Actinomycin D identified as an inhibitor of discoidin domain receptor 2 interaction with collagen through an insect cell based screening of a drug compound library

Biological and Pharmaceutical Bulletin

Volumn 32, Issue 1, 2009, Pages 136-141

  Siddiqui, Kauser ^a   Kim, Geun Woong ^a   Lee, Dong Hoon ^a   Shin, Hae Ryun ^a   Yang, Eun Gyeong ^a   Lee, Nam Taek ^b   Yang, Beom Seok ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea Military Academy   (South Korea)

Author keywords

Actinomycin D; Collagen; Discoidin domain receptor 2; Inhibitor; Insect cell; Screening

Indexed keywords

CELL SURFACE RECEPTOR; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 3; COLLAGEN TYPE 4; COLLAGEN TYPE 5; DACTINOMYCIN; DISCOIDIN DOMAIN RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBRONECTIN; GELATIN; INSULIN RECEPTOR; LAMININ; PROTEIN TYROSINE KINASE; TRITON X 100; TUNICAMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CELL ADHESION; CELL GROWTH; CELL MEMBRANE; CELL MIGRATION; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENETIC TRANSFECTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSECT CELL; MICROSCOPY; NEOPLASM; NONHUMAN; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-BACTERIAL AGENTS; CELL LINE, TRANSFORMED; COLLAGEN TYPE I; DACTINOMYCIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION; HUMANS; IMMUNOPRECIPITATION; INSECTS; PEPTIDE LIBRARY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, MITOGEN; RECOMBINANT PROTEINS; TRANSFECTION; TUNICAMYCIN;

EID: 59949089046     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.32.136     Document Type: Article

References (27)

1. Johnson J. D., Edman J. C., Rutter W. J., Proc. Natl. Acad. Sci. U.S.A., 15, 5677-5681 (1993).
2. Alves F., Vogel W., Mossie K., Millauer B., Höfler H., Ullrich A., Oncogene, 10, 609-618 (1995).
3. Vogel W., Gish G. D., Alves F., Pawson T., Mol. Cell, 1, 13-23 (1997).
4. Shrivastava A., Radziejewski C., Campbell E., Kovac L., McGlynn M., Ryan T. E., Davis S., Goldfarb M. P., Glass D. J., Lemke G., Yancopoulos G. D., Mol. Cell, 1, 25-34 (1997).
5. Alves F., Saupe S., Ledwon M., Schaub F., Hiddemann W., Vogel W. F., FASEB J., 15, 1321-1323 (2001).
6. Leitinger B., Kwan A. P., Matrix Biol., 25, 355-364 (2006).
7. Curat C. A., Eck M., Dervillez X., Vogel W. F., J. Biol. Chem., 276, 45952-45958 (2001).
8. Leitinger B., J. Biol. Chem., 278, 16761-16769 (2003).
9. Abdulhussein R., McFadden C., Fuentes-Prior P., Vogel W. F., J. Biol. Chem., 279, 31462-31470 (2004).
10. Olaso E., Labrador J. P., Wang L., Ikeda K., Eng F. J., Klein R., Lovett D. H., Lin H. C., Friedman S. L., J. Biol. Chem., 277, 3606-3613 (2002).
11. Renne C., Willenbrock K., Kuppers R., Hansmann M. L., Brauninger A., Blood, 105, 4051-4059 (2005).
12. Chua H. H., Yeh T. H., Wang Y. P., Huang Y. T., Sheen T. S., Lo Y. C., Chou Y. C., Tsai C. H., Head Neck, 30, 427-436 (2008).
13. Evtimova V., Zeillinger R., Weidle U. H., Tumour Biol., 24, 189-198 (2003).
14. Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J. M., Yuan J., Bakalarski C. E., Villen J., Kornhauser J. M., Smith B., Li D., Zhou X., Gygi S. P., Gu T. L., Polakiewicz R. D., Rush J., Comb M. J., Cell, 131, 1190-1203 (2007).
15. Olaso E., Ikeda K., Eng F. J., Xu L., Wang L. H., Lin H. C., Friedman S. L., J. Clin. Invest., 108, 1369-1378 (2001).
16. Xu L., Peng H., Wu D., Hu K., Goldring M. B., Olsen B. R., Li Y., J. Biol. Chem., 280, 548-555 (2005).
17. Wang J., Lü H., Liu X., Deng Y., Sun T., Li F., Ji S., Nie X., Yao L., J. Autoimmun., 19, 161-168 (2002).
18. Waring M. J., Annu. Rev. Biochem., 50, 159-192 (1981).
19. Goldberg I. H., Beerman T. A., Poon R., "Cancer: A Comprehensive Treatise," Plenum Publishing Corp., New York, 1977, pp. 427-456.
20. Goldberg I. H., Friedman P. A., Annu. Rev. Biochem., 40, 775-810 (1971).
21. Yang K., Kim J. H., Kim H. J., Park I. S., Kim I. Y., Yang B. S., J. Biol. Chem., 280, 39058-39066 (2005).
22. Takara K., Sakaed T., Yagami T., Kobayamashi H., Ohmoto N., Horinouchi M., Nishiguchi N., Okumura K., Biol. Pharm. Bull., 25, 771-778 (2002).
23. Said E. A., John L., Martin G., J. Neurooncol., 31, 195-207 (1997).
24. Zhimin T., Jerry G., Harvey S. P., Souid A. K., Mol. Pharm., 4, 583-595 (2007).
25. Gniazdowski M., Denny W. A., Nelson S. M., Czyz M., Curr. Med. Chem., 10, 909-924 (2003).
26. Markasz L., Kis L. L., Stuber G., Flaberg E., Otvos R., Eksborg S., Skribek H., Olah E., Szekely L., Leuk. Lymphoma, 48, 1835-1845 (2007).
27. Ichikawa O., Osawa M., Nishida N., Goshima N., Nomura N., Shimada I., EMBO J., 26, 4168-4176 (2007).