Sheng-Mai-San reduces adriamycin-induced cardiomyopathy in rats

American Journal of Chinese Medicine

Volumn 34, Issue 2, 2006, Pages 295-305

  You, Jyh Sheng ^a,c   Huang, Hui Feng ^d   Chang, Ying Ling ^a   Lee, Ying Shiung ^b,c  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b Section of Cardiology   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Adriamycin; Antioxidation; Cardiomyopathy; Sheng Mai San; Traditional Chinese medicine

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; CHINESE DRUG; DNA; DOXORUBICIN; FREE RADICAL; GINSENG EXTRACT; GLUTATHIONE PEROXIDASE; HERBACEOUS AGENT; LIPID; NUCLEIC ACID; OPHIOPOGON ROOT; RNA; SCHISANDRA EXTRACT; SHENG MAI SAN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCITES; CARDIOMYOPATHY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG DOSE REGIMEN; ELECTRON MICROSCOPY; ENZYME INHIBITION; ENZYME SYNTHESIS; FEEDING APPARATUS; HEART DISEASE; HEART MUSCLE; HEART MUSCLE INJURY; HEART PROTECTION; LIPID PEROXIDATION; LIVER CONGESTION; MACROMOLECULE; MALE; MORTALITY; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RAT; RAT STRAIN; RNA SYNTHESIS; SCHISANDRACEAE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARDIOMYOPATHIES; CARDIOTONIC AGENTS; DNA; DOXORUBICIN; DRUG COMBINATIONS; DRUGS, CHINESE HERBAL; GLUTATHIONE PEROXIDASE; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MICROSCOPY, ELECTRON; RATS; RATS, WISTAR; RNA; SUPEROXIDE DISMUTASE;

EID: 33645090422     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X06003849     Document Type: Article

References (26)

1. Cheng, J.T. Review: Drug therapy in Chinese traditional medicine. J. Clin. Pharmacol. 40: 445-450, 2000.
2. Gewitz, D.A. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem. Pharmacol. 57: 727-741, 1999.
3. Ichikawa, H. and T. Konishi. In vitro antioxidant potentials of traditional Chinese medicine, Shengmai San and their relation to in vivo protective effect on cerebral oxidative damage in rats. Biol. Pharm. Bull. 25: 898-903, 2002.
4. Ichikawa, H., X. Wang and T. Konishi. Role of component herbs in antioxidant activity of shengmai san a traditional Chinese medicine formula preventing cerebral oxidative damage in rat. Am. J. Chin. Med. 31(4): 509-521, 2003.
5. Ko, K.M., P.K. Yick, M.K.T. Poon, C.T. Che, K.H. Ng and Y. C. Kong. Schisandra chinensis derived antioxidant activities in Sheng-Mai-San, a compound formulation, in vivo and in vitro. Phytother. Res. 9: 203-206, 1995.
6. Kumar, D., L.A. Kirshenbaum, T. Li, I. Danelisen and P.K. Singal. Apoptosis in adriamycin caradiomyopathy and its modulation by probucol. Antioxid. Redox Signal. 3: 135-145, 2001.
7. Li, P.C., K.T. Poon and K.M. Ko. Schisandra chinensis-dependent myocardial protective action of Sheng-Mai-San in rats. Am. J. Chin. Med. 24: 255-262, 1996.
8. Li, T., I. Danelisen, A. Bello-Klein and P. K. Singal. Effects of probucol on changes of antioxidant enzymes in adriamycin-induced cardiomyopathy in rats. Cardiovasc. Res. 46: 523-530, 2000.
9. Lu, B.J., Y.Z. Rong and M.H. Zhao. Effects of sheng-mai san on lipid peroxidation in acute myocardial infarction patients. Chung-Kuo Chung His i Chieh Ho Tsa Chih 14(12): 712-714, 1994.
10. Monti, E., E. Prosperi, R. Supino and G. Bottiroli. Free radical-dependent DNA lesions are involved in the delayed cardiotoxicity induced by adriamycin in the rat. Anticancer Res. 15: 193-197, 1995.
11. Morishima, I., H. Matsui and H. Mukawa. Melatonin, a pineal hormone with antioxidant property, protects against adriamycin cardiomyopathy in rats. Life Sci. 63: 511-521, 1998.
12. Rabelo, E., K.D.E. Angelis, P. Bock, T.G. Fernandes, F. Cervo, A.B. Klein, N. Clausell and M.C. Irigoyen. Barorelfex sensitivity and oxidative stress in adriamycin-induced heart failure. Hypertension 38: 576-580, 2001.
13. Rong, T., W.H. Wen, M. Yao and Y.S. Han. Role of oxygen radical in myocardial reoxygenation injury and the protective effect of Sheng-Mai-San. J. Shanghai Second Med. School 3: 15, 1988.
14. Singal, P.K., C.M.R. Deally and L.E. Weinberg. Subcellular effects of adriamycin in the heart: A concise review. J. Mol. Cell. Cardiol. 19: 817-828, 1987.
15. Singal, P.K., N. Khaper, V. Palace and D. Kumar. The role of oxidative stress in the genesis of heart disease. Cardiovasc. Res. 40: 426-432, 1998.
16. Singal, P.K. and N. Siveski-Iliskovic. Doxorubicin-induced cardiomypathy. N. Engl. J. Med. 339: 900-905, 1998.
17. Siveski-Iliskovic, N., N. Kaul and P.K. Singal. Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats. Circulation 89: 2829-2835, 1994.
18. Steinhertz, L.J., P.G. Steinhertz., C.T.C. Tan, G. Heller and L. Murphy. Cardiac toxicity 4 to 20 years after completing anthracycline therapy. J. Am. Med. Assoc. 266: 1672-1677, 1991.
19. Van Acker, S.A.B.E., K. Kramer, E.E. Voest, J.A. Grimbergen, J. Zhang, W.J.F. Van der Vijgh and A. Bast. Doxorubicin-induced cardiotoxicity monitored by ECG in freely moving mice. Cancer Chemother. Pharmacol. 38: 95-101, 1996.
20. Wang, J., Z. Wang and G. Tang. TCM treatment of extrasystole with huanglian shengmai yin - a report of 357 cases. J. Tradit. Chin. Med. 23: 35-37, 2003.
21. ATP channels. Circ. J. 66(8 : 763-768, 2002.
22. ATP channel. Am. J. Chin. Med. 29: 367-375, 2001.
23. Wang, X.J., T. Magara and T. Konishi. Prevention and repair of cerebral ischemia-reperfusion injury by Chinese herbal medicine, Shengmai San, in rats. Free Radic. Res. 31: 449-455, 1999.
24. Wu, S., Y.S. Ko, M.S. Teng, Y.L. Ko, L.A. Hsu, C. Hsueh, Y.Y. Chou, C.C. Liew and Y.S. Lee. Adriamycin-induced cardiomycyte and endothelial cell apoptosis: In Vitro and In Vivo studies. J. Mol. Cell. Cardiol. 34: 1595-1607, 2002.
25. You, J.S., H.F. Huang and D.M. Hau. Effects of Xuefu-zhuyu-tang and mitomycin C on liver tumor in mice. Chang Gung Med. J. 26: 417-424, 2003.
26. You, J.S., I.H. Lin, Y.L. Ko, C.W. Chian, Y.C. Hung and Y.S. Lee. Therapeutic effects of Sheng-mai-san in patients with congestive heart failure: A preliminary study. Chin. Med. J. 5: 2001 (http://www.cmj.org).