The diagnosis of partial growth hormone deficiency in adults with a putative insult to the hypothalamo-pituitary axis

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 5, 2007, Pages 1705-1709

  Murray, Robert D ^a,b   Bidlingmaier, Martin ^c   Strasburger, Christian J ^d   Shalet, Stephen M ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BIOCHEMICAL MARKER; GENE PRODUCT; GROWTH HORMONE RELEASING FACTOR; IGF BINDING PROTEIN 3; SOMATOMEDIN C; UNCLASSIFIED DRUG; CARRIER PROTEIN; DIAGNOSTIC AGENT; GLYCOPROTEIN; GROWTH HORMONE; HUMAN GROWTH HORMONE; INSULIN; INSULIN LIKE GROWTH FACTOR BINDING PROTEIN, ACID LABILE SUBUNIT; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN, ACID LABILE SUBUNIT; SOMATOMEDIN BINDING PROTEIN 3;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INSULIN TOLERANCE TEST; MALE; MEASUREMENT; PRIORITY JOURNAL; PROVOCATION TEST; BLOOD; BODY MASS; COHORT ANALYSIS; GLUCOSE TOLERANCE TEST; HYPOPHYSIS DISEASE; HYPOTHALAMUS DISEASE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIOTHERAPY; STIMULATION;

ADULT; BODY MASS INDEX; CARRIER PROTEINS; COHORT STUDIES; FEMALE; GLUCOSE TOLERANCE TEST; GLYCOPROTEINS; GROWTH HORMONE; HUMAN GROWTH HORMONE; HUMANS; HYPOTHALAMIC DISEASES; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INSULIN; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; PITUITARY DISEASES; RADIOTHERAPY; STIMULATION, CHEMICAL;

EID: 34249847989     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-2055     Document Type: Article

References (26)

1. Hoffman DM, O'Sullivan AJ, Baxter RC, Ho KK 1994 Diagnosis of growthhormone deficiency in adults. Lancet 343:1064-1068
2. Rahim A, Toogood AA, Shalet SM 1996 The assessment of growth hormone status in normal young adult males using a variety of provocative agents. Clin Endocrinol (Oxf) 45:557-562
3. Darendeliler F, Hindmarsh PC, Brook CG 1990 Dose-response curves for treatment with biosynthetic human growth hormone. J Endocrinol 125:311-316
4. Hoeck HC, Jakobsen PE, Vestergaard P, Falhof J, Laurberg P 1999 Differences in reproducibility and peak growth hormone responses to repeated testing with various stimulators in healthy adults. Growth Horm IGF Res 9:18-24
5. Hoeck HC, Vestergaard P, Jakobsen PE, Laurberg P 1995 Test of growth hormone secretion in adults: poor reproducibility of the insulin tolerance test. Eur J Endocrinol 133:305-312
6. Cianfarani S, Boemi S, Spagnoli A, Cappa M, Argiro G, Vaccaro F, Manca Bitti ML, Boscherini B 1995 Is IGF binding protein-3 assessment helpful for the diagnosis of GH deficiency? Clin Endocrinol (Oxf) 43:43-47
7. Shalet SM, Toogood A, Rahim A, Brennan BM 1998 The diagnosis of growth hormone deficiency in children and adults. Endocr Rev 19:203-223
8. Ghigo E, Aimaretti G, Gianotti L, Bellone J, Arvat E, Camanni F 1996 New approach to the diagnosis of growth hormone deficiency in adults. Eur J Endocrinol 134:352-356
9. Mukherjee A, Monson JP, Jonsson PJ, Trainer PJ, Shalet SM 2003 Seeking the optimal target range for insulin-like growth factor I during the treatment of adult growth hormone disorders. J Clin Endocrinol Metab 88:5865-5870
10. Growth Hormone Research Society 1998 Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. J Clin Endocrinol Metab 83:379-381
11. Murray RD, Shalet SM 2005 Insulin sensitivity is impaired in adults with varying degrees of GH deficiency. Clin Endocrinol (Oxf) 62:182-188
12. Murray RD, Adams JE, Shalet SM 2004 Adults with partial growth hormone deficiency have an adverse body composition. J Clin Endocrinol Metab 89: 1586-1591
13. Colao A, Cerbone G, Pivonello R, Aimaretti G, Loche S, Di Somma C, Faggiano A, Corneli G, Ghigo E, Lombardi G 1999 The growth hormone (GH) response to the arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency. J Clin Endocrinol Metab 84:1277-1282
14. Colao A, Di Somma C, Spiezia S, Rota F, Pivonello R, Savastano S, Lombardi G 2006 The natural history of partial growth hormone deficiency in adults: a prospective study on the cardiovascular risk and atherosclerosis. J Clin Endocrinol Metab 91:2191-2200
15. Toogood AA, Beardwell CG, Shalet SM 1994 The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism. Clin Endocrinol (Oxf) 41:511-516
16. Darzy KH, Aimaretti G, Wieringa G, Gattamaneni HR, Ghigo E, Shalet SM 2003 The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval. J Clin Endocrinol Metab 88:95-102
17. Aimaretti G, Corneli G, Razzore P, Bellone S, Baffoni C, Arvat E, Camanni F, Ghigo E 1998 Comparison between insulin-induced hypoglycemia and growth hormone (GH)-releasing hormone +- arginine as provocative tests for the diagnosis of GH deficiency in adults. J Clin Endocrinol Metab 83:1615-1618
18. Brabant G, von zur Muhlen A, Wuster C, Ranke MB, Kratzsch J, Kiess W, Ketelslegers JM, Wilhelmsen L, Hulthen L, Saller B, Mattsson A, Wilde J, Schemer R, Kann P 2003 Serum insulin-like growth factor I reference values for an automated chemiluminescence immunoassay system: results from a multicenter study. Horm Res 60:53-60
19. Stadler S, Wu Z, Dressendorfer RA, Morrison KM, Khare A, Lee PD, Strasburger CJ 2001 Monoclonal anti-acid-labile subunit oligopeptide antibodies and their use in a two-site immunoassay for ALS measurement in humans. J Immunol Methods 252:73-82
20. Murray RD 2005 The phenotype of adults with partial growth hormone deficiency. Horm Res 64(Suppl 2):12-17
21. Colao A, Di Somma C, Pivonello R, Loche S, Aimaretti G, Cerbone G, Faggiano A, Corneli G, Ghigo E, Lombardi G 1999 Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism. J Clin Endocrinol Metab 84:1919-1924
22. Murray RD, Adams JE, Shalet SM 2006 A densitometric and morphometric analysis of the skeleton in adults with varying degrees of growth hormone deficiency. J Clin Endocrinol Metab 91:432-438
23. Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G 2004 The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: an observational, case-control study. J Clin Endocrinol Metab 89:5998-6004
24. Kopelman PG, Noonan K, Goulton R, Forrest AJ 1985 Impaired growth hormone response to growth hormone releasing factor and insulin-hypoglycaemia in obesity. Clin Endocrinol (Oxf) 23:87-94
25. Williams T, Berelowitz M, Joffe SN, Thorner MO, Rivier J, Vale W, Frohman LA 1984 Impaired growth hormone responses to growth hormone-releasing factor in obesity. A pituitary defect reversed with weight reduction. N Engl J Med 311:1403-1407
26. Melmed S 2006 Supplemental growth hormone in healthy adults: the endocrinologist's responsibility. Nat Clin Pract Endocrinol Metab 2:119