The transgenic mouse assay as an alternative test method for regulatory carcinogenicity studies-Implications for REACH

Regulatory Toxicology and Pharmacology

Volumn 53, Issue 2, 2009, Pages 150-155

  Wells, Monique Y ^a,b   Williams, E Spencer ^c  

^a Toxicology/Pathology Services Inc   (France)

^b Toxicology/Pathology Services Inc   (United States)

^c ChemRisk   (United States)

Author keywords

Alternative models; Carcinogenicity; Genotoxicity; HESI; High production volume chemicals; ICH; NTP; REACH; Transgenic mice; Two year rodent bioassay

Indexed keywords

ACCURACY; ANIMAL TESTING REDUCTION; ARTICLE; CARCINOGEN TESTING; ENVIRONMENTAL PROTECTION; EUROPEAN UNION; FALSE NEGATIVE RESULT; GENOTOXICITY; HAZARD ASSESSMENT; NONHUMAN; PRIORITY JOURNAL; REGISTRATION; RISK ASSESSMENT; SAFETY; TRANSGENIC MOUSE; TRANSGENIC MOUSE ASSAY;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; DISEASE MODELS, ANIMAL; EUROPEAN UNION; FALSE NEGATIVE REACTIONS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PREDICTIVE VALUE OF TESTS; RISK ASSESSMENT;

ANIMALIA; MUS MUSCULUS; RATTUS; RODENTIA;

EID: 59849125249     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2008.12.006     Document Type: Article

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