Development and in vitro evaluation of a mucoadhesive vaginal delivery system for nystatin

Journal of Pharmaceutical Sciences

Volumn 98, Issue 2, 2009, Pages 555-564

  Hombach, Juliane ^a   Palmberger, Thomas F ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Controlled release; Gels; Mucoadhesion; Nystatin; Oscillatory rheology; Polymer synthesis; Polymeric drug delivery system; Polymers; Thiomer; Vaginal

Indexed keywords

CYSTEINE; MERCAPTAMINE; NYSTATIN; POLYACRYLIC ACID; POLYACRYLIC ACID CYSTEINE CONJUGATE; POLYACRYLIC ACID MERCAPTAMINE CONJUGATE; THIOL DERIVATIVE; UNCLASSIFIED DRUG; ACRYLIC ACID RESIN; ANTIINFECTIVE AGENT; CARBOPOL 940; DRUG CARRIER; MUCIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COW; DRUG ADMINISTRATION ROUTE; DRUG ADSORPTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; MUCOADHESION; NONHUMAN; POLYMERIZATION; SUSTAINED DRUG RELEASE; TABLET FORMULATION; VAGINA; ADHESION; ANIMAL; CATTLE; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG FORMULATION; EVALUATION; FEMALE; FLOW KINETICS; GEL; INTRAVAGINAL DRUG ADMINISTRATION; KINETICS; METABOLISM; MUCOSA; OSCILLOMETRY; PARTICLE SIZE; PH; SOLUBILITY; TABLET; TENSILE STRENGTH;

ACRYLIC RESINS; ADHESIVENESS; ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTI-INFECTIVE AGENTS; CATTLE; CHEMISTRY, PHARMACEUTICAL; CYSTEAMINE; CYSTEINE; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; FEMALE; GELS; HYDROGEN-ION CONCENTRATION; KINETICS; MUCINS; MUCOUS MEMBRANE; NYSTATIN; OSCILLOMETRY; PARTICLE SIZE; RHEOLOGY; SOLUBILITY; TABLETS; TENSILE STRENGTH; VAGINA;

EID: 59849086130     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21457     Document Type: Article

References (19)

1. How HY, Leaseburge L, Khoury JC, Siddiqi TA, Spinnato JA, Sibai BM. 2001. A comparison of various routes and dosages of misoprostol for cervical ripening and the induction of labor. Am J Obstet Gynecol 185:911-915.
2. Richardson JL, Illum L. 1992. Penetration enhancement for polypeptides through epithelia. D. routes of delivery case studies. 8. The vaginal route of peptide and protein drug delivery. Adv Drug Deliv Rev 8:341-366.
3. Tavaniotou A, Smitz J, Bourgain C, Devroey P. 2000. Comparison between different routes of progesterone administration as luteal phase support in infertility treatments. Hum Reprod Update 6:139-148.
4. Valenta C. 2005. The use of mucoadhesive polymers in vaginal delivery. Adv Drug Deliv Rev 57:1692-1712.
5. Leitner VM, Walker GF, Bernkop-Schnürch A. 2003. Thiolated polymers: Evidence for the formation of disulphide bonds with mucus glycoproteins. Eur J Pharm Biopharm 56:207-214.
6. Grabovac V, Guggi D, Bernkop-Schnürch A. 2005. Comparison of the mucoadhesive properties of various polymers. Adv Drug Deliv Rev 57:1713-1723.
7. Lanchares JL, Hernandez ML. 2000. Recurrent vaginal candidiasis changes in etiopathogenical patterns. Int J Gynaecol Obstet 71:S29-S35.
8. King CT, Rogers PD, Cleary JD, Chapman SW. 1998. Antifungal therapy during pregnancy. Clin Infect Dis 27:1151-1160.
9. Marschutz MK, Bernkop-Schnürch A. 2002. Thiolated polymers: Self-crosslinking properties of thiolated 450 kDa poly(acrylic acid) and their influence on mucoadhesion. Eur J Pharm Sci 15:387-394.
10. Bernkop-Schnürch A, Schwarz V, Steininger S. 1999. Polymers with thiol groups: A new generation of mucoadhesive polymers? Pharm Res 16:876-881.
11. Kast CE, Bernkop-Schnürch A. 2001. Thiolated polymers-thiomers: Development and in vitro evaluation of chitosan-thioglycolic acid conjugates. Biomaterials 22:2345-2352.
12. Owen DH, Katz DF. 1999. A vaginal fluid simulant. Contraception 59:91-95.
13. Bernkop-Schnürch A, Steininger S. 2000. Synthesis and characterisation of mucoadhesive thiolated polymers. Int J Pharm 194:239-247.
14. Mortazavi SA. 1993. An investigation into the role of water movement and mucus gel dehydration in mucoadhesion. J Control Rel 25:197-203.
15. Duchene D, Ponchel G. 1992. Principle and investigation of the bioadhesion mechanism of solid dosage forms. Biomaterials 13:709-714.
16. Guggi D, Marschutz MK, Bernkop-Schnürch A. 2004. Matrix tablets based on thiolated poly(acrylic acid): pH-dependent variation in disintegration and mucoadhesion. Int J Pharm 274:97-105.
17. Bernkop-Schnürch A, Kast CE, Richter MF. 2001. Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine. J Control Rel 71:277-285.
18. Leitner VM, Marschutz MK, Bernkop-Schnürch A. 2003. Mucoadhesive and cohesive properties of poly(acrylic acid)-cysteine conjugates with regard to their molecular mass. Eur J Pharm Sci 18:89-96.
19. Deshpande AA, Rhodes CT, Danish M. 1992. Intravaginal drug delivery. Drug Dev Ind Pharm 18:1225-1279.