Update on National Toxicology Program (NTP) assays with genetically altered or 'transgenic' mice

Environmental Health Perspectives

Volumn 106, Issue 10, 1998, Pages 619-621

  Bucher, John R ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Alternative cancer assays; Genetically altered mice; NTP Board of Scientific Counselors Review; Transgenic mice

Indexed keywords

CARCINOGEN;

ARTICLE; ASSAY; CANCER; ENVIRONMENTAL HEALTH; HEALTH PROGRAM; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESEARCH; TOXICOLOGY; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 0032434620     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106619     Document Type: Article

References (6)

1. Yamamoto S, Hayashi Y, Mitsumori K, Nomura T. Rapid carcinogenicity testing system with transgenic mice harboring human prototype c-HRAS gene. Lab Anim Sci 47:121-126 (1997).
2. Fisher BE. NTP talks transgenics. Environ Health Perspect 106:A177 (1998).
3. Special issue. Toxicol Pathol 26(4): (1998).
4. Sanders JM, Burka LT, Fossett JE, Matthews HB. Comparative xenobiotic metabolism between TG.AC and p53-deficient mice and their respective wild types. Toxicol Sci 42:332 (1998).
5. Tennant RW, French JE, Spalding JW. Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models. Environ Health Perspect 103:942-950 (1995).
6. Harvey M, McArthur MJ, Montgomery CA, Bradley A, Donehower LA. Genetic background alters the spectrum of tumors that develop in p53-deficient mice. FASEB J 7:938-943 (1993).