Determinants of sex hormone-binding globulin concentrations in a cross-sectional study of healthy men randomly selected

Journal of Nutrition, Health and Aging

Volumn 11, Issue 1, 2007, Pages 60-64

  Gomez, J M ^b   Maravall, F J ^b   Gomez, N ^b   Navarro, M A ^a   Soler, J ^b  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b NONE

Author keywords

Anthropometry; Body composition; Free IGF I; IGF I; IGFBP3; Leptin; Sex hormone binding globulin

Indexed keywords

LEPTIN; SEX HORMONE BINDING GLOBULIN; SOMATOMEDIN C; TESTOSTERONE;

ADOLESCENT; ADULT; AGED; ANTHROPOMETRY; ARTICLE; BODY COMPOSITION; CONTROLLED STUDY; HORMONE BINDING; HORMONE BLOOD LEVEL; HUMAN; LIPID METABOLISM; MALE; NORMAL HUMAN; PREDICTION; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RISK ASSESSMENT; WAIST HIP RATIO;

ADOLESCENT; ADULT; AGED; AGING; BODY COMPOSITION; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; MALE; MIDDLE AGED; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE; WAIST-HIP RATIO;

EID: 33947192023     PISSN: 12797707     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Goodman-Gruen D, Barrett-Connor E. Sex hormone-binding globulin and glucose tolerance in postmenopausal women. Diabetes Care. 1997; 20: 645-649.
2. Weaver JU, Holly JMP, Kopelman PG, Noonan K, Giadom CG, White N,, Virdee S, Wass JAH Decreased sex hormone binding globulin (SHBG) and insulin-like growth factor binding protein (IGFBP-I) in extreme obesity. Clin. Endocrinol. (Oxf). 1990; 33: 415-422.
3. Birkeland KI, Hanssen KF, Tprjesen PA, Vaaler S. Levels of sex hormone-binding globulin is positively correlated with insulin sensitivity in men with type 2 diabetes (NIDDM). J. Clin. Endocrinol. Metab. 1993; 76: 275-278.
4. Haffner SM, Shaten J, Stern MP, Smith GD, Kuller L, for the MRFI Research Group Low levels of sex hormone-binding globulin and testosterone predict the development on non-insulin-dependent diabetes mellitus in men. Amer. J. Epidemiol. 1996; 143: 889-897.
5. Goodman-Gruen D, Barrett-Connor E. Sex differences in the association of exogenous sex hormone levels and glucose tolerance status in older men and women. Diabetes Care. 2000; 23: 912-918.
6. Oh J-Y, Barret-Connor E, Wedick NM, Wingard DL. Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo study. Diabetes Care. 2002; 25: 55-60.
7. Mingrone G, Greco AV, Giancaterine A, Scarfone A, Castagneto M, Pugeat M. Sex hormone-binding globulin levels and cardiovascular risk factors in morbidly obese subjects before and after weight reduction induced by diet or malabsorptive surgery. Atherosclerosis. 2002; 161: 455-462.
8. Isidori AM, Strollo F, Morè M, Caprio M, Aversa A, Moretti C, Frajese G, Riondino G , Fabbri A Leptin and ageing: correlation with endocrine changes in male and female healthy adult populations of different body weights. J Clin. Endocrinol. Metab. 2000; 85: 1954-1962.
9. Frytsk J, Vetbo E, Skjaebaek C, Mogensen CE, Orskov H. Free insulin-like growth factors in human obesity. Metabolism. 1995; 44: 37-44.
10. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse ob gene and its human homologue. Nature. 1994; 372: 425-432.
11. Considine R, Sinha MK, Heiman M, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, Mckee LJ, Bauer TL , Caro JF Serum immunoreactive leptin concentrations in normal weight and obese humans. N. Engl. J. Med. 1996; 334: 292-295.
12. Yamauchi M, Sugimoto T, Yamaguchi T, Nakaoka D, Kanzawa M, Yano S, Ozuru R, Sugishita T, Chihara K. Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women. Clin. Endocrinol. (Oxf). 2001; 55: 341-347.
13. Haffner SM, Miettinen H,. Karhapaa P, Mykkanen L, Laakso M. Leptin concentrations, sex hormones and cortisol in nondiabetic men, J. Clin. Endocrinol. Metab. 1997; 82: 1807-1809.
14. Garaulet M, Pérez-Llamas F, Fuente T, Zámora S, Tébar FJ. Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor-alpha, sex hormone-binding globulin and sex hormones. Eur. J. Endocrinol. 2000; 143: 657-666.
15. Gómez JM, Molina A, Fernández-Castañer M, Casamitjana R, Martínez-Matos JA, Soler J. Insulin regulation of leptin synthesis and secretion in humans: the model of myotonic dystrophy. Clin. Endocrinol. (Oxf). 1999; 50, 569-575.
16. Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg P, Elia M, Gómez JM, Heitmann BL, Kent-Smith L, Melchior J-C, Pirlich M, Scharfetter H, Schols AMWJ, Pichard C. Bioelectrical impedance analysis - Part II:Utilization in Clinical Practice. Clin Nutr 2004; 23: 1430-1453.
17. DeGroot MH. Probability and statistics (3rd edition). New York: Addison Wesley, 2001.
18. Lehmann EL. Nonparametric statistical methods based on ranks. New York: McGraw-Hill, 1975.
19. Rossner B. Fundamentals of Bioestatistics. 4th edition. New York: Duxbury Press 1995.
20. Plymate SR, Matej LA, Jones RE, Friedl KE. Inhibition of sex hormone binding globulin production in the human hepatoma (HepG2) cell line by insulin and prolactin. J. Clin. Endocrinol. Metab. 1988; 67: 640-647.
21. Belgorosky A, Martínez A, Domene H, Heinrich JJ, Bergadá C, Rivarola MA. High serum sex hormone-binding globulin (SHBG) and non- SHBG-bound testosterone in boys with idiopathic hypopituitarism: effect of recombinant human growth hormone treatment, J. Clin. Endocrinol. Metab. 1987; 65: 1107-1111.
22. Orozco P, Navarro MA, Nolla JM. Salivary testosterone is associated with higher lumbar bone mass in premopausal healthy women with normal levels of serum testosterone. Eur. J. Epidemiol. 2001; 16: 907-912.
23. Lapidus L, Lindstedt G, Lundberg P-A, Bengtsson C, Gerdmark T. Concentrations of sex-hormone-binding globulin and corticosteroid binding globulin in relation to cardiovascular risk factors and to 12-year incidence of cardiovascular disease and overall mortality in postmenopausal women. Clin Chem. 1986; 146: 146-152.
24. Lindstedt G, Lundberg P-A, Lapidus L, Lundgren H, Bengtsson C, Bjorntorp P. Low sex-hormone-binding globulin concentration as independent risk factor for development of NIDDM. Diabetes. 1991; 40: 123-128.
25. Navarro MA, Alía P, Ruiz R, Vallès A, Orozco P. Relación de las concentraciones de globulina transportadora de las hormonas sexuales en suero y de testosterona en suero y saliva con la morfología corporal en mujeres premenopáusicas. Med. Clin. (Bar). 1996; 106: 405-408.
26. Plymate SR, Hoop RC, Jones RE & Matej LA. Regulation of sex hormone-binding globulin production by growth factors. Metabolism. 1990; 39: 967-970.
27. Kalme T, Koistinen HH, Loukovaara M,. Koistinen R, Leinonen P. Comparative studies on the regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) and sex hormone-binding globulin (SHBG) production by insulin a insulin-like growth factors in human hepatoma cells, J. Steroid. Biochem. Mol. Biol. 2003; 86: 197-200.
28. Peiris A.N, Stagner JI, Plymate SR, Vogel RL, Heck M, Samols E. Relationship of insulin secretory pulses to sex hormone-binding globulin in normal men. J. Clin. Endocrinol. Metab. 1993; 76: 279-282.
29. Seek T, Englaro P, Blum WF, Scheidt-Nave C, Rascher W, Ziegler R, Pfeilschifter J. Leptin concentrations in serum from a randomly recruited sample of 50- to 80-year-old men and women: positive association with plasma insulin-like growth factors (IGFs) and IGF-binding protein-3 in lean, but not in obese, individuals. Eur. J. Endocrinol. 1998; 138: 70-75.
30. Gyllenborg J, Rasmussen SL, Borch-Johansen K, Heitmann BL, Skakkebaek NE, Juul A. Cardiovascular risk factors in men: the role of gonadal steroids and sex hormone-binding globulin, Metabolism 2001; 50: 882-888.
31. Fernández Real JM, Vayreda M, Casamitjana R, González-Huix F, Ricart W. The fat-free mass compartment influences serum leptin in men. Eur. J. Endocrinol. 2000; 142: 25-29.
32. Rajaram S, Baylink DJ, Hohan S. Insulin-like growth factor-binding proteins in serum and other biological fluids: regulations and functions. Endocrine Rev. 1997; 18, 801-831.
33. Richman C, Baylink DJ, Lang K & Mohan S 1999 Recombinant human insulin-like growth factor-binding protein-5 stimulates bone formation parameters in vitro and in vivo. Endocrinology, 140, 4699-4705.
34. Baxter RC. Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities, Am. J. Physiol. 2000; 278E967-E976.
35. Pfeilschifter L, Scheidt-Nave C, Leidig-Bruckner G, Woitge HW, Blum WF, Wüster C, Haack D, Ziegler R. Relationship between circulating insulin-like growth factor components and sex hormone in a population-based sample of 50- to 80- year-old men and women, J. Clin. Endocrinol. Metab. 1996; 81: 2534-2540.