Activity of traditional South African sedative and potentially CNS-acting plants in the GABA-benzodiazepine receptor assay

Journal of Ethnopharmacology

Volumn 100, Issue 1-2, 2005, Pages 210-215

  Stafford, Gary I ^a   Jäger, Anna K ^b   Van Staden, Johannes ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Binding assay; GABA; Sedation; Traditional medicine

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ACASIA SIEBERIANA EXTRACT; ACASIA XANTHOPHLOEA EXTRACT; ARCTOPUS ECHINATUS EXTRACT; ARTEMISIA AFRA EXTRACT; BENZODIAZEPINE RECEPTOR; BERKHEYA BERGIANA EXTRACT; BERKHEYA MONTANA EXTRACT; BERKHEYA RHAPONTICA EXTRACT; CATHA EDULIS EXTRACT; COTYLEDON ORBICULATA EXTRACT; CROTON SYLVATICUS EXTRACT; DIOSCOREA DREGEANA EXTRACT; FLUMAZENIL; GOMPHOCARPUS PHYSOCARPUS EXTRACT; HELICHRYSUM ARGYROLEPIS EXTRACT; HELICHRYSUM HESBACEUM EXTRACT; HELICHRYSUM NUDIFOLIUM EXTRACT; HELICHRYSUM RUGULOSUM EXTRACT; HELICHRYSUM SIMILLIMUM EXTRACT; HELICHRYSUM UMBRACULIGERUM EXTRACT; HELICHYSUM RUDERALE EXTRACT; MENTHA AQUATICA EXTRACT; MILLETTIA GRANDIS EXTRACT; PLANT EXTRACT; SCADOXUS PUNICEUS EXTRACT; SEDATIVE AGENT; TRITIUM; UNCLASSIFIED DRUG; UNINDEXED DRUG; XYSMALOBIUM UNDULATUM EXTRACT;

ACACIA SIEBERIANA; AGAPANTHUS CAMPANULATUS; AGAPANTHUS PRAECOX; ANIMAL TISSUE; ARCTOPUS ECHINATUS; ARTEMISA AFRA; ARTICLE; ASSAY; BERKHEYA BERGIANA; BERKHEYA MONTANA; BERKHEYA RHAPONTICA; BINDING ASSAY; CATHA EDULIS; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASE; CINNAMOMUM COMPHORA; CONTROLLED STUDY; CONVULSION; COTYLEDON ORBICULATA; CROTON SYLVATICUS; DATURA FEROX; DATURA STRAMONIUM; DIOSCOREA DREGEANA; DOSE RESPONSE; DRUG RECEPTOR BINDING; EPILEPSY; EXOTIC SPECIES; GOMPHOCARPUS PHYSOCARPUS; HELICHRYSUM; HELICHRYSUM ARGYROLEPSIS; HELICHRYSUM HESBACEUM; HELICHRYSUM NUDIFOLIUM; HELICHRYSUM RUDERALE; HELICHRYSUM RUGULOSUM; HELICHRYSUM SIMILLIMUM; HELICHRYSUM UMBRACULIGERUM; MALVA PARVIFLORA; MEDICINAL PLANT; MENTHA AQUATICA; MENTHA LONGIFOLIA; MILLETTIA SUTHERLANDII; NATIVE SPECIES; NONHUMAN; PIPER CAPENSE; PLANT LEAF; POKEWEED; RAT; SCADOXUS PRUNICEUS; SCHOTIA BRACHYPETALA; SEDATION; SOUTH AFRICA; TRADITIONAL MEDICINE; XYSMALOBIUM UNDULATUM;

ANIMALS; CENTRAL NERVOUS SYSTEM AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPNOTICS AND SEDATIVES; MEDICINE, AFRICAN TRADITIONAL; PLANT BARK; PLANT EXTRACTS; PLANT LEAVES; PLANT ROOTS; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA; SEEDS; SOUTH AFRICA;

ARCTOPUS ECHINATUS; HELICHRYSUM; MENTHA AQUATICA;

EID: 23044483761     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2005.04.004     Document Type: Article

References (24)

1. Z. Burzanska-Hermann, H. Rzadkowska-Bodalska, and W. Olechnowicz-Stepien Isolation and identification of flavonoid compounds of Mentha aquatica L. herb Roczniki Chemii 51 1977 701 709
2. A/benzodiazepine Receptor as Target for Psychoactive Drugs 1996 Springer-Verlag Heidelberg, Germany
3. M. Gelfand, S. Mavi, R.B. Drummond, and B. Ndemera The Traditional Medical Practitioner in Zimbabwe 1985 Mambo Press Zimbabwe
4. P. Goldblatt An analysis of the flora of southern Africa: its characterisation, relationships and origins Ann. Missouri Bot. Gardens 65 1978 369 436
5. A. Hutchings, A.H. Scott, G. Lewis, and A.B. Cunningham Zulu Medicinal Plants: An Inventory 1996 University of Natal Press Pietermaritzburg
6. M.W. Iwu Handbook of African Medicinal Plants 1993 CRC Press
7. A.K. Jäger, S.P. Mohoto, F.R. van Heerden, and A.M. Viljoen Activity of a traditional South African epilepsy remedy in the GABA-benzodiazepine receptor assay Journal of Ethnopharmacology 96 2005 603 606
8. A receptor Journal of Medicinal Chemistry 45 2002 4188 4201
9. A.D.M. Mathekga, J.J.M. Meyer, M.M. Horn, and S.E. Drewes An acylated phloroglucinol with anti-microbial properties from Helichrysum caespititium Phytochemistry 53 2000 93 96
10. E. Palmer, and N. Pitman Trees of Southern Africa vol. 2 1972 Cape Town Balkema
11. J. Pujol Natur Africa: The Herbalists Handbook 1990 Jean Pujol Natural Healers Foundation Durban
12. S.M. Salah, and A.K. Jäger Screening of traditionally used Lebanese herbs for neurological activities Journal of Ethnopharmacology 97 2005 145 149
13. M. Sayyah, L. Nadjafnia, and M. Kamalinejad Anti-convulsant activity and chemical composition of Artemisia dracunculus L. essential oil Journal of Ethnopharmacology 94 2004 283 287
14. T.L. Shale, W.A. Stirk, and J. van Staden Screening of medicinal plants used in Lesotho for anti-bacterial and anti-inflammatory activity Journal of Ethnopharmacology 67 1999 347 354
15. J.F. Sobiecki A preliminary inventory of plants used for psychoactive purposes in southern Africa healing traditions Trans. R. Soc. South Africa 57 2002 1 24
16. C.R. Swift, and T. Asuni Mental Health and Disease in Africa 1975 Churchill Livingston Edinburgh
17. A-benzodiazepine receptor assay Journal of Ethnopharmacology 93 2004 177 182
18. B.-E. Van Wyk, and N. Gericke Peoples Plants: A Guide to Useful Plants of Southern Africa 2000 Briza Publications Pretoria
19. B.-E. Van Wyk, B. van Oudtshoorn, and N. Gericke Medicinal Plants of South Africa 1997 Briza Publications Pretoria
20. D.J.H. Veale, K.I. Furman, and D.W. Oliver South African traditional herbal medicines used during pregnancy and child-birth Journal of Ethnopharmacology 36 1992 185 191
21. J.M. Watt African plants potentially useful in mental health Lloydia 30 1967 1 22
22. J.M. Watt, and M.G. Breyer-Brandwijk The Medicinal and Poisonous Plants of Southern and Eastern Africa second ed. 1962 Livingston London
23. E. Williamson, and F.J. Evans Potter's New Cyclopaedia of Botanical Drugs and Preparations 1988 Saffron Walden England
24. E. Wollenweber, and M. Jay Flavones and flavonols J.B. Harborne The Flavonoids: Advances in Research Since 1980 1988 Chapham & Hall London