Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming

Journal of Ethnopharmacology

Volumn 122, Issue 1, 2009, Pages 28-34

  Kuo, Yao Haur ^a   Tsai, Wei Jern ^a   Loke, Soy Hwee ^a   Wu, Tian Shung ^a   Chiou, Wen Fei ^a  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Astragalus membranaceus; Chronic fatigue; Cytokines; Endurance; Splenocyte proliferation

Indexed keywords

CYTOKINE; FLAVONOID; FORMONONETIN; INTERLEUKIN 2; INTERLEUKIN 4; ISOFLAVONE DERIVATIVE; NORHOMOPTEROCARPIN; ONONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTRAGALUS MEMBRANACEUS; BODY WEIGHT; CELL CULTURE; CELL PROLIFERATION; CHRONIC FATIGUE SYNDROME; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DIET RESTRICTION; DRUG EFFICACY; DRUG STRUCTURE; ENDURANCE; FORCED SWIMMING TEST; IMMUNE SYSTEM; IMMUNOMODULATION; IMMUNOREGULATION; MALE; NONHUMAN; RAT; SPLEEN; SPLEEN CELL; SPLEEN WEIGHT; SPRAGUE DAWLEY RAT; TH1 CELL; TH2 CELL;

ANIMALS; ASTRAGALUS MEMBRANACEUS; BODY WEIGHT; CALORIC RESTRICTION; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FATIGUE SYNDROME, CHRONIC; IMMUNOLOGIC FACTORS; INTERLEUKIN-2; INTERLEUKIN-4; ISOFLAVONES; MALE; ORGAN SIZE; PHYSICAL ENDURANCE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN; SWIMMING;

ASTRAGALUS MEMBRANACEUS; RATTUS;

EID: 59849128091     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.11.025     Document Type: Article

References (46)

1. Asha Devi S., Prathima S., and Subramanyam M.V. Dietary vitamin E and physical exercise: I. Altered endurance capacity and plasma lipid profile in ageing rats. Experimental Gerontology 38 (2003) 285-290
2. Bedir E., Pugh N., Calis I., Pasco D.S., and Khan I.A. Immunostimulatory effects of cycloartane-type triterpene glycosides from Astragalus species. Biological and Pharmaceutical Bulletin 23 (2000) 834-837
3. Brutsaert T.D., Hernandez-Cordero S., Rivera J., Viola T., Hughes H., and Haas J.D. Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, nonanemic women. The American Journal of Clinical Nutrition 77 (2003) 441-448
4. Buchwald D., Cheney P.R., Peterson D.L., Henry B., Wormsley S.B., Geiger A., Ablashi D.V., Salahuddin S.Z., Saxinger C., Biddle R., Kikinis R., Jolesz F.A., Folks T., Balachandran N., Peter J.B., Gallo R.C., and Komaroff A.L. A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection. Annals of Internal Medicine 116 (1992) 103-113
5. Chang H., and But P. Pharmacology and Applications of Chinese Materia Medica (1987), World Scientific, Singapore p. 1041
6. Chao C.C., Janoff E.N., Hu S., Thomas T.W., Gallagher M., Tsang M., and Peterson P.K. Altered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome. Cytokine 3 (1991) 292-298
7. Cheney P.R., Dorman S.E., and Bell D.S. Interleukin-2 and the chronic fatigue syndrome. Annals of Internal Medicine 110 (1989) 321
8. Cui R., He J.C., Wang B., Zhang F., Chen G.Y., Yin S., and Shen H. Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats. Cancer Chemotherapy and Pharmacology 51 (2003) 75-80
9. Dawson C.A., Nadel E., and Hovarth S.M. Cardiac output in the cold stressed swimming rats. American Journal of Physiology 214 (1968) 320-325
10. Finaud J., Lac G., and Filaire E. Oxidative stress: relationship with exercise and training. Sports Medicine 36 (2006) 327-358
11. Fukuda K., Straus S., Hickie I., Sharpe M.C., Dobbins J.G., and Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Annals of Internal Medicine 121 (1994) 953-959
12. Gold D., Bowden R., Sixbey J., Riggs R., Katon W.J., Ashley R., Obrigewitch R.M., and Corey L. Chronic fatigue. A prospective clinical and virologic study. The Journal of the American Medical Association 264 (1990) 48-53
13. Goshorn R.K. Chronic fatigue syndrome. Seminars in Neurology 18 (1998) 237-242
14. Harada S., Ping L., Obara T., Oikawa H., Miyata M., Matsuo M., et al. The antitumor effect of hyperthermia combined with fluorouracil and its analogues. Radiation Res 142 (1995) 232-241
15. Huang G.C., Wu L.S., Chen L.G., Yang L.L., and Wang C.C. Immuno-enhancement effects of Huang Qi Liu Yi Tang in a murine model of cyclophosphamide-induced leucopenia. Journal of Ethnopharmacology 109 (2007) 229-235
16. Jia Z., Tang M., and Wu J. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chemistry 64 (1999) 555-559
17. Klimas N.G., Salvato F.R., Morgan R., and Fletcher M.A. Immunologic abnormalities in chronic fatigue syndrome. Journal of Clinical Microbiology 28 (1990) 1403-1410
18. Landay A.L., Jessop C., Lennette E.T., and Levy J.A. Chronic fatigue syndrome: clinical condition associated with immune activation. Lancet 338 (1991) 707-712
19. Lee K.Y., and Jeon Y.J. Macrophage activation by polysaccharide isolated from Astragalus membranaceus. International Immunopharmacology 5 (2005) 1225-1233
20. Lee J.C., Lim K.T., and Jang Y.S. Identification of Rhus verniciflua Stokes compounds that exhibit free radical scavenging and anti-apoptotic properties. Biochimica et Biophysica Acta 1570 (2002) 181-191
21. Lin L.Z., He X.G., Lindenmaier M., Nolan G., Yang J., Cleary M., Qiu S.X., and Cordell G.A. Liquid chromatography-electrospray ionization mass spectrometry study of the flavonoids of the roots of Astragalus mongholicus and Astragalus membranaceus. Journal of Chromatography 876 (2000) 87-95
22. Linde A., Andersson B., Svenson S.B., Ahrne H., Carlsson M., Forsberg P., Hugo H., Karstorp A., Lenkei R., Lindwall A., Loftenius A., Sall C., and Andersson J. Serum levels of lymphokines and soluble cellular receptors in primary Epstein-Barr virus infection and in patients with chronic fatigue syndrome. Journal of Infectious Diseases 165 (1992) 994-1000
23. Lloyd A., Hickie I., Hickie C., Dwyer J., and Wakefield D. Cell-mediated immunity in patients with chronic fatigue syndrome, healthy control subjects and patients with major depression. Clinical and Experimental Immunology 87 (1992) 76-79
24. Lucey D.R., Clerici M., and Shearer G.M. Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases. Clinical Microbiological Reviews 9 (1996) 532-562
25. Lyall M., Peakman M., and Wessely S. A systematic review and critical evaluation of the immunology of chronic fatigue syndrome. Journal of Psychosomatic Research 55 (2003) 79-90
26. Ma X.Q., Shi Q., Duan J.A., Dong T.T.X., and Tsim K.W.K. Chemical analysis of Radix Astragali (Huangqi) in China: a comparison with its adulterants and seasonal variations. Journal of Agriculture and Food Chemistry 50 (2002) 4861-4866
27. Mckenna D.J., Hughes K., and Jones K. Astragalus. Alternative Therapeutic Health Medicine 8 (2002) 34-40
28. Metz G.A.S., Schwabb M.E., and Welzl H. The effects of acute and chronic stress on motor and sensory performance in male Lewis rats. Physiology and Behavior 72 (2001) 29-35
29. Mosmann T.R., and Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunology Today 17 (1996) 138-146
30. Park J., Kim S.H., Cho D., and Kim T.S. Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity. Immunology 116 (2005) 71-81
31. Rabinovitch A. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation. Diabetes 43 (1994) 613-621
32. Rapoport M.J., Mor A., Vardi P., Ramot Y., Winker R., Hindi A., and Bistritzer T. Decreased secretion of Th2 cytokines proceeds up-regulated and delayed secretion of Th1 cytokines in activated peripheral blood mononuclear cells from patients with insulin-dependent diabetes mellitus. Journal of Autoimmunity 11 (1998) 635-642
33. Shao B.M., Xu W., Dai H., Yu P., Li Z., and Gao X.M. A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochemical and Biophysical Research Communication 320 (2004) 1103-1111
34. Sinclair S. Chinese herbs: a clinical review of Astragalus, Ligusticum, and Schizandrae. Alternative Medicine Review 3 (1998) 338-344
35. Sun J.L., Hu Y.L., Wang D.Y., Zhang B.K., and Liu J.G. Immunologic enhancement of compound Chinese herbal medicinal ingredients and their efficacy comparison with compound Chinese herbal medicines. Vaccine 24 (2006) 2343-2348
36. Takao K., Nagatani T., Kitamura Y., Kawasaki K., Hayakawa H., and Yamawaki S. Chronic forced swim stress of rats increases frontal cortical 5-HT2 receptors and the wet-dog shakes they mediate, but not frontal cortical β-adrenoceptors. European Journal of Pharmacology 294 (1995) 721-726
37. Tang W., and Eisenbrand G. Chinese Drugs of Plant Origin Chemistry, Pharmacology and Use in Traditional and Modern Medicine (1992), Springer-Verlag, Berlin pp. 191
38. Ueda H., Yamazaki C., and Yamazaki M. A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-α production. Bioscience, Biotechnology and Biochemistry 68 (2004) 119-125
39. Upton R., and Petrone C. American Herbal Pharmacopoeia and Therapeutic Compendium, Astragalus Root, Astragalus membranaceus and Astragalus membranaceus var. mon-gholicus, Analytical, Quality Control, and Therapeutic Monograph (1999), American Herbal Pharmacopoeia, Santa Cruz, CA
40. Verotta L., Guerrini M., El-Sebakhy N.A., Asaad A.M., Toaima S.M., Abou-Sheer M.E., Luo Y.D., and Pezzuto J.M. Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation. Fitoterapia 72 (2001) 894-905
41. Wang Y.P., Li X.Y., Song C.Q., and Hu Z.B. Effect of astragaloside IV on T, B lymphocyte proliferation and peritoneal macrophage function in mice. Acta Pharmacological Sinica 23 (2002) 263-266
42. Widyarini S., Spinks N., Husband A.J., and Reeve V.E. Isoflavonoid compounds from red clover (Trifolium pratense) protect from inflammation and immune suppression induced by UV radiation. Phytochemistry and Photobiology 74 (2001) 465-470
43. Yesilada E., Bedirb E.I., Cali{dotless}s I., Takaishic Y., and Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. Journal of Ethnopharmacology 96 (2005) 71-77
44. Yousef G.E., Mann G.F., Smith D.G., Bell E.J., and McCartney R.A. Chronic enterovirus infection in patients with postviral fatigue syndrome. Lancet 1 (1988) 146-147
45. Yu D.H., Bao Y.M., Wei C.L., and An L.J. Studies of chemical constituents and their antioxidant activities from Astragalus mongholicus Bunge. Biomedical and Environmental Sciences 18 (2005) 297-301
46. Zee-Cheng R.K. Shi-quan-da-bu-tang (ten significant tonic decoction), SQT. A potent Chinese biological response modifier in cancer immunotherapy, potentiation and detoxification of anticancer drugs. Methods and Findings in Experimental and Clinical Pharmacology 14 (1992) 725-736