Kaempferol, a mutagenic flavonol from Helichrysum simillimum

Human and Experimental Toxicology

Volumn 27, Issue 11, 2008, Pages 845-849

  Elgorashi, E E ^a   Van Heerden, F R ^a   Van Staden, J ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Asteraceae; Helichrysum simillimum; Kaempferol; Mutagenic effect; Salmonella typhimurium TA98

Indexed keywords

KAEMPFEROL;

ARTICLE; BIOASSAY; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FRACTIONATION; HELICHRYSUM; HELICHRYSUM SIMULLINIUM; MUTAGENIC ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SALMONELLA TYPHIMURIUM;

ANIMALS; APOPTOSIS; CELLS, CULTURED; HELICHRYSUM; KAEMPFEROLS; METHANOL; MUTAGENICITY TESTS; MUTAGENS; PLANT EXTRACTS; RATS; SALMONELLA TYPHIMURIUM; SOLVENTS;

ASTERACEAE; HELICHRYSUM; SALMONELLA TYPHIMURIUM;

EID: 59949100296     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327108099532     Document Type: Article

References (37)

1. Barcelos GRM. Shimabukuro F. Mori MP. Maciel MAM. Cólus IMS.. Evaluation of mutagenicity and mutagenicity of cashew stem bark methanolic extract in vitro. J Ethnopharmacol 2007 ; 114: 268-273.
2. Elgorashi EE. Taylor JLS. Maes A. de Kimpe N. van Staden J. Verschaeve L.. The use of plants in traditional medicine: potential genotoxic risks. S Afr J Bot 2002 ; 68: 408-410.
3. Elgorashi EE. Taylor JLS. Maes A. van Staden J. De Kimpe N. Verschaeve L.. Screening of medicinal plants used in South African traditional medicine for genotoxic effects. Toxicol Lett 2003 ; 143: 195-207.
4. Taylor JLS. Elgorashi EE. Maes A. Van Gorp U. De Kimpe N. van Staden J.. Investigating the safety of plants used in South African Traditional medicine: testing for genotoxicity in the micronucleus and alkaline comet assays. Environ Mol Mutagen 2003 ; 42: 144-154.
5. Reid KA. Maes J. Maes A. van Staden J. De Kimpe N. Mulholland DA.. Evaluation of the mutagenic and antimutagenic effects of South African plants. J Ethnopharmacol 2006 ; 106: 44-50.
6. Kassie K. Parzefall W. Musk S. Johnson I. Lamprecht G. Sontag G.. Genotoxic effects of crude juices from Brassica vegetables and juices and extracts from phytopharmaceutical preparations and spices of cruciferous plants origin in bacterial and mammalian cells. Chem Biol Interact 1996 ; 102: 1-16.
7. Schimmer O. Kruger A. Paulini H. Haefele F.. An evaluation of 55 commercial plant extracts in the Ames mutagenicity test. Pharmazie 1994 ; 49: 448-451.
8. Marques RCP. de Medeiros SRB. da Silva Dias C. Barbosa-Filho JM. Agnez-Lima LF.. Evaluation of the mutagenic potential of yangambin and the hydroalcoholoc extract of Octea duckei by the Ames test. Mutat Res 2003 ; 536: 117-120.
9. Asekun OT. Grierson DS. Afolayan AJ.. Characterization of essential oils from Helichrysum odoratissimum using different drying methods. J Appl Sci 2007 ; 7: 1005-1008.
10. Van Vuuren SF. Viljoen AM. van Zyl RL. van Heerden FR. Baser KHC.. The antimicrobial, antimalarial and toxicity profiles of helihumulone, leaf essential oil and extracts of Helichrysum cymosum (L.) D. Don. S Afr J Bot 2006 ; 72: 287-290.
11. Wollenweber E. Steven JF. Ivancic M.. Flavonoids aglycones and a thiophene derivative from Helichrysum cassianum. Phytochemistry 1998 ; 47: 1441-1443.
12. Süzgec S. Meriçli AH. Houghton PJ. Çubukçu B.. Flavonoids of Helichrysum compactum and their antioxidant and antibacterial activity. Fitoterapia 2005 ; 76: 269-272.
13. Mathekga ADM. Meyer JJM. Horn MM. Drewes SE.. An acylated phloroglucinol with antimicrobial properties from Helichrysum caespititium. Phytochemistry 2000 ; 53: 93-96.
14. Rosa A. Deiana M. Atzeri A. Corona G. Incanti A. Melis MP.. Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated β-pyrene-phloroglucinol etherodimer from Helichrysum italicum subsp. Microphyllum. Chem Biol Interac 2007 ; 165: 117-126.
15. Stafford GI. Jäger AK. van Staden J.. Activity of traditional South African sedative and potentially CNS-acting plants in the GABA-benzodiazepine receptor assay. J Ethnopharmacol 2005 ; 100: 210-215.
16. Tepe B. Sokmen M. Akpulat HA. Sokmen A.. In vitro antioxidant activities of the methanol extracts of four Helichrysum species from Turkey. Food Chem 2005 ; 90: 685-689.
17. Aslan M. Orhan DD. Orhan N. Sezik E. Yesilada E.. In vivo antidiabetic and antioxidant potential of Helichrysum plicatum ssp. Plicatums in streptozotocin-induced-diabetic rats. J Ethnopharmacol 2007 ; 109: 54-59.
18. Appendino G. Ottino M. Marquez N. Bianchi F. Giana A. Ballero M.. Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol β-pyrone from Helichrysum italicum ssp. Microphyllum. J Nat Prod 2007 ; 70: 608-612.
19. Lall N. Hussein AA. Meyer JJM.. Antiviral and antituberculous activity of Helichrysum melanacme constituents. Fitoterapia 2006 ; 77: 230-232.
20. Mabry TJ. Markham KR. Thomas MB.. The systematic identification of Flavonoids. New York: Springer-Verlag ; 1970.
21. Maron DM. Ames BN.. Revised method for the Salmonella mutagenicity test. Mutat Res 1983 ; 113: 173-215.
22. Niering P. Michels G. Wätjen W. Ohler S. Steffan B. Chovolou Y.. Protective and detrimental effects of kaempferol in rat H4IIE cells: Implication of oxidative stress and apoptosis. Toxicol Appl Pharmacol 2005 ; 209: 114-122.
23. Ohran I. Küpeli E. Terzioäÿlu S. Yesilada E.. Bioassay-guided isolation of kaempferol-3-O-α-D-galactoside with anti-inflammtory and antinociceptive activity from the aerial part of Calluna vulgaris. J Ethnopharmacol 2007 ; 114: 32-37.
24. Anderson D. Dobryåska MM. Baåÿaran N. Baåÿaran A. Yu T-W.. Flavonoids modulate comet assay responses to food mutagens in human lymphocytes and sperms. Mutat Res 1998 ; 402: 269-277.
25. Cea GFA. Etcheberry KFC. Dulout FN.. Induction of micronuclei in mouse bone-marrow cells by the flavonoid 5,3',4'trihydroxy-3,6,7,8-tetramethoxyflavone (THTMF). Mutat Res 1983 ; 119: 339-342.
26. Carver JH. Carrano AV. MacGreger JT.. Genetic effects of the flavonols quercetin, kaempferol, and galangin on Chinese hamster ovary cells. Mutat Res 1983 ; 113: 45-60.
27. Choi JS. Park KY. Moon SH. Rhee SH. Young HS.. Antimutagenic effect of plant flavonoids in the Salmonella assay system. Arch Pharmacal Res 1994 ; 17: 71-75.
28. Edenharder R. Grünhage D.. Free radical scavenging abilityies of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA 102. Mutat Res 2003 ; 540: 1-18.
29. Ogawa S. Hirayama T. Sumida Y.. Enhancement of the mutagenicity of 2-acetylaminofuorene by flavonoids and the structural requirements. Mutat Res 1987 ; 190: 107-112.
30. Krizkoyá L. Nagy M. Polónyi J. Ebringer L.. The effect of flavonoids on ofloxacin-induced mutagenicity in Euglena gracilis. Mutat Res 1998 ; 416: 85-92.
31. Ruf AA. Webb J. Anderson D.. Modulation by flavonoids of the effects of a food mutagen in different thalassaemia genotypes in the comet assay. Teratog Carcinog Mutagen 2003 ; (Suppl. 2): 93-102.
32. Dobrzyåska MM. Baumgartner A. Anderson D.. Antioxidants modulate thyroid hormone- and noradrenaline- induced DNA damage in human sperm. Mutagenesis 2004 ; 19: 325-330.
33. Leung HW-C. Lin C-J. Hour M-J. Yang W-H. Wang M-Y. Lee H-Z.. Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes. Food Chem Toxicol 2007 ; 45: 2005-2013.
34. Sharma V. Joseph C. Ghosh S. Agarwal A. Mishra MK. Sen E.. Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Mol Cancer Therap 2007 ; 6: 2544-2553.
35. Seung MO. Yeon PK. Kyu HC.. Biphasic effects of kaempferol on the estrogenicity in human breast cancer cells. Arch Pharmacal Res 2006 ; 29: 354-362.
36. Kim J-D. Liu L. Guo W. Meydani M.. Chemical structure of flavonols in relation to modulation of angiogenesis and immune-endothelial cell adhesion. J Nutr Biochem 2006 ; 17: 165-176.
37. Hoensch HP. Kirch W.. Potential role of flavonoids in the prevention of intestinal neoplasia: a review of their mode of action and their clinical perspective. Int J Gastrointesl Cancer 2005 ; 35: 187-196.