-
1
-
-
30344456981
-
-
Gao, P., Morozowich, W. Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs. Expert. Opin. Drug Deliv., 3(1), 97-110 (2006).
-
Gao, P., Morozowich, W. Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs. Expert. Opin. Drug Deliv., 3(1), 97-110 (2006).
-
-
-
-
2
-
-
55649125494
-
Selection of clinical SEDDS formulations based on interpretation of preformulation drug properties and preclinical pharmacokinetic performance
-
ed. D.J.Hauss, Marcell Dekker, publication date
-
Gao, P., Morozowich, W. Selection of clinical SEDDS formulations based on interpretation of preformulation drug properties and preclinical pharmacokinetic performance, in "Lipid based formulations for oral drug delivery: Enhancing the bioavailability of poorly water-soluble drugs", ed. D.J.Hauss, (Marcell Dekker), publication date, 2005a.
-
(2005)
Lipid based formulations for oral drug delivery: Enhancing the bioavailability of poorly water-soluble drugs
-
-
Gao, P.1
Morozowich, W.2
-
3
-
-
55749098744
-
-
Gao, P., W.Morozowich, W. Design and development of a new class of supersaturatable SEDDS with potential for enhanced oral absorption and reduced GI side effects, in Lipid based formulations for oral drug delivery: Enhancing the bioavailability of poorly water-soluble drugs, ed. D.J.Hauss, (Marcell Dekker), publication date, 2005b.
-
Gao, P., W.Morozowich, W. Design and development of a new class of supersaturatable SEDDS with potential for enhanced oral absorption and reduced GI side effects, in Lipid based formulations for oral drug delivery: Enhancing the bioavailability of poorly water-soluble drugs, ed. D.J.Hauss, (Marcell Dekker), publication date, 2005b.
-
-
-
-
4
-
-
0344012523
-
-
Gao, P., Rush, B,D, Pfund, W.P., Huang, T., Bauer, J.M., Morozowich, W., Kuo, M.S., Hageman, M,J. Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability. J. Pharm. Sci., 92(12), 2386-98 (2003).
-
Gao, P., Rush, B,D,, Pfund, W.P., Huang, T., Bauer, J.M., Morozowich, W., Kuo, M.S., Hageman, M,J. Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability. J. Pharm. Sci., 92(12), 2386-98 (2003).
-
-
-
-
5
-
-
0021996782
-
-
Serajuddin, A.T.M., Jarowski, C.I. Effect of Diffusion Layer pH and Solubility on the Dissolution Rate of Pharmaceutical Bases and Their Hydrochloride Salts I. Phenylazopyridine. J. Pharm. Sci., 74(2), 142-7 (1985).
-
Serajuddin, A.T.M., Jarowski, C.I. Effect of Diffusion Layer pH and Solubility on the Dissolution Rate of Pharmaceutical Bases and Their Hydrochloride Salts I. Phenylazopyridine. J. Pharm. Sci., 74(2), 142-7 (1985).
-
-
-
-
6
-
-
0035040782
-
Pharmacokinetics of Celecoxib after Oral Administration in Dogs and Humans: Effect of Food and Site of Absorption
-
Paulson, S.K., Vaughn, M.B., Jessen, S.M., Lawal, Y., Gresk, C.J., Yan, B., Maziasz, T.J., Cook, C.C., Karim, A. Pharmacokinetics of Celecoxib after Oral Administration in Dogs and Humans: Effect of Food and Site of Absorption. J.Pharmacol.Exp.Therap., 297(2), 638-645 (2001).
-
(2001)
J.Pharmacol.Exp.Therap
, vol.297
, Issue.2
, pp. 638-645
-
-
Paulson, S.K.1
Vaughn, M.B.2
Jessen, S.M.3
Lawal, Y.4
Gresk, C.J.5
Yan, B.6
Maziasz, T.J.7
Cook, C.C.8
Karim, A.9
-
7
-
-
0002698633
-
Advancing quantitative and mechanistic approaches in interfacing gastrointestinal drug absorption studies in animals and man
-
Crouthamel, W.G. and Sarapu ,A. eds, AphA/APS, Washington, DC, pp
-
Ho, N.H., Park, J.Y., Ni, P.F., Higuchi, W.I. Advancing quantitative and mechanistic approaches in interfacing gastrointestinal drug absorption studies in animals and man, in Animal Models for Oral Drug Delivery in Man, in In Situ and In Vivo Approaches (Crouthamel, W.G. and Sarapu ,A. eds.), AphA/APS, Washington, DC, pp 27-106 (1983).
-
(1983)
Animal Models for Oral Drug Delivery in Man, in In Situ and In Vivo Approaches
, pp. 27-106
-
-
Ho, N.H.1
Park, J.Y.2
Ni, P.F.3
Higuchi, W.I.4
-
9
-
-
0032190504
-
Shapes of membrane permeability-lipophilicity curves: Extension of theoretical models with an aqueous pore pathway
-
Camenisch, G., Folkers, G., van de Waterbeemd, H. Shapes of membrane permeability-lipophilicity curves: extension of theoretical models with an aqueous pore pathway. Eur J Pharm Sci. 6(4), 325-29 (1998).
-
(1998)
Eur J Pharm Sci
, vol.6
, Issue.4
, pp. 325-329
-
-
Camenisch, G.1
Folkers, G.2
van de Waterbeemd, H.3
-
10
-
-
0142139248
-
Designing for topical delivery: Prodrugs can make the difference
-
Sloan, K.B., Wasdo, S. Designing for topical delivery: prodrugs can make the difference. Med. Res. Rev., 23, 763-793 (2003).
-
(2003)
Med. Res. Rev
, vol.23
, pp. 763-793
-
-
Sloan, K.B.1
Wasdo, S.2
-
13
-
-
0035352673
-
Structure-metabolism relationships: Steric effects and the enzymatic hydrolysis of carboxylic esters
-
Buchwald P. Structure-metabolism relationships: steric effects and the enzymatic hydrolysis of carboxylic esters. Mini Rev. Med. Chem., 1(1), 101-11 (2001).
-
(2001)
Mini Rev. Med. Chem
, vol.1
, Issue.1
, pp. 101-111
-
-
Buchwald, P.1
-
14
-
-
0033576649
-
-
Buchwald P, Bodor N. Quantitative structure-metabolism relationships: steric and nonsteric effects in the enzymatic hydrolysis of noncongener carboxylic esters. J.Med.Chem., 16, 42(25), 5160-8 (1999).
-
Buchwald P, Bodor N. Quantitative structure-metabolism relationships: steric and nonsteric effects in the enzymatic hydrolysis of noncongener carboxylic esters. J.Med.Chem., 16, 42(25), 5160-8 (1999).
-
-
-
-
15
-
-
0021956174
-
Strategies in the design of solution-stable, water-soluble prodrugs III: Influence of the pro-moiety on the bioconversion of 21-esters of corticosteroids
-
Anderson, B.D., Conradi, R.A., Spilman, C.H., Forbes, A.D. Strategies in the design of solution-stable, water-soluble prodrugs III: influence of the pro-moiety on the bioconversion of 21-esters of corticosteroids. J. Pharm. Sci., 74(4), 382-7 (1985).
-
(1985)
J. Pharm. Sci
, vol.74
, Issue.4
, pp. 382-387
-
-
Anderson, B.D.1
Conradi, R.A.2
Spilman, C.H.3
Forbes, A.D.4
-
16
-
-
0034603350
-
Influenza virus neuraminidase inhibitors
-
Gubareva, L.V., Kaiser, L., Hayden, F.G. Influenza virus neuraminidase inhibitors. The Lancet, 355, 827-835 (2000).
-
(2000)
The Lancet
, vol.355
, pp. 827-835
-
-
Gubareva, L.V.1
Kaiser, L.2
Hayden, F.G.3
-
17
-
-
0037372498
-
Absorption, Distribution, Metabolism, and Excretion of Ximelagatran, an Oral Direct Thrombin Inhibitor, in Rats, Dogs, and Humans
-
Eriksson, U.G., Bredberg, U., Hoffmann, K.J., Thuresson, A., Gabrielsson, M., Ericsson, H. Absorption, Distribution, Metabolism, and Excretion of Ximelagatran, an Oral Direct Thrombin Inhibitor, in Rats, Dogs, and Humans. Drug Metab Dispos., 31(3), 294-305 (2003).
-
(2003)
Drug Metab Dispos
, vol.31
, Issue.3
, pp. 294-305
-
-
Eriksson, U.G.1
Bredberg, U.2
Hoffmann, K.J.3
Thuresson, A.4
Gabrielsson, M.5
Ericsson, H.6
-
18
-
-
24144447256
-
Pharmacokinetics and pharmacodynamics of ximelagatran
-
Wolzt, M., Sarich, T.S., Eriksson, U.G. Pharmacokinetics and pharmacodynamics of ximelagatran. Semin. Vascul. Med., 5(3), 245- 253 (2005).
-
(2005)
Semin. Vascul. Med
, vol.5
, Issue.3
, pp. 245-253
-
-
Wolzt, M.1
Sarich, T.S.2
Eriksson, U.G.3
-
19
-
-
4644251930
-
XP13512 [(±)-1-([(-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: II. Improved Oral Bioavailability, Dose Proportionality, and Colonic Absorption Compared with Gabapentin in Rats and Monkeys
-
Cundy, K.C., Annamalai, T., Bu, L., De Vera, J., Estrela, J., Luo, W., Shirsat, P., Torneros, P., Yao, F., Zou, J., Barrett, R.W., Gallop, M.A. XP13512 [(±)-1-([(-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: II. Improved Oral Bioavailability, Dose Proportionality, and Colonic Absorption Compared with Gabapentin in Rats and Monkeys. J. Pharmacol. Exp.Therap., 311, 324-333 (2004).
-
(2004)
J. Pharmacol. Exp.Therap
, vol.311
, pp. 324-333
-
-
Cundy, K.C.1
Annamalai, T.2
Bu, L.3
De Vera, J.4
Estrela, J.5
Luo, W.6
Shirsat, P.7
Torneros, P.8
Yao, F.9
Zou, J.10
Barrett, R.W.11
Gallop, M.A.12
-
20
-
-
0036669793
-
Ocular and systemic pharmacokinetics of latanoprost in humans
-
Sjoquist, B., Stjernschantz, J. Ocular and systemic pharmacokinetics of latanoprost in humans. Surv. Ophthalmol., 47(Suppl 1), S6- S12 (2002).
-
(2002)
Surv. Ophthalmol
, vol.47
, Issue.SUPPL. 1
-
-
Sjoquist, B.1
Stjernschantz, J.2
-
21
-
-
0003980770
-
Pharmacokinetics and Metabolism in Drug Design
-
Wiley-VCH, Weinheim, p
-
Smith, D.A., van Waterbeemd, H., Walter, D.K. Pharmacokinetics and Metabolism in Drug Design. In, Methods and Principles in Medicinal Chemistry. Vol. 13, Wiley-VCH, Weinheim, p. 150-195 (2001).
-
(2001)
Methods and Principles in Medicinal Chemistry
, vol.13
, pp. 150-195
-
-
Smith, D.A.1
van Waterbeemd, H.2
Walter, D.K.3
-
22
-
-
1842589355
-
Enhanced oral bioavailability of a poorly water soluble drug PNU-91325 by novel supersaturatable formulations
-
Gao, P., Guyton, M.E., Huang, T., Bauer, J.M., Stefanski, K.J., Lu, Q. Enhanced oral bioavailability of a poorly water soluble drug PNU-91325 by novel supersaturatable formulations. Drug Dev. Ind. Pharm., 30(2), 221-229 (2004).
-
(2004)
Drug Dev. Ind. Pharm
, vol.30
, Issue.2
, pp. 221-229
-
-
Gao, P.1
Guyton, M.E.2
Huang, T.3
Bauer, J.M.4
Stefanski, K.J.5
Lu, Q.6
-
23
-
-
0037403707
-
-
Clement, B., Lopian, K. Characterization of In Vitro Biotransformation of New, Orally Active, Direct Thrombin Inhibitor Ximelagatran, an Amidoxime and Ester Prodrug. 31(5), 645-651 (2003).
-
(2003)
Characterization of In Vitro Biotransformation of New, Orally Active, Direct Thrombin Inhibitor Ximelagatran, an Amidoxime and Ester Prodrug
, vol.31
, Issue.5
, pp. 645-651
-
-
Clement, B.1
Lopian, K.2
-
24
-
-
55749102837
-
-
Plaisance, K, Drusano, G.L, Forest, A, Towsend, R.J. Pharmacokinetic Evaluation of Two Dosage Regimens of Clindamycin
-
Plaisance, K., Drusano, G.L., Forest, A., Towsend, R.J. Pharmacokinetic Evaluation of Two Dosage Regimens of Clindamycin
-
-
-
|