal LI, Boylan MO et al (2004) Gastrin stimulates receptor-mediated proliferation of human esophageal adenocarcinoma cells. Regul Pept 120:195-203
31. Van Nieuwenhove Y, De Backer T, Chen D et al (1998) Gastrin stimulates epithelial cell proliferation in the oesophagus of rats. Virchows Arch 432:371-375
32. Karaki Y, Shimazaki K, Okamoto M et al (1996) Effect of endogenous hypergastrinemia on carcinogenesis in the rat esophagus. Surg Today 26:5-11
33. Haigh CR, Attwood SE, Thompson DG et al (2003) Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor. Gastroenterology 124:615-625
34. Abdalla SI, Lao-Sirieix P, Novelli MR et al (2004) Gastrin- induced cyclooxygenase-2 expression in Barrett's carcinogenesis. Clin Cancer Res 10:4784-4792
35. Munoz NDN (1996) Esophageal cancer. In: Schottenfeld D, Fraumeni JF Jr (eds) Cancer epidemiology and prevention. Oxford University Press, New York, pp 681-706
36. Li MX, Cheng SJ (1984) Carcinogenesis of esophageal cancer in Linxian, China. Chin Med J (Engl) 97:311-316
37. Sobin LH, Wittekind CE (2002) UICC TNM classification of malignant tumors, 6th edn. Wiley, New York
38. Varro A, Dockray GJ, Bate GW et al (1997) Gastrin biosynthesis in the antrum of patients with pernicious anemia. Gastroenterology 112:733-741
39. Koh TJ, Field JK, Varro A et al (2004) Glycine-extended gastrin promotes the growth of lung cancer. Cancer Res 64:196-201
40. Tezel E, Nagasaka T, Tezel G et al (2002) Characterization of scattered neuroendocrine cells in ductal carcinoma of the pancreas. Pancreas 25:136-141
41. Ogunwobi OO, Beales IL (2006) Glycine-extended gastrin stimulates proliferation and inhibits apoptosis in colon cancer cells via cyclooxygenase-independent pathways. Regul Pept 134:1-8
42. Harris JC, Gilliam AD, McKenzie AJ et al (2004) The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas. Cancer Res 64:5624-5631
43. Stepan VM, Sawada M, Todisco A et al (1999) Glycine-extended gastrin exerts growth-promoting effects on human colon cancer cells. Mol Med 5:147-159
44. Iwase K, Evers BM, Hellmich MR et al (1997) Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin. Gastroenterology 113:782-790
45. Wang TC, Dockray GJ (1999) Lessons from genetically engineered animal models. I. Physiological studies with gastrin in transgenic mice. Am J Physiol 277:G6-G11
46. Savage K, Waller HA, Stubbs M et al (2006) Targeting of cholecystokinin B/gastrin receptor in colonic, pancreatic and hepatocellular carcinoma cell lines. Int J Oncol 29:1429-1435
47. Van Nieuwenhove Y, Chen D, Willems G (2001) Postprandial cell proliferation in the esophageal epithelium of rats. Regul Pept 97:131-137
48. Poorkhalkali N, Helander HF (2003) Cell kinetics of the oesophageal epithelium in the rat: effects of hypergastrinaemia. Scand J Gastroenterol 38:14-19
49. Singh P, Owlia A, Espeijo R et al (1995) Novel gastrin receptors mediate mitogenic effects of gastrin and processing intermediates of gastrin on Swiss 3T3 fibroblasts. Absence of detectable cholecystokinin (CCK)-A and CCK-B receptors. J Biol Chem 270:8429-8438